Large‐scale environment fields play an important role in the accurate prediction of typhoons. However, regional predictions for typhoons often suffer from inadequate representation of large‐scale flow pattern such as those from global models due to limited domain size and observations employed in regional models, especially when multiple typhoons that interact concurrently occur in a regional domain. This study merges the large‐scale information from global model forecasts with the mesoscale information from regional model forecasts in the hybrid ensemble‐variational (EnVar) data assimilation by adding an analysis constraint in the EnVar cost function, which is defined by the departure of the regional model EnVar analysis from the global model fields and takes advantage of flow‐dependent ensemble background error covariance for the introduction of large scales using data assimilation. The EnVar assimilation impacts of the large‐scale fields on predictions of triple typhoons are assessed by conducting cycling assimilation and forecast experiments for a 13‐day‐long period in July 2015 when three typhoons concurrently occurred. Results show that the large‐scale constraint for EnVar can clearly improve the triple‐typhoons' track and intensity forecasts of the regional model. The large‐scale information introduced by the proposed method is also shown to reduce forecast errors of wind, temperature and humidity, respectively. Predictions of the rainfall caused by typhoons are also ameliorated. Besides, the analysis‐constrained regional predictions provide better model dynamic fields in terms of sea surface pressure, geopotential height, and water vapor transport, as well as developed typhoon structures. In addition, the adaptive bias correction for radiance assimilation presents a stable performance under the influence of introducing extra background large‐scale fields. The results indicate that the large‐scale analysis constraint introduced in the hybrid EnVar takes advantages of the multiscale information from the global model and the regional model respectively, thus improving the final results of the predictions of multiple typhoons.