Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma

Abstract

Summary.Three uncommon findings were observed in a case of Cushing's disease due to macroadenoma: no suppression of plasma ACTH during an 8-rag dexamethasone test, a negative corticotropin-releasing factor test, and a normal X-ray of the sella turcica. Despite these findings, the diagnosis of pituitary was confirmed Cushing's syndrome by computerized tomography and a transphenoidal operation.