Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation

Abstract

Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the fabrication of high‐quality homochiral MOF membranes remains challenging because of the difficulty in controlling growth of MOF membranes with chiral functionalities. A homochiral zeolitic imidazolate framework‐8 (ZIF‐8) membrane is reported for efficient chiral separation. The membrane is synthesized by incorporating a natural amino acid, l‐histidine (l‐His), into the framework of ZIF‐8. The homochiral l‐His‐ZIF‐8 membrane exhibits a good selectivity for the R‐enantiomer of 1‐phenylethanol over the S‐enantiomer, showing a high enantiomeric excess value up to 76 %.

Chiral Metal–Organic Framework d-His-ZIF-8@SiO2 Core–Shell Microspheres Used for HPLC Enantioseparations

“…The SiO 2 –COOH, d -his-ZIF-8, and d -his-ZIF-8@SiO 2 were characterized by PXRD, SEM, FT-IR, and CD. As can be seen from Figure , the successful synthesis of ZIF-8 nanocrystals was demonstrated by comparing the PXRD pattern of the synthesized ZIF-8 with the simulated pattern . Moreover, the characteristic peaks of the synthesized d -his-ZIF-8 nanocrystals well match with the ZIF-8 pattern, indicating that the crystalline structure of d -his-ZIF-8 nanocrystals coincides with the structure of ZIF-8 nanocrystals.…”

“…Synthesis of ZIF-8. The ZIF-8 was synthesized in accordance with Wang et al 39 2-Methylimidazole (0.65 g) and Zn(NO 3 ) 2 •6H 2 O (0.294 g) were dissolved in 10 mL of methanol, separately. The solution of Zn 2+ was gradually added into the 2-methylimidazole solution, stirring at 25 °C for 24 h. The resulting product was collected by centrifugation.…”

The role of l-histidine as molecular tongs: a strategy of grasping Tb3+ using ZIF-8 to design sensors for monitoring an anthrax biomarker on-the-spot

“…The peak shi was attributed to the incorporation of the amino acid, His, which caused slight lattice distortion in the crystal according to reported literature. [35][36][37] Moreover, the XRD peaks of His@ZIF-8/Tb 3+ remained unchanged when compared with those of His@ZIF-8. This may be due to the coordination of Tb 3+ with only the exposed carboxyl and amino groups of His@ZIF-8 without being incorporated into its framework.…”

“…His@ZIF-8 was prepared according to a recent report. 37 Briefly, 3.0 mmol His was dissolved in 40 mL deionized water. 250 μL of TEA was then added into the His solution and stirred for 5 min.…”

Amino Acid Functionalized Crystalline Porous Polymers

“…作者将 其用于外消旋体 2-甲基-2,4-戊二醇的手性识别和吸附 分离实验, 手性拆分 ee 值为 35.5%. 王焕庭课题组 [47] 报 道了 L-组氨酸修饰的 MOF 膜-L-His-ZIF-8/AAO, 其手 性拆分外消旋 1-苯基乙醇的 ee 值为 76%. 由于手性 MOFs 在多孔基底上直接生长成膜时通常会形成一定的 缺陷, 导致分离效果不佳.…”