Incorporation and Release Kinetics of Alpha-Bisabolol From PCL and Chitosan/Guar Gum Membranes

Abstract

-Alpha-bisabolol, an anti-inflammatory and antioxidant compound extracted from candeia trees (Eremanthus erythropappus), was incorporated into hydrophobic polycaprolactone (PCL) and hydrophilic chitosan/guar gum (Ch-G) membranes aiming at the production of bioactive wound dressings. The incorporation efficiency achieved a maximum of ca. 18% (1 gram of alpha-bisabolol per gram of membrane) for Ch-G membranes. For PCL membranes, all of the active compound added was retained (0.2 gram of alpha-bisabolol per gram of membrane). Alpha-bisabolol release in phosphate-buffered saline was relatively slow in both cases, reaching around 6% and 24% after 120 hours respectively for PCL and Ch-G membranes presenting equivalent initial alpha-bisabolol/membrane mass ratios. Both formulations were capable of releasing alpha-bisabolol in the typically recommended topical dose range (from 1 to 10 grams of alphabisabolol per gram of vehicle). The extended release periods observed are advantageous, allowing less frequent dressing changes and contributing to turn the treatment more comfortable for the patient.

Analysis of the performance of polysaccharide membranes in aqueous media as a tool to assist wound‐dressing selection

“…When wet, all of the membranes were highly transparent and capable of easily adjusting to the body's contours [ Figure 1 Figure 1(F)], which also showed fibers on its surface. The same behavior was observed by Souza et al 42 Conversely, the Ch-G membranes had a dense structure and a rather smooth surface [ Figure 1(I)], as reported previously by Souza et al 49 Souza et al 42 proposed a mechanism for the organization of Ch-A and Ch-X membranes in lamellar structures on the basis of the interactions that stabilize the final PEC structure. The formation of this structure involves three steps.…”

“…In our previous studies, FTIR analysis of Ch-G membranes 49 was performed, and this confirmed the occurrence of interactions between the two polymers. In addition, for Ch-A and Bellini et al 40 produced Ch-X membranes with xanthan from two different sources, the first commonly used as an additive in food processing and the second produced in a local pilot plant.…”

“…In our previous studies, FTIR analysis of Ch-G membranes 49 was performed, and this confirmed the occurrence of interactions between the two polymers. In addition, for Ch-A and Ch-X membranes, 42 FTIR analysis corroborated the formation of PECs among the polymers through interactions between the amino groups of chitosan and the carboxyl groups of alginate and xanthan gum.…”

<p>α-Bisabolol-Loaded Cross-Linked Zein Nanofibrous 3D-Scaffolds For Accelerating Wound Healing And Tissue Regeneration In Rats</p>

“…The transmittance of the bands between 1658–1531 cm −1 of blank C-ZNFs scaffolds (F9–F12) was significantly reduced compared to pure zein, which confirmed the de-amidation of glutamine and the diminishment of the α-helical structure of zein 48. While BIS showed its typical bands correlated to stretching of –-OH between 3429–3300 cm −1 and characteristic peaks related to axial deformations of the C–H bonds between 3000–2890 cm −1 49. It was noticed that most of the absorption peaks of BIS, which exist in the IR spectra of BIS-loaded C-ZNFs scaffold (F15), offered lower intensities.…”

Effects of Electrospun Fibrous Membranes of PolyCaprolactone and Chitosan/Poly(Ethylene Oxide) on Mouse Acute Skin Lesions

“…The use of chitosan-based wound coverings is a reality in the market-for instance, products such as ChitoFlex ® PRO, ChitoGauze ® PRO XR, and Celox GauzeTM [5]. Chitosan can be obtained from the deacetylation of chitin, which is found in the exoskeleton of crustaceans, insects, and mollusks and in the cell wall of fungi [6,7]. Through deacetylation, it is possible to increase the solubility of the natural polysaccharide and its technological applicability [3].…”