Incorporation of Bacterial Inhibitor into Resin Composite

Abstract

Attempts to produce resin composite with antibacterial properties by incorporation of an antibacterial agent such as chlorhexidine have been reported, but problems can arise due to release of the inhibitory agent from the composite. Such problems may include toxic effects, influence on mechanical properties, and loss of effectiveness. A new monomer, methacryloyloxydodecylpyridinium bromide (MDPB), was synthesized by combining an antibacterial agent and methacryloyl group. The monomer was incorporated into resin composite to develop a non-releasing antibacterial composite. The ability of composite incorporating MDPB to inhibit growth and plaque accumulation by Streptococcus mutans in vitro was assayed, elution of antibacterial components from the material was investigated, and the influence of incorporation of MDPB on the mechanical properties of composite was studied. Uncured MDPB revealed antibacterial activity against S. mutans and six other species of oral streptococci, with the minimum inhibitory concentration for S. mutans being comparable with that of triclosan. After composite incorporating MDPB was cured, no elution of the antibacterial components was observed from the material, even after 90 days' immersion in water or other solvents. Growth of S. mutans on agar under specimens of MDPB-containing composite was inhibited compared with controls. In a bacterial accumulation study, S. mutans accumulated to a lesser degree on the surface of composite incorporating MDPB (p < 0.05) than on control. Incorporation of MDPB had no significant influence on the mechanical properties of the composite.

Efectos sobre microdureza y grado de conversión de dos tipos de resinas sometidas a tratamientos de pospolimerización

“…Con el fin de disminuir la absorción de agua, se han propuesto otros sistemas entre los que se incluyen los análogos químicos del uretano dimetacrilato (udma), que poseen un grupo fenoximetil en la porción periférica o central como grupo alifático [23], [24], que al ser comparado con los sistemas habituales udma, reducen entre un 10-30% la absorción de agua; sin embargo, se ha reportado como efecto secundario la disminución de la resistencia comprensiva [25].…”

Study on antibacterial dental resin using tri-n-butyl(4-vinylbenzyl)phosphonium chloride

“…Our findings show that copolymers containing VP are unfavorable for denture base resins where high mechanical strength is demanded, but are strong enough for applications such as soft linings for dentures, as a primer for dentin and enamel adhesives, and as the matrix in a resin-modified glass ionomer cement. In addition, since VP shows antibacterial activity at low concentrations and the matrix in composite resin contains high-density cross linkages, it is thought that the introduction of VP into the matrix of a composite resin will not decrease the mechanical strength of the resin 9) .…”

“…The bond strength to enamel was clinically acceptable for orthodontic brackets, but was not effective on dentin. A new monomer, methacryloyloxydodecylpyridinium bromide, was synthesized, and investigated as an antibacterial agent [9][10][11][12][13] . Composite material containing the monomer inhibited the growth of S. mutans, and no elution of the antibacterial agent was observed from the material.…”

Conventional and adhesive luting cements

“…Nevertheless, a gap-free interface seems more important in preventing secondary caries than the release of fluoride or other substances such as 12-methacryloyloxydodecylpyridinium bromide (MDPB) [29,30] from materials alone [58,64] or the bioactive intrinsic potential of the adhesives [28].…”