Incorporation of no-carrier added 200,203 Pb and 200,201,202 Tl in calcium alginate and hesperidin incorporated calcium alginate beads

Sarkar, Kangkana; Lahiri, Susanta; Sen, Kamalika

doi:10.1016/j.apradiso.2016.12.022

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Thus, the adsorption technique was applied to the polymer-rich phase. Calcium alginate beads are one of the most popular means to adsorb various types of drugs and medicines. − Thus, to remove the PPIs from the polymer-rich phase, we have prepared the Ca-alginate beads as previously reported. , Briefly, the aqueous solution of sodium alginate (3% w/v) was slowly added dropwise to a 20% (w/v) aqueous solution of calcium chloride dihydrate with the help of a buret at 4 °C with constant stirring on a magnetic stirrer. The obtained beads were kept in the mother liquor at 4 °C overnight and then washed with triple-distilled water.…”

Section: Methodsmentioning

confidence: 99%

Amino Acid and Block Copolymer-Based ABS: An Efficient Extraction Tool for PPIs and Consequent Recovery of the Polymer

Das

Sen

2022

J. Chem. Eng. Data

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Aiming to construct a biocompatible aqueous biphasic system (ABS), amino acids and a block copolymer, poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) (PPG-PEG-PPG), have been employed. Glycine and l-proline can successfully salt out PPG-PEG-PPG and can form a biphase even at room temperature, whereas l-alanine requires the temperature to be increased to at least 318 K at normal atmospheric pressure to form an ABS with the block copolymer. The phase diagrams for all the systems have been constructed using a turbidometric method at different temperatures, and the corresponding binodal graphs are plotted with the help of the Merchuk equation. An increase in temperature leads to an increase in the biphasic region. The tie line lengths, slope of the tie lines, and compositions of both the phases of the corresponding ABSs have been determined using the lever arm rule. The presence of amino acids in the place of ionic salts as one of the phase-forming components makes the ABSs eligible to extract medically relevant molecules. Herein, proton pump inhibitors (PPIs), “one of the most prescribed medicines in the world,” are extracted using the newly designed amino acid and block copolymer-based ABSs. The complete extractions of rabeprazole and pantoprazole are achieved using the glycine-based ABS, whereas ∼83% of esomeprazole is extracted with the same ABS. The extraction efficacies of the other two amino acid-based ABSs are also noticeable. After the extraction, the block copolymer-rich phase is regenerated using thermoseparation and adsorption techniques, which makes the ABS a much greener and cost-effective methodology in extraction chemistry.

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Section: Methodsmentioning

confidence: 99%

Amino Acid and Block Copolymer-Based ABS: An Efficient Extraction Tool for PPIs and Consequent Recovery of the Polymer

Das

Sen

2022

J. Chem. Eng. Data

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“…To prepare Ca-alginate beads, 3% (w/v) sodium alginate solution was slowly added dropwise into a 20% (w/v) calcium chloride dehydrate solution at 4 °C with constant stirring by a magnetic stirrer. The beads were kept in mother liquor overnight and washed with triple-distilled water before experiment. , To an aliquot of 1 mL of the polymer-rich phase of ABS, 25 beads of Ca alginate were added to remove the desired drugs from the polymer.…”

Section: Methodsmentioning

confidence: 99%

“…The beads were kept in mother liquor overnight and washed with tripledistilled water before experiment. 30,31 To an aliquot of 1 mL of the polymer-rich phase of ABS, 25 beads of Ca alginate were added to remove the desired drugs from the polymer.…”

Section: % Extraction Prednisolonementioning

confidence: 99%

Poly(propylene glycol) vs Sugar Alcohol-Based Aqueous Biphasic System to Extract Drugs and Subsequent Recovery of the Polymer

Das

Paik²,

Sen

2021

J. Chem. Eng. Data

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A carbohydrate-based aqueous biphasic system (ABS) has been designed by adding an aqueous solution of sugar alcohols (D-mannitol and glycerol) to poly(propylene glycol) (PPG#400). The phase diagrams of the ABSs have been constructed using the turbidometric titration method at 309 K. The tie-line lengths and the slope of tie lines of the system have been obtained using the gravimetric method. The use of sugar alcohol to replace the salt-rich phase for phase separation makes the ABS apt for extracting different molecules of biological relevance. Using one of these newly constructed eco-friendly ABSs, D-mannitol vs PPG#400, the extraction behaviors of Ivermectin and Doxycycline (which have been extensively used to treat COVID-19 patients) were studied at different pH values. About 90% of Ivermectin and 70% of Doxycycline has been extracted to the polymer-rich phase of ABS at pH 7 in single extraction. The extraction patterns of these two drugs remain almost the same even in the presence of Lascorbic acid and zinc acetate, which are also administered as combination drugs in the treatment of COVID-19. We have also studied the extraction behavior of Prednisolone, a corticosteroid, which also is widely recommended to particularly treat the severity of the cytokine storm that arises in many patients at the third phase of COVID-19. Complete extraction of Prednisolone has been achieved at pHs 3 and 5, and ∼97% of extraction has been achieved at pH 7. The objective of such extraction is to design cleaner methods of remediation of these drugs to minimize their exposure to the environment that may lead to drug resistance in the environment. We have also recovered the polymer using thermoseparation and adsorption techniques after extraction experiments to make the method environmentally as well as economically viable.

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Production, separation and embedment of no-carrier added 93mMo in iron-doped calcium alginate beads from 7Li irradiated yttrium target

Sen

Sarkar

Lahiri

2017

J Radioanal Nucl Chem

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Incorporation of no-carrier added 200,203 Pb and 200,201,202 Tl in calcium alginate and hesperidin incorporated calcium alginate beads

Cited by 5 publications

References 34 publications

Amino Acid and Block Copolymer-Based ABS: An Efficient Extraction Tool for PPIs and Consequent Recovery of the Polymer

Amino Acid and Block Copolymer-Based ABS: An Efficient Extraction Tool for PPIs and Consequent Recovery of the Polymer

Poly(propylene glycol) vs Sugar Alcohol-Based Aqueous Biphasic System to Extract Drugs and Subsequent Recovery of the Polymer

Production, separation and embedment of no-carrier added 93mMo in iron-doped calcium alginate beads from 7Li irradiated yttrium target

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