Incorporation of antimicrobial agents can be used to enhance the antibacterial effect of endodontic sealers

Gjorgievska, Elizabeta; Apostolska, Sonja; Dimkov, Aleksandar; Nicholson, John W.; Kaftandzieva, Ana

doi:10.1016/j.dental.2012.10.002

Cited by 39 publications

(58 citation statements)

References 28 publications

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“…The main components of Endofill sealer are zinc oxide and eugenol, which are bactericidal (20). Epoxy resin-based AH Plus can release formaldehyde or monomer residuals in the polymer materials (1). Its antimicrobial effect may be related to the release of bisphenol A diglycidyl ether during the polymerization process (21).…”

Section: Discussionmentioning

confidence: 99%

“…Endodontic sealers can have an antimicrobial effect depending on their chemical composition (1). The main components of Endofill sealer are zinc oxide and eugenol, which are bactericidal (20).…”

Section: Discussionmentioning

confidence: 99%

“…However, not all sealers have this property, making the development of new materials with antimicrobial activity promising (1)(2)(3)(4).…”

Section: Highlightsmentioning

confidence: 99%

“…The success of endodontic treatment depends on controlling the root canal microbiota with appropriate chemical-mechanical preparation, canal obturation and coronal sealing (1)(2)(3)(4). This control is difficult because of the complexity of the root canal anatomy (5).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Incorporating Antimicrobial Nanomaterial and its Effect on the Antimicrobial Activity, Flow and Radiopacity of Endodontic Sealers

Teixeira¹,

Vidal²,

CASTRO³

et al. 2017

Eur Endod J

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Objective: This preliminary study aimed to evaluate the antimicrobial activity, flow and radiopacity of endodontic sealers with nanostructured silver vanadate decorated with silver nanoparticles (AgVO3). Methods:The minimum inhibitory concentration (MIC) of AgVO3 was evaluated against Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. Specimens were prepared from the following endodontic sealers: AH Plus (DENTSPLY DeTrey GmbH, Konstanz, Germany), Sealapex (Sybron Endo, Orange, CA, USA), Sealer 26 (DENTSPLY, Petrópolis, Brazil) and Endofill (DENTSPLY, Petrópolis, Brazil), with concentrations of 0%, 2.5%, 5% and 10% of AgVO3. Agar diffusion was used to evaluate the materials after 48 hours and 7 days (n=6). Flow (n=6) and radiopacity (n=9) were evaluated. The data were analysed by analysis of variance (ANOVA) and the Tukey honestly significant difference (HSD) (α=0.05). Results: The MIC of AgVO3 was 500 µg/mL for E. faecalis and 31.25 µg/mL for P. aeruginosa and E. coli. The AgVO3 did not influence the antimicrobial activity of AH Plus against E. faecalis (P>0.05) but did promote this activity for Sealapex (P<0.01). Moreover, this activity increased for Endofill from 2.5% and for Sealer 26 from 5% (P<0.05). Against P. aeruginosa, only AH Plus and Endofill 10% inhibited zone formation (P<0.01). The antimicrobial activity of Endofill increased from 2.5% against E. coli (P<0.01). Sealapex 5% and 10% (P<0.01), Sealer 26 10% and AH Plus promoted antimicrobial activity against E. coli. An increase in the zone of inhibition occurred between 48 hours and 7 days in the Sealapex 10% and Endofill 5% groups against E. coli. The flow of AH Plus and Endofill decreased with the increase of AgVO3 (P<0.05), and the flow of Sealer 26 and Sealapex was not affected (P>0.05). The radiopacity of AH Plus increased with AgVO3 (P<0.05). Endofill 5% and 10% did not differ from the control Endofill (P>0.05). The incorporation of AgVO3 did not influence the radiopacity of Sealer 26 (P>0.05). The incorporation of 2.5% and 5% AgVO3 reduced the radiopacity of Sealapex (P<0.05). Conclusion: Adding AgVO3 may increase the antimicrobial effect of endodontic sealers without major changes in their physicochemical properties.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…However, not all sealers have this property, making the development of new materials with antimicrobial activity promising (1)(2)(3)(4).…”

Section: Highlightsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incorporating Antimicrobial Nanomaterial and its Effect on the Antimicrobial Activity, Flow and Radiopacity of Endodontic Sealers

Teixeira¹,

Vidal²,

CASTRO³

et al. 2017

Eur Endod J

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“…Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium salt that is widely used as the active component of oral antiseptics due to its broad antimicrobial spectrum with a particularly strong bactericidal effect against gram-positive bacteria [14][15][16] . Namba et al 11) showed that a simple mixture of CPC with a light-curable resin led to growth inhibition of Streptococcus mutans attached to the resin surface, although no inhibitory effect was observed against bacteria that were not attached to the surface.…”

Section: Introductionmentioning

confidence: 99%

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

et al. 2016

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Application of hydroxyapatite (HAp) nanoparticles to repair damaged enamel has attracted recent attention. In this study, HAp nanoparticles with various morphologies (spherical, short-rod, long-rod and fiber morphologies) were synthesized via chemical precipitation methods without the addition of template molecules, and the adsorption/desorption behaviors of a cationic antibacterial agent, cetylpyridinium chloride (CPC), on the HAp nanoparticles were evaluated. The adsorption of CPC on each HAp nanoparticle showed Langmuir-type adsorption, and the short-rod/long-rod HAp nanoparticles showed thermodynamically more stable adsorption of CPC than that with the spherical/fiber HAp nanoparticles. The desorption rate of CPC from the short-rod/long-rod HAp nanoparticles was slower than that of the spherical/fiber HAp nanoparticles. The HAp nanoparticles with different CPC release profiles presented here have potential applications as nanoparticulate enamel repair agents with antibacterial properties.

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Controlled release of metronidazole from composite poly-ε-caprolactone/alginate (PCL/alginate) rings for dental implants

et al. 2013

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Incorporation of antimicrobial agents can be used to enhance the antibacterial effect of endodontic sealers

Cited by 39 publications

References 28 publications

Incorporating Antimicrobial Nanomaterial and its Effect on the Antimicrobial Activity, Flow and Radiopacity of Endodontic Sealers

Incorporating Antimicrobial Nanomaterial and its Effect on the Antimicrobial Activity, Flow and Radiopacity of Endodontic Sealers

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

Controlled release of metronidazole from composite poly-ε-caprolactone/alginate (PCL/alginate) rings for dental implants

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