Incorporating Cellular Stochasticity in Solid–Fluid Mixture Biofilm Models

Carpio, Ana; Cebrián, Elena

doi:10.3390/e22020188

Cited by 5 publications

(2 citation statements)

References 39 publications

(152 reference statements)

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“…Modeling bacterial growth in the biofilm habitat is a complex task due to the need to couple cellular, mechanical and chemical processes acting on different times scales. Many approaches have been proposed, ranging from purely continuous models [8] to agent based descriptions [4-7, 9, 10] and hybrid models combining both [13,14]. Complexity increases when we aim to take bacterial geometry into account, issue that we intend to address here borrowing ideas from immersed boundary (IB) methods [22].…”

Section: Introductionmentioning

confidence: 99%

Immersed Boundary Approach to Biofilm Spread on Surfaces

Carpio¹,

González-Albaladejo²

2022

CICP

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We propose a computational model to study the growth and spread of bacterial biofilms on interfaces, as well as the action of antibiotics on them. Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject to interaction forces. Growth, division and death of bacterial cells follow dynamic energy budget rules, in response to variations in environmental concentrations of nutrients, toxicants and substances released by the cells. In this way, we create, destroy and enlarge boundaries, either spherical or rod-like. Appropriate forces represent details of the interaction between cells, and the interaction with the environment. We can investigate geometrical arrangements and the formation of porous structures. Numerical simulations illustrate the evolution of top views and diametral slices of small biofilm seeds, as well as the action of antibiotics. We show that cocktails of antibiotics targeting active and dormant cells can entirely eradicate a biofilm.

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Section: Introductionmentioning

confidence: 99%

Immersed Boundary Approach to Biofilm Spread on Surfaces

Carpio¹,

González-Albaladejo²

2022

CICP

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“…Modeling bacterial growth in the biofilm habitat is a complex task due to the need to couple cellular, mechanical and chemical processes acting on different times scales. Many approaches have been proposed, ranging from purely continuous models [9] to agent based descriptions [6-8, 10, 11] and hybrid models combining both [12,13]. Complexity increases when we aim to take bacterial geometry into account, issue that we intend to address here borrowing ideas from immersed boundary (IB) methods [21].…”

Section: Introductionmentioning

confidence: 99%

Immersed boundary approach to biofilm spread on surfaces

Carpio,

Gonzalez-Albaladejo

2022

Preprint

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We propose a computational framework to study the growth and spread of bacterial biofilms on interfaces, as well as the action of antibiotics on them. Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject to interaction forces. Growth, division and death of bacterial cells follow dynamic energy budget rules, in response to variations in environmental concentrations of nutrients, toxicants and substances released by the cells. In this way, we create, destroy and enlarge boundaries, either spherical or rod-like. Appropriate forces represent details of the interaction between cells, and the interaction with the environment. Numerical simulations illustrate the evolution of top views and diametral slices of small biofilm seeds, as well as the action of antibiotics. We show that cocktails of antibiotics targeting active and dormant cells can entirely eradicate a biofilm.

show abstract