Inclusive inheritance for residual feed intake in pigs and rabbits

David, Ingrid; Aliakbari, Amir; Déru, Vanille; Garreau, Hervé; Gilbert, Hélène

doi:10.1111/jbg.12494

Cited by 1 publication

(1 citation statement)

References 44 publications

(59 reference statements)

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“…The transmissibility model has been developed to account for genetic and non-genetic inheritance in the estimation of the global transmissible potential of individuals [ 20 , 21 ]. Using phenotype and pedigree information, this model makes it possible to determine whether or not there is a significant proportion of inheritance of non-genetic origin in the vertical transmission of traits [ 22 ], but does not consider the impact of the environment on non-genetic inherited factors. In order to be able to evaluate the adaptation to which environmental conditions are transmitted across generations, our aim is to further develop the transmissibility model to include the quantification of transgenerational transmitted environmental effects.…”

Section: Introductionmentioning

confidence: 99%

An improved transmissibility model to detect transgenerational transmitted environmental effects

David,

Ricard

2023

Genet Sel Evol

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Background Evolutionary studies have reported that non-genetic information can be inherited across generations (epigenetic marks, microbiota, cultural inheritance). Non-genetic information is considered to be a key element to explain the adaptation of wild species to environmental constraints because it lies at the root of the transgenerational transmission of environmental effects. The “transmissibility model” was proposed several years ago to better predict the transmissible potential of each animal by taking these diverse sources of inheritance into account in a global transmissible potential. We propose to improve this model to account for the influence of the environment on the global transmissible potential as well. This extension of the transmissibility model is the “transmissibility model with environment” that considers a covariance between transmissibility samplings of animals sharing the same environment. The null hypothesis of “no transmitted environmental effect” can be tested by comparing the two models using a likelihood ratio test (LRT). Results We performed simulations that mimicked an experimental design consisting of two lines of animals with one exposed to a particular environment at a given generation. This enabled us to evaluate the performances of the transmissibility model with environment so as to detect and quantify transgenerational transmitted environmental effects. The power and the realized type I error of the LRT were compared to those of a T-test comparing the phenotype of the two lines, three generations after the environmental exposure for different sets of parameters. The power of the LRT ranged from 45 to 94%, whereas that of the T-test was always lower than 26%. In addition, the realized type I error of the T-test was 15% and that of the LRT was 5%, as expected. Variances, the covariance between transmissibility samplings, and path coefficients of transmission estimated with the transmissibility model with environment were close to their true values for all sets of parameters. Conclusions The transmissibility model with environment is effective in modeling vertical transmission of environmental effects.

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Section: Introductionmentioning

confidence: 99%