IncobotulinumtoxinA Injection for Temporomandibular Joint Disorder

Abstract

We demonstrate utility of IncobotulinumtoxinA in treating patients with TMD with pain despite pain medication usage and other conventional treatments.

Botulinum Toxin Type A for Painful Temporomandibular Disorders: Systematic Review and Meta-Analysis

“…We found 4 ongoing trials 12,23,33,40 that compared BTX-A versus placebo; these may contribute data in a future update of this review. We included 12 studies 1,7,10,16,17,24,26,35,37,39,51,54 in the review; 9 of these contributed data to meta-analyses (Fig 1).…”

“…Ten 1,7,16,17,24,26,37,39,51,53 of the 12 studies were parallel design RCTs and 2 10,34 were crossover trials. The 12 studies included 362 participants in total, mostly women (87.2%), between 26 and 69 years of age.…”

“…Nine 10,16,24,26,34,37,39,51,53 of the 12 RCTs (267 participants) compared BTX-A versus placebo. Eight trials 10,16,24,34,37,39,51,53 (237 participants) assessed temporomandibular pain reduction using a VAS (0−10 scale, higher values indicate more pain), while one trial 26 asked participants to fill out the RDC/TMD Axis II Biobehavioral Questionnaire to evaluate pain intensity. We pooled the results of 4 RCTs 10,16,24,39 in meta-analyses at 3 time points: 1, 3, and 6 months post-treatment.…”

“…Potential risk factors for painful temporomandibular disorders include trauma, dental malocclusion, excessive masticatory system loading, hypermobility, parafunctional habits and anatomical, psychosocial and/or systemic disorders. 4,5,39 The pain usually involves the masticatory muscles, the preauricular and/or temporomandibular joints and can lead to restriction of mandibular movement and temporomandibular joint blockage. Headaches and cervical pain are also common, depending on the degree of involvement of adjacent muscles.…”

“…Headaches and cervical pain are also common, depending on the degree of involvement of adjacent muscles. 14,20,39 There is a direct relation between progressive pain, the risk of increased symptoms, and deterioration of temporomandibular function. Relaxation of the involved muscles is one of the treatment options for this disorder.…”