Inclusion complexes of (S)-naproxen and native cyclodextrins: Supramolecular structure and stability

Formulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films

“…30 As was reported previously, this shortcoming of naproxen can be dissolved by forming inclusion complexes with different types of CD molecules. [30][31][32][33][34][35][36][37] Even, in a related study by Séon-Lutz et al, hyaluronic acid/PVA nanofibers were incorporated with the inclusion complexes of hydroxypropyl-beta-cyclodextrin (HPβCD) and naproxen for the purpose of wound dressing applications. 38 In another study reported by the Uyar group, poly(ε-caprolactone) (PCL) nanofibers were functionalized with naproxen/βCD inclusion complexes that provided an enhanced release profile for the drug molecule compared to the CD-free system.…”

Inclusion and Non‐Inclusion Complexes between Curcumin and β‐Cyclodextrin with High‐Curcumin Loading and Enhanced Aqueous Solubility Obtained by Mechanochemistry

“…It is possible to classify them as in solution, involving water or organic solvent/water mixtures, in a semisolid state, incorporating a slight volume of solvents, and processes in the solid state with different types of mills, and usually avoiding the use of organic solvents. [17][18][19] Depending on the method and experimental conditions, other types of CD complexes, like non-inclusion ones (non-ICs), may also participate in solubilizing hydrophobic molecules. [20,21] In the case of milling methods, collective host reservoirs may be formed to embed guest molecules after the amorphization of the sample, displaying higher loading capacity, presumably due to an extensive porosity.…”

“…The obtaining methods of ICs are varied and play a crucial role in the structural features and performance of the products. It is possible to classify them as in solution, involving water or organic solvent/water mixtures, in a semisolid state, incorporating a slight volume of solvents, and processes in the solid state with different types of mills, and usually avoiding the use of organic solvents [17–19] …”