Fish meal (FM) is a major source of animal protein in the diet of turkeys but its high cost has been a major challenge to poultry practitioners in developing countries. Growth performance and blood indices of growing turkeys fed diets containing shrimp waste meal (SWM) as substitute for FM were investigated in a 56-day feeding trial using eighty (80) 4-weeks-old male British United Turkeys (BUT). The turkeys were allotted on weight equalisation into four treatments with four replicates of five turkeys each. Four diets were formulated such that FM in the control diet (diet 1) was substituted by SWM at 150, 300 and 450 g/kg (protein for protein) in diets 2, 3, and 4, respectively. The experiment was arranged in a completely randomised design and data collected were analysed using ANOVA. Cost of feed consumed was highest (p < 0.05) for turkeys fed the control diet and lowest for group fed diet 4. Weight gain decreased (p < 0.05) with increasing SWM level in the diet at the grower phase (day 57–84). Turkeys fed the 450 g/kg SWM diets had the lowest (p < 0.05) feed intake. At the grower phase, best feed:gain, cost of feed consumed, feed cost per weight gain and protein efficiency ratio were recorded in turkeys fed control and 150 g/kg SWM diets. Uric acid, creatinine, cholesterol, alanine aminotransferase (ALT), haematocrit, and white blood count differed significantly (p < 0.05) among the treatments at the starter phase. In conclusion, the present study showed that SWM can serve as a potential replacement for FM when substituted at 150 g/kg in the diets of turkeys without any deleterious effect on their performance and haematocrit.