Inclusion Complexes in Drug Delivery and Drug Targeting: Formation, Characterization, and Biological Applications

Sanku, Rajesh Kishore Kumar; Karakus, Ozlem Ozen; Ilies, Monica; Ilies, Marc A.

doi:10.1021/bk-2019-1309.ch009

Cited by 14 publications

(13 citation statements)

References 206 publications

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“…Nanomedicine in injectable form is indispensable to target cancerous cells (Couvreur, 2013;Sanku et al, 2019;Sharma et al, 2019). On the other hand, these metal nanoparticles can simply conjugate with several mediators such as different types of antibodies, peptides, and RNA/DNA to target the various types of cells.…”

Section: Drug Deliverymentioning

confidence: 99%

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

et al. 2020

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Nanoparticles (nanoparticles) have received much attention in biological application because of their unique physicochemical properties. The metal-and metal oxide-supported nanomaterials have shown significant therapeutic effect in medical science. The mechanisms related to the interaction of nanoparticles with animal and plant cells can be used to establish its significant role and to improve their activity in health and medical applications. Various attempts have been made to discuss the antibiotic resistance and antimicrobial activity of metal-supported nanoparticles. Despite all these developments, there is still a need to investigate their performance to overcome modern challenges. In this regard, the present review examines the role of various types of metal-supported nanomaterials in different areas such as antibacterial, antifungal, anticancer, and so on. Based on the significant ongoing research and applications, it is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas.

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Section: Drug Deliverymentioning

confidence: 99%

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

et al. 2020

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“…One of the major challenges in modern-day pharmacology and medicine is the stable formulation and targeted delivery of therapeutics (Ghosh and Nau, 2012; Sreenivasolu, 2012; Sanku et al, 2019). A major effort in pharmaceutical research is being invested with the aim to achieve the highest impact of a particular therapeutic agent or drug on living systems by creating appropriate delivery vehicles that affect, on one hand, delivery at the desired target and that protect, on the other hand, drug molecules from degradation.…”

Section: Introductionmentioning

confidence: 99%

“…CBs are well-known to bind a wide range of guest molecules, including small organic molecules, amino acids, peptides, and proteins (Macartney, 2011; Shchepotina et al, 2011; Barrow et al, 2015; Sanku et al, 2019). The association of guest molecules to CBs is generally driven by ion-dipole interactions, as well as the classical and non-classical hydrophobic effect (Nau et al, 2011; Assaf and Nau, 2015).…”

Section: Introductionmentioning

confidence: 99%

Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology

2019

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The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. This is made possible by their unique recognition properties and very low cytotoxicity. In this review, we summarize the host-guest complexation of biologically important molecules with CBn, and highlight their implementation in medicinal chemistry and chemical biology.

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“…The development of stable drug formulations and the targeted delivery of therapeutics remain major challenges in pharmacology (Rosenblum et al, 2018 ; Pasut, 2019 ; Sanku et al, 2019 ), and many drugs and drug classes are directly relevant to immune modulation. These include biopharmaceuticals (antibodies, cytokines, chemokines, or peptides) that exhibit biological specificity with well-characterized functions.…”

Section: Macrocycles For Drug Solubilization and Deliverymentioning

confidence: 99%

Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery

2021

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The immune system plays a central role in the development and progression of human disease. Modulation of the immune response is therefore a critical therapeutic target that enables us to approach some of the most vexing problems in medicine today such as obesity, cancer, viral infection, and autoimmunity. Methods of manipulating the immune system through therapeutic delivery centralize around two common themes: the local delivery of biomaterials to affect the surrounding tissue or the systemic delivery of soluble material systems, often aided by context-specific cell or tissue targeting strategies. In either case, supramolecular interactions enable control of biomaterial composition, structure, and behavior at the molecular-scale; through rational biomaterial design, the realization of next-generation immunotherapeutics and immunotheranostics is therefore made possible. This brief review highlights methods of harnessing macromolecular interaction for immunotherapeutic applications, with an emphasis on modes of drug delivery.

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Inclusion Complexes in Drug Delivery and Drug Targeting: Formation, Characterization, and Biological Applications

Cited by 14 publications

References 206 publications

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology

Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery

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