Incompatibilities of lornoxicam with 4 antiemetic medications in polyolefin bags during simulated intravenous administration

Fang, Baoxia; Shi, Xiaojian; Chen, Fuchao; Wang, Linhai

doi:10.1097/md.0000000000003824

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…The pharmacokinetic parameters that were evaluated were %ABS, molecular weight (MW), logP, hydrogen bond acceptor (HBA), hydrogen bond donor (HBD), polar surface area (PSA), pKa, and Caco-2 permeability. The data were collected from Zhao et al [13] and previous researches [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Preparation Of Experimental Pharmacokinetic Parametersmentioning

confidence: 99%

“…Chemicalize is the most accurate software in predicting HBA, a Absorption data were taken from Reference [13], b molecular weight data were taken from reference [13], c logP data were taken from Reference [13], d hydrogen bond acceptor (HBA) data were taken from reference [13], e hydrogen bond donor (HBD) data were taken from reference [13], f Lipinski's rule of five (RO5) data were taken from Reference [13]. Checkmark () means the compound fulfilled the rule, g polar surface area (PSA) data were taken from reference [13], h pKa data were taken from reference [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33], i Caco2 permeability data were taken from reference [34,35], -No data, ABS: Absorption PSA, and pKa. Furthermore, admetSAR is the most accurate software in predicting Caco2 permeability.…”

Section: Optimization Of Predicted Pharmacokinetic Parametersmentioning

confidence: 99%

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Prediction Analysis of Pharmacokinetic Parameters of Several Oral Systemic Drugs Using Insilico Method

2020

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Objective: This research aims to observe the pharmacokinetic parameters that can be predicted using a software, discover the best software to predictpharmacokinetic properties, and analyze the correlation between pharmacokinetic parameters used as descriptors with absorption percentage(%ABS) from references.Methods: This research was conducted using Molinspiration, QikProp, admetSAR, SwissADME, Chemicalize, and pkCSM software. This researchanalyzed 34 oral systemic drug compounds for absorption rate and six descriptors comprising molecular weight (MW), logP, hydrogen bond acceptor(HBA), hydrogen bond donor (HBD), polar surface area (PSA), and pKa.Results: SwissADME showed the most accurate prediction of MW, logP, and HBD. Chemicalize showed the most accurate prediction of HBA, PSA, andpKa. Further, admetSAR showed the most accurate prediction of Caco-2 permeability. The highest R value was obtained from the correlation between%ABS with Caco-2 permeability on 34 drug compounds (R=0.8211).Conclusion: The highest R value was obtained from the correlation between %ABS with Caco2 permeability on 34 drug compounds (R=0.8211),which showed a significant relationship (*p<0.001). This indicates that oral systemic drugs are affected by Caco-2 permeability. Moreover, the result of this research can be considered for the development of oral systemic drugs.

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Section: Preparation Of Experimental Pharmacokinetic Parametersmentioning

confidence: 99%

Section: Optimization Of Predicted Pharmacokinetic Parametersmentioning

confidence: 99%

Prediction Analysis of Pharmacokinetic Parameters of Several Oral Systemic Drugs Using Insilico Method

2020

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“…Known incompatibilities, such as color change, pH shifts, precipitation, particle formation, gas evolution, and crystallization during i.v. administration arising from the combination of therapies can exist [ 18 ]. Hence, knowledge of the compatibility and stability of this drug combination is important.…”

Section: Introductionmentioning

confidence: 99%

Stability of azasetron-dexamethasone mixture for chemotherapy-induced nausea and vomiting administration

et al. 2017

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Combination antiemetic therapy has become common practice for the prevention of nausea and vomiting caused by anticancer drugs. In this study, we investigated the stability of azasetron hydrochloride 0.1 mg/mL plus dexamethasone sodium phosphate 0.05, 0.1, or 0.2 mg/mL in 0.9% sodium chloride injection and stored in polyolefin bags and glass bottles over a period of 14 days at 4°C and 48 hours at 25°C. The stability studies were evaluated by visual inspection, pH measurement, and a high-pressure liquid chromatography assay of drug concentrations. During the study period, the concentration of each drug in the various solutions remained above 97% of the initial concentration at both 4°C and 25°C when protected from room light. Under the condition of 25°C with exposure to room light, the concentrations of both drugs were significantly lowered over 48 hours. The pH value decreased, and the color changed from colorless to pink. Our study demonstrates that the azasetron-dexamethasone mixture at a clinically relevant concentration seems to be stable for 48 hours at 25°C and for 14 days at 4°C when packaged in polyolefin bags or glass bottles and protected from room light. The room light is the main influential factor on stability. Clinicians should be aware that combinations of azasetron hydrochloride and dexamethasone sodium phosphate in solution with light exposure should be avoided.

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“…Outros métodos por CLAE foram utilizados para monitoramento da estabilidade da ondansetrona em produtos farmacêuticos e em soluções mantidas em equipos médicos, como em solução de dextrose a 5% e cloreto de sódio injetáveis em seringas de polipropileno (CASTO, 1994;BURM, 1997) e em associação com outros IFA (STEWART et al, 1998;BOUGOUIN et al, 2001;WANG et al, 2016;FANG et al, 2016), incluindo a exposição das amostras a condições de estresse por temperatura, hidrólise ácida e alcalina. Em alguns trabalhos verificou-se queda no teor (CASTO, 1994;BURM, 1996;STEWART et al, 1998;FANG et al, 2016), porém a identidade ou concentração de possíveis compostos de degradação formados não foram determinadas.…”

Section: Métodos Disponíveis Na Literaturaunclassified

“…De acordo com os trabalhos mencionados na literatura (CASTO, 1994;BURM, 1997;STEWART et al, 1998;BOUGOUIN et al, 2001;WANG et al, 2016;FANG et al, 2016)…”

Section: Estudos De Estresseunclassified

Desenvolvimento de um método indicativo de estabilidade para ondansetrona

Maranho¹

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Um método analítico baseado na cromatografia líquida de ultraeficiência com detecção por ultravioleta e espectrometria de massas para análise do teor e limite de impurezas e compostos de degradação para o principio ativo farmacêutico ondansetrona e três diferentes formas farmacêuticas foi desenvolvido utilizando conceitos de qualidade analítica por planejamento (aQbD) e validado de acordo com os requerimentos da USP-NF e do ICH. O método desenvolvido apresentou capacidade de separação de vinte compostos detectados nas amostras envolvidas no estudo: o princípio ativo ondansetrona, sete impurezas descritas nos principais compêndios farmacopéicos mundiais (United States Pharmacopeia-National Formulary, European Pharmacopoeia, British Pharmacopoeia e Indian Pharmacopoeia), onze compostos de degradação gerados pelos estudos de estresse e um excipiente. O método final apresentou um tempo de corrida de 14 minutos, com vazão de fase móvel de 0,4 mL/min, detecção de impurezas por ultravioleta a 220 nm e do princípio ativo a 305 nm, com apoio da detecção por espectrometria de massas de alta resolução (QTOF). Em comparação aos métodos requeridos pelas monografias relacionadas à ondansetrona publicadas nos compêndios farmacopéicos citados, o método desenvolvido apresenta uma alternativa eficiente e econômica para a análise de rotina de diferentes formas da matéria-prima ondansetrona (base, cloridrato, diferentes níveis de hidratação) e formas farmacêuticas (comprimidos, comprimidos de desintegração oral e solução injetável), mostrando que a modernização dos métodos cromatográficos, além de garantir a qualidade dos produtos farmacêuticos e promover a saúde da população, tem um impacto relevante na economia da produção e análise de medicamentos e na diminuição do impacto ao meio ambiente. Palavras-chave: ondansetrona; método indicativo de estabilidade; cromatografia líquida de ultraeficiência; espectrometria de massas; planejamento experimental; qualidade analítica por planejamento.

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Incompatibilities of lornoxicam with 4 antiemetic medications in polyolefin bags during simulated intravenous administration

Cited by 8 publications

References 26 publications

Prediction Analysis of Pharmacokinetic Parameters of Several Oral Systemic Drugs Using Insilico Method

Prediction Analysis of Pharmacokinetic Parameters of Several Oral Systemic Drugs Using Insilico Method

Stability of azasetron-dexamethasone mixture for chemotherapy-induced nausea and vomiting administration

Desenvolvimento de um método indicativo de estabilidade para ondansetrona

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