Incontinentia Pigmenti Achromians (Ito)

Abstract

A patient with incontinentia pigmenti achromians was reported. She displayed other abnormalities such as a saddle nose, malformed auricles, growth retardation, convulsions and abnormal EEG. Histopathologically, a partial decrease in melanin granules in the basal layer and the presence of melanocytes which showed a weak dopa reaction were the main findings. The hypofunction of melanin production was detected by electron microscopy.

Introduction

“…The suggested readings show the number of publications produced in 1975 on the topic of in situ hybridization or immunohistochemistry; note that there were eight such papers [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] . Compare this to the list of publications produced in 1980 on in situ hybridization or immunohistochemistry; note that there were 34 [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] . These references are included to give homage to the pioneers in these two fields.…”