Incorporation of 28-d Leptocheirus plumulosus toxicity data in a sediment weight-of-evidence framework

McDonald, Blair G.; McPherson, Cathy A.; DeWynter, Rachel; Kickham, Peter; Brown, Carrie

doi:10.1016/j.ecoenv.2009.08.007

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Although the variability in the present study was relatively high, good replication, as recommended by Scarlett et al , meant that significant differences in growth and reproduction were detected compared with control. Similar problems of variability exist with alternative protocols for sediment test organisms such as the 28‐d study with the amphipod Leptocheirus plumulosus . Further work on the relationships among feeding behavior of amphipods, the composition of natural sediments, and the bioavailability of chemicals might help us to understand the variability observed in these studies and aid in interpretation of the results.…”

Section: Discussionmentioning

confidence: 93%

The use of a Corophium volutator chronic sediment study to support the risk assessment of medetomidine for marine environments

Fox

Ohlauson

Sharpe

et al. 2014

Enviro Toxic and Chemistry

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Chronic sediment studies were conducted using the marine amphipod Corophium volutator as part of an environmental risk assessment of the novel antifouling compound medetomidine. Two studies were performed, starting with neonates of less than 7 d old. A 28-d study considered endpoints of survival and growth (length and wet wt) and a 76-d study looked at survival, growth (length and wet wt), and reproduction (number of gravid females and neonates). Medetomidine was dosed via the sediment at nominal test concentrations of 1.0 µg/kg, 3.2 µg/kg, 10 µg/kg, 32 µg/kg, and 100 µg/kg (dry wt). In the 28-d growth study, a significant increase in mortality was observed at 32 µg/kg and 100 µg/kg. In the 76-d reproduction study, there were significant adverse effects on survival (32 µg/kg and 100 µg/kg), growth (100 µg/kg), and reproduction (100 µg/kg). The overall lowest-observed-effect concentration was 32 µg/kg medetomidine. For this test substance the increased study duration did not increase the overall sensitivity of the test. The present study suggests that the predicted sediment environmental concentration (PECsediment ) of 0.003 µg/kg for medetomidine would not be expected to cause adverse effects on the life history of C. volutator.

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Section: Discussionmentioning

confidence: 93%