Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior

Wan, Yizao; Lin, Zhonghong; Zhang, Quanchao; Gan, Deqiang; Gama, Miguel; Tu, Junpin; Luo, Honglin

doi:10.1007/s10570-020-03078-w

Cited by 15 publications

(9 citation statements)

References 58 publications

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“…2A) reveal the fibrous structure of CA, BNC, CA/ BNC, and CA/BNC-H grafts. CA has thick electrospun fibers and BNC shows nanofibrous and porous morphology, in consistent with previous reports [31,32]. CA/BNC and CA/BNC-H show entangled dual fibers of thick CA fibers and fine BNC fibers.…”

Section: Characterization Of Ca/bnc-h Graftssupporting

confidence: 92%

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Zhang

Zhu

et al. 2021

Materials Science and Engineering: C

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Constructing biomimetic structure and immobilizing antithrombus factors are two effective methods to ensure rapid endothelialization and long-term anticoagulation for small-diameter vascular grafts. However, few literatures are available regarding simultaneous implementation of these two strategies. Herein, a nano-micro-fibrous biomimetic graft with a heparin coating was prepared via a step-by-step in situ biosynthesis method to improve potential endothelialization and anticoagulation. The 4-mm-diameter tubular graft consists of electrospun cellulose acetate (CA) microfibers and entangled bacterial nanocellulose (BNC) nanofibers with heparin coating on dual fibers. The hybridized and heparinized graft possesses suitable pore structure that facilitates endothelia cells adhesion and proliferation but prevents infiltration of fibrous tissue and blood leakage. In addition, it shows higher mechanical properties than those of bare CA and hybridized CA/BNC grafts, which match well with native blood vessels. Moreover, this dually modified graft exhibits improved blood compatibility and endothelialization over the counterparts without hybridization or heparinization according to the testing results of platelet adhesion, cell morphology, and protein expression of von Willebrand Factor. This novel graft with dual modifications shows promising as a new small-diameter vascular graft. This study provides a guidance for promoting endothelialization and blood compatibility by dual modifications of biomimetic structure and immobilized bioactive molecules.

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Section: Characterization Of Ca/bnc-h Graftssupporting

confidence: 92%

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Zhang

Zhu

et al. 2021

Materials Science and Engineering: C

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“…In the case of cancer cells, proliferation was adjusted to enable the formation of 3D spheroids of cancer cells and long-term cell culture. Graphene derivatives regulate the microenvironments of target cells Recently, Wan et al also reported that GO exerts a positive effect on the growth of cancer cells when incorporated with the scaffold structure [119]. In this study, a scaffold consisting of cellulose acetate (CA) microfibers in combination with bacterial cellulose (BC) was fabricated, and GO was further added to the CA-BC scaffold.…”

Section: Discussionmentioning

confidence: 98%

“…Recently, Wan et al also reported that GO exerts a positive effect on the growth of cancer cells when incorporated with the scaffold structure [ 119 ]. In this study, a scaffold consisting of cellulose acetate (CA) microfibers in combination with bacterial cellulose (BC) was fabricated, and GO was further added to the CA-BC scaffold.…”

Section: Controlling 3d Cancer Cell Microenvironments Using Graphementioning

confidence: 99%

Graphene Hybrid Materials for Controlling Cellular Microenvironments

Kim

2020

Materials

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Cellular microenvironments are known as key factors controlling various cell functions, including adhesion, growth, migration, differentiation, and apoptosis. Many materials, including proteins, polymers, and metal hybrid composites, are reportedly effective in regulating cellular microenvironments, mostly via reshaping and manipulating cell morphologies, which ultimately affect cytoskeletal dynamics and related genetic behaviors. Recently, graphene and its derivatives have emerged as promising materials in biomedical research owing to their biocompatible properties as well as unique physicochemical characteristics. In this review, we will highlight and discuss recent studies reporting the regulation of the cellular microenvironment, with particular focus on the use of graphene derivatives or graphene hybrid materials to effectively control stem cell differentiation and cancer cell functions and behaviors. We hope that this review will accelerate research on the use of graphene derivatives to regulate various cellular microenvironments, which will ultimately be useful for both cancer therapy and stem cell-based regenerative medicine.

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“…Natural biopolymers owing to their low toxicity, biodegradability, renewability, environmental sensitivity, and biocompatibility are also promising materials to improve the biological properties of graphene-based materials. [142][143][144][145] Chitosan with anticancer activity and as a pH sensitive polymer has been widely employed in the synthesis of polymergraphene hybrids. [146][147][148] The produced multifunctional scaffolds have exhibited high loading capacities and functional binding sites for different types of drugs and targeting ligands.…”

Section: Graphene-polymer Platforms In Drug Deliverymentioning

confidence: 99%

Functionalized Graphene Platforms for Anticancer Drug Delivery

Sattari¹,

Adeli²,

Beyranvand³

et al. 2021

IJN

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Two-dimensional nanomaterials are emerging as promising candidates for a wide range of biomedical applications including tissue engineering, biosensing, pathogen incapacitation, wound healing, and gene and drug delivery. Graphene, due to its high surface area, photothermal property, high loading capacity, and efficient cellular uptake, is at the forefront of these materials and plays a key role in this multidisciplinary research field. Poor water dispersibility and low functionality of graphene, however, hamper its hybridization into new nanostructures for future nanomedicine. Functionalization of graphene, either by covalent or non-covalent methods, is the most useful strategy to improve its dispersion in water and functionality as well as processability into new materials and devices. In this review, recent advances in functionalization of graphene derivatives by different (macro)molecules for future biomedical applications are reported and explained. In particular, hydrophilic functionalization of graphene and graphene oxide (GO) to improve their water dispersibility and physicochemical properties is discussed. We have focused on the anticancer drug delivery of polyfunctional graphene sheets.

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Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior

Cited by 15 publications

References 58 publications

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Graphene Hybrid Materials for Controlling Cellular Microenvironments

Functionalized Graphene Platforms for Anticancer Drug Delivery

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