Incorporating β-cyclodextrin into collagen scaffolds to sequester growth factors and modulate mesenchymal stem cell activity

Grier, William K.; Tiffany, Aleczandria S.; Ramsey, Matthew D.; Harley, Brendan A.C.

doi:10.1016/j.actbio.2018.06.033

Cited by 34 publications

(26 citation statements)

References 63 publications

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“…When incorporated into a model scaffold made of collagen and glycoseaminoglycan, β-CD was shown to influence the metabolic activity and proliferation of mesenchymal stem cells, driving them towards osteo-chondral differentiation. This happens because β-CD forms inclusion complexes with two growth factors, TGF-β1 and BMP-2, and then releases them in a slow, sustained fashion [119]. A joint filler comprising an association of β-CD or HPβCD with hyaluronate and chondroitin is patented for use in the treatment or prevention of cartilage degeneration and arthrosis or arthritis diseases, or as a filling agent for soft tissues and mucosae [120].…”

Section: Joint Fillers For Arthritismentioning

confidence: 99%

Cyclodextrins: Emerging Medicines of the New Millennium

2019

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Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as excipients. Nevertheless, developments in cyclodextrin research have shown that some of these hosts can capture and include biomolecules, highlighting fatty acids and cholesterol, which implies that they are not inert and that their action may be used in specific medicinal purposes. The present review, centered on literature reports from the year 2000 until the present day, presents a comprehensive description of the known biological activities of cyclodextrins and their implications for medicinal applications. The paper is divided into two main sections, one devoted to the properties and applications of cyclodextrins as active pharmaceutical ingredients in a variety of pathologies, from infectious ailments to cardiovascular dysfunctions and metabolic diseases. The second section is dedicated to the use of cyclodextrins in a range of biomedical technologies.

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Section: Joint Fillers For Arthritismentioning

confidence: 99%

Cyclodextrins: Emerging Medicines of the New Millennium

2019

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“…Collagen–glycoseaminoglycan scaffolds that incorporate β-CD showed improved sequestration as well as the extended retention and release of TGF-β1 (transforming growth factor beta 1) and BMP-2 (bone morphogenetic protein 2), which influence the metabolic activity and proliferation of mesenchymal stem cells. Moreover, a gene expression analysis showed that the TGF-β1 released from β-CD promoted early chondrogenic-specific differentiation [ 135 ]. Finally, for the treatment or prevention of cartilage degeneration and arthrosis or arthritis a patent has been registered for the use of CDs with hyaluronate and chondroitin [ 136 ].…”

Section: Cyclodextrins As Active Drugsmentioning

confidence: 99%

Cyclic Oligosaccharides as Active Drugs, an Updated Review

et al. 2020

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There have been many reviews of the cyclic oligosaccharide cyclodextrin (CD) and CD-based materials used for drug delivery, but the capacity of CDs to complex different agents and their own intrinsic properties suggest they might also be considered for use as active drugs, not only as carriers. The aim of this review is to summarize the direct use of CDs as drugs, without using its complexing potential with other substances. The direct application of another oligosaccharide called cyclic nigerosyl-1,6-nigerose (CNN) is also described. The review is divided into lipid-related diseases, aggregation diseases, antiviral and antiparasitic activities, anti-anesthetic agent, function in diet, removal of organic toxins, CDs and collagen, cell differentiation, and finally, their use in contact lenses in which no drug other than CDs are involved. In the case of CNN, its application as a dietary supplement and immunological modulator is explained. Finally, a critical structure–activity explanation is provided.

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“…In order to develop more and more performant biomaterials for tissue engineering, special attention has to be given to increasing the bioavailability of biomolecular cues (e.g. growth factors) to promote desired cell responses (Grier et al, 2018). The CD tissue engineering applications that are already under development are joint or bone trauma and arthritis (Braga, 2019).…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…-CD is used to bind growth factors (transforming growth factor -TGF-β1 and bone morphogenic proteins -BMP-2) from solution prior to cell-seeding, as a way to stimulate mesenchymal stem cells (MSC) differentiation with lineage guidance. By incorporating these complexes within a collagenglycosaminoglycan scaffold, they can help generate new bone and cartilage, by driving MSCs towards osteo-chondral differentiation and proliferation (Braga, 2019;Grier et al, 2018).…”

Section: Tissue Engineeringmentioning

confidence: 99%

Cyclodextrins – development and applications of these versatile oligosaccharides

2020

Biomater Tissue Eng Bull

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. Cyclodextrins (CDs) are cyclic oligossacharides which have been known and studied for almost 130 years. This review aims to highlight the most important findings registered over this time, the physicochemical properties, preparation methods and uses of cyclodextrins, with special focus on their recently discovered applications. Due to their unique conformation, cyclodextrins are able to encapsulate a wide range of chemical entities, impacting on their solubility, bioavailability, stability, and shelf-life. Their complex formation properties together with the production from natural sources opens the door for cyclodextrins to be used in numerous and varied industries. However, the most important consumer of these versatile sugars is represented by the biomedical domain, where cyclodextrins find uses in drug formulations, delivery systems, medical textiles, implantable devices, tissue engineering, and many other connex applications. Moreover, intense research is still performed for this compounds, to develop and extend their therapeutic potential and serve as promising alternatives for treatment of severe diseases.

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Incorporating β-cyclodextrin into collagen scaffolds to sequester growth factors and modulate mesenchymal stem cell activity

Cited by 34 publications

References 63 publications

Cyclodextrins: Emerging Medicines of the New Millennium

Cyclodextrins: Emerging Medicines of the New Millennium

Cyclic Oligosaccharides as Active Drugs, an Updated Review

Cyclodextrins – development and applications of these versatile oligosaccharides

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