Incorporation of bioactive glass in calcium phosphate cement: An evaluation

Rennó, Ana Cláudia Muniz; Watering, Floor C. J. van de; Nejadnik, M. Reza; Crovace, Murilo C.; Zanotto, Edgar Dutra; Wolke, Joop G.C.; Jansen, Jitske; Beucken, Jeroen J.J.P. van den

doi:10.1016/j.actbio.2012.11.009

Cited by 57 publications

(47 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other types of the dual setting formulations containing calcium orthophosphates are known as well [509,510,511]. A positive influence of polyamide fibers [512] and bioactive glass [513,514,515,516] is also known. Interestingly that reinforcement of self-setting formulations might be performed by infiltration of a preset composition by a reactive polymer and then cross-linking the polymer in situ [517].…”

Section: Reinforced Formulations and Concretesmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

View full text Add to dashboard Cite

In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

show abstract

Section: Reinforced Formulations and Concretesmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

View full text Add to dashboard Cite

show abstract

“…10 11 BG-supplemented CPCs exhibit higher degradation and bone formation in femoral condyle defects in rats. 10 In fact, BGs are some of the most promising bone regenerative materials in terms of their bone-bioactivity, reactivity, and degradability. 12 In particular, the release of Si, Ca and P ions has been observed to up-regulate gene expression in osteoprogenitor and mesenchymal stem cells, giving rise to rapid bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Odontogenesis and Angiogenesis via Bioactive Nanocomposite Calcium Phosphate Cements Through Integrin and VEGF Signaling Pathways

Lee¹,

Lee²,

El‐Fiqi³

et al. 2016

j biomed nanotechnol

View full text Add to dashboard Cite

Formulating self-setting calcium phosphate cements (CPCs) with secondary phases particularly in the nanoscale order holds great promise to improve biological properties. Here, we focus on the effect that bioactive glass nanoparticles (BGN) incorporated in CPC compositions can have on the proliferation, odontogenic differentiation, and angiogenic stimulation of stem cells derived from human dental pulp (HDPSCs). These odontogenic and angiogenic events are of special importance in the dentin-pulp regeneration processes. In comparison to pure CPCs, nanocomposite cements exhibit a significantly improved proliferation of HDPSCs, and the improvement is more significant as the BGN content increases. The nanocomposite cements substantially enhance the adhesion of cells, and significantly up-regulate odontogenic differentiation, including alkaline phosphatase (ALP) activity and the expressions of odontogenic genes (sialophosphoprotein, dentin matrix protein I, ALP, osteopontin and osteocalcin). Furthermore, the use of nanocomposite cements result in stimulation of angiogenic gene expression (VEGF, FGF-2, VEGFRs, PECAM-1, and VE-cadherin) and protein production (VEGF, VEGFR-1). The angiogenic stimulation by the HDPSCs significantly affects the endothelial cell behaviors, that is, the endothelial cell migration and the tubular network formation are substantially improved when treated with HDPSC-conditioned medium, particularly with the help of nanocomposite cements. The integrin and VEGF signaling pathways are reasoned for the stimulation of the odontogenesis and angiogenesis of cells, where the nanocomposite cements up-regulate the integrin subsets α1, α2, α3, and β1, and activate the integrin downstream signal pathways, such as p-FAK, p-Akt, p-paxillin, JNK, EK, and NF-κB, as well as other nuclear transcriptional factors, including CREB, STAT-3, and ELK-1. The current results indicate that the new formulation of the nanocomposite self-setting cements might provide some beneficial microenvironments for the regenerative processes of dentin-pulp complex tissues.

show abstract

“…Lin et al also showed that, by adding calcium silicate particles into CSCs, they were able to delay in vitro degradation and show more new bone formation compared with pure CSCs in in vivo rat models [15]. Studies have shown that the growth of newly formed bone is limited by the amount of space left after the degradation of the cement [16][17][18]. Nevertheless, a restriction of new bone growth due to a lack of space alone does not appear to be detrimental to the host, as long as the bone cement remains intact and forms a bioactive bond with the host bone [16].…”

Section: Requirements Of Ibcsmentioning

confidence: 99%

Nanomaterials: The Next Step in Injectable Bone Cements

Roohani‐Esfahani

Zreiqat

2014

Nanomedicine

View full text Add to dashboard Cite

Injectable bone cements (IBCs) are biocompatible materials that can be used as bone defect fillers in maxillofacial surgeries and in orthopedic fracture treatment in order to augment weakened bone due to osteoporosis. Current clinically available IBCs, such as polymethylmethacrylate and calcium phosphate cement, have certain advantages; however, they possess several drawbacks that prevent them from gaining universal acceptance. New gel-based injectable materials have also been developed, but these are too mechanically weak for load-bearing applications. Recent research has focused on improving various injectable materials using nanomaterials in order to render them suitable for bone tissue regeneration. This article outlines the requirements of IBCs, the advantages and limitations of currently available IBCs and the state-of-the-art developments that have demonstrated the effects of nanomaterials within injectable systems.

show abstract

Incorporation of bioactive glass in calcium phosphate cement: An evaluation

Cited by 57 publications

References 35 publications

Self-Setting Calcium Orthophosphate Formulations

Self-Setting Calcium Orthophosphate Formulations

Stimulation of Odontogenesis and Angiogenesis via Bioactive Nanocomposite Calcium Phosphate Cements Through Integrin and VEGF Signaling Pathways

Nanomaterials: The Next Step in Injectable Bone Cements

Contact Info

Product

Resources

About