Inconsistent lateralisation of language functions: a risk factor for language impairment?

Bradshaw, Abigail R.; Woodhead, Zoe; Thompson, Paul A.; Bishop, Dorothy V. M.

doi:10.31234/osf.io/54pnh

Cited by 1 publication

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“…We also note that regional lateralization tends to change across tasks in both HC and LTLE. This is in line with previous findings suggesting that hemispheric lateralization for language is not a rigid and a unitary construct ( Bradshaw et al, 2017 , 2019 ) but varies according to regions and specific processes. Similarly, it was shown that different memory processes and types of stimuli could result in different memory lateralization ( Golby et al, 2002 ; Milian et al, 2015 ; Andreau and Torres Batán, 2019 ; Palacio and Cardenas, 2019 ).…”

Section: Discussionsupporting

confidence: 93%

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Banjac

Roger

Cousin

et al. 2022

Front. Hum. Neurosci.

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Preoperative mapping of language and declarative memory functions in temporal lobe epilepsy (TLE) patients is essential since they frequently encounter deterioration of these functions and show variable degrees of cerebral reorganization. Due to growing evidence on language and declarative memory interdependence at a neural and neuropsychological level, we propose the GE2REC protocol for interactive language-and-memory network (LMN) mapping. GE2REC consists of three inter-related tasks, sentence generation with implicit encoding (GE) and two recollection (2REC) memory tasks: recognition and recall. This protocol has previously been validated in healthy participants, and in this study, we showed that it also maps the LMN in the left TLE (N = 18). Compared to healthy controls (N = 19), left TLE (LTLE) showed widespread inter- and intra-hemispheric reorganization of the LMN through reduced activity of regions engaged in the integration and the coordination of this meta-network. We also illustrated how this protocol could be implemented in clinical practice individually by presenting two case studies of LTLE patients who underwent efficient surgery and became seizure-free but showed different cognitive outcomes. This protocol can be advantageous for clinical practice because it (a) is short and easy to perform; (b) allows brain mapping of essential cognitive functions, even at an individual level; (c) engages language-and-memory interaction allowing to evaluate the integrative processes within the LMN; (d) provides a more comprehensive assessment by including both verbal and visual modalities, as well as various language and memory processes. Based on the available postsurgical data, we presented preliminary results obtained with this protocol in LTLE patients that could potentially inform the clinical practice. This implies the necessity to further validate the potential of GE2REC for neurosurgical planning, along with two directions, guiding resection and describing LMN neuroplasticity at an individual level.

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Section: Discussionsupporting

confidence: 93%

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Banjac

Roger

Cousin

et al. 2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

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Inconsistent lateralisation of language functions: a risk factor for language impairment?

Abstract: Journal section: Cognitive Neuroscience Number of pages (incl. references and figures/tables): 48 Number of words in the whole manuscript (incl. references): 8812 Number of words in the abstract: 249 Number of figures: 7 Number of tables: 4

Cited by 1 publication

References 34 publications

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

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