Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth

Ku, Kuan-Lin; Wu, Yushan; Wang, Chi-Yun; Hong, Ding-Wei; Chen, Zong-Xing; Huang, Ching An; Chu, I‐Ming; Lai, Po‐Liang

doi:10.1098/rsos.182060

Cited by 26 publications

(12 citation statements)

References 31 publications

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“…According to that standard, the oHAP-BC group included only one sample (oHAP5-BC that contained a low loading of oHAP, at 5 wt.%) that met the requirements, while all six samples of the vHAP-BC and gHAP-BC groups met the ISO 5833 requirements for bending and compressive properties, indicating the effectiveness of organic functional HAPs when applied in bone cements. Although there is no requirement for TS, TM and CM in the ISO 5833 standard, the obtained results for the tensile properties and compressive modulus in this study are in the tolerance range observed for commercial bone cements in other works [25,40,[54][55][56][57].…”

Section: Mechanical Propertiessupporting

confidence: 49%

PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization

et al. 2021

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In this study, vinyltrimethoxysilane-treated hydroxyapatite (vHAP) and PMMA-grafted HAP (gHAP) were successfully prepared from original HAP (oHAP). Three kinds of HAP (oHAP, vHAP and g HAP) were used as additives for the preparation of three groups of HAP-modified PMMA bone cements (oHAP-BC, vHAP-BC and gHAP-BC). The setting, bending and compression properties of the bone cements were conducted according to ISO 5833:2002. The obtained results showed that the maximum temperature while curing the HAP-modified bone cements (HAP-BCs) decreased from 64.9 to 60.8 °C and the setting time increased from 8.1 to 14.0 min, respectively, with increasing HAP loading from 0 to 15 wt.%. The vHAP-BC and gHAP-BC groups exhibited higher mechanical properties than the required values in ISO 5833. Electron microscopy images showed that the vHAP and gHAP nanoparticles were dispersed better in the polymerized PMMA matrix than the oHAP nanoparticles. FTIR analysis indicated the polar interaction between the PO4 groups of the HAP nanoparticles and the ester groups of the polymerized PMMA matrix. Thermal gravimetric analysis indicated that mixtures of ZrO2/HAPs were not able to significantly improve the thermal stability of the HAP-BCs. DSC diagrams showed that the incorporation of gHAP to PMMA bone cement with loadings lower than 10 wt.% can increase Tg by about 2.4 °C.

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Section: Mechanical Propertiessupporting

confidence: 49%

PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization

et al. 2021

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“…PMMA/BAG composites have shown good bioactivity as well as enhanced mechanical strength [148,161,162]. For instance, composite of PMMA and silicate-based bioceramic showed good cell attachment, proper setting time and high mechanical strength as compared to PMMA alone [161].…”

Section: Polymeric Matrix Composite Materialsmentioning

confidence: 99%

“…Ku et al prepared PMMA composite with surface-modified HA, in order to enhance ceramic-polymer phase interaction. HA nanoparticles were modified with either ethylene glycol or ɛ-caprolactone before blending with PMMA; this enhanced the compressive strength of the composite along with improved bioactive surface [162]. Furthermore, PMMA/BAG custom-made craniofacial implants were clinically applied to repair calvarial and facial defects; 5-year follow-up found patients' clinical recovery with good aesthetic and functional outcome [113].…”

Section: Polymeric Matrix Composite Materialsmentioning

confidence: 99%

3D printed composite materials for craniofacial implants: current concepts, challenges and future directions

Jindal

Manzoor

Haslam³

et al. 2020

Int J Adv Manuf Technol

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Millions of craniofacial surgeries are performed annually worldwide for craniofacial bones’ replacement and augmentation. This represents a significant economic burden as well as aesthetic expectations. Autografts and allografts are the first choice for treatment of craniofacial defects; however, their limited availability and difficulty to shape have led to investigation for alternative strategies. Biomaterial-based approaches have been used for implantation as they have ample supply but their processing through conventional technologies present several drawbacks; the major one relates to the poor versatility towards the production of patient-specific implants. Additive manufacturing has gained considerable attention during the last decade, as it allows the manufacturing of implants according to patient need. Biomaterial implants can be additively manufactured but have one or more limitations of stress shielding, radiopacity, high strength to weight ratio and limited bone integration. Over the last few decades, composites are investigated to surmount the limitations with traditional implants and also improve their bone integration. This review provides an overview of the most recent polymeric composite-based biomaterials that have been used in combination with 3D printing technology for the development of patient-specific craniofacial implants. Starting with the conventional treatments, biomaterials available for the craniofacial implants, the additive manufacturing rationale are discussed. Also, the main challenges still associated with 3D printing of polymer-based composites are critically reviewed and the future perspective presented.

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“…With the development of biomaterial medicine, artificial bone scaffolds served as an alternative solution have shown promising potential to treat periodontal tissue bone defect. Many natural and synthetic materials such as collagen, glass ceramics, calcium sulfate, natural and artificial polymers are considered cell carriers and bone conduction materials [ 8 ]. Like the mineral phase of bone tissue, β-tricalcium phosphate (β-TCP) has appropriate biocompatibility, bioactivity, and osteoconductive ability.…”

Section: Introductionmentioning

confidence: 99%

Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis

Tan

et al. 2021

J Mater Sci: Mater Med

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Periodontitis is a progressive infectious inflammatory disease, which leads to alveolar bone resorption and loss of periodontal attachment. It is imperative for us to develop a therapeutic scaffold to repair the alveolar bone defect of periodontitis. In this study, we designed a new composite scaffold loading metformin (MET) by using the freeze-drying method, which was composed of β-tricalcium phosphate (β-TCP), chitosan (CTS) and the mesoporous silica (SBA-15). The scaffolds were expected to combine the excellent biocompatibility of CTS, the good bioactivity of β-TCP, and the anti-inflammatory properties of MET. The MET-loaded β-TCP/CTS/SBA-15 scaffolds showed improved cell adhesion, appropriate porosity and good biocompatibility in vitro. This MET composite scaffold was implanted in the alveolar bone defects area of rats with periodontitis. After 12 weeks, Micro-CT and histological analysis were performed to evaluate different degrees of healing and mineralization. Results showed that the MET-loaded β-TCP/CTS/SBA-15 scaffolds promoted alveolar bone regeneration in a rat model of periodontitis. To our knowledge, this is the first report that MET-loaded β-TCP/CTS/SBA-15 scaffolds have a positive effect on alveolar bone regeneration in periodontitis. Our findings might provide a new and promising strategy for repairing alveolar bone defects under the condition of periodontitis.

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Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth

Cited by 26 publications

References 31 publications

PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization

PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization

3D printed composite materials for craniofacial implants: current concepts, challenges and future directions

Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis

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