Incorporation of ultraviolet (UV) absorbing nanoparticles in contact lenses for Class 1 UV blocking

Gause, Samuel; Chauhan, Anuj

doi:10.1039/c5tb01532d

Cited by 23 publications

(13 citation statements)

References 13 publications

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“…For instance, 100 μm thick PHEMA gels loaded with 0, 0.5, and 0.63 wt % showed ca. 93.1%, 13.8%, and 5.9% UVA transmittance, and 89.1%, 4.2%, and 0.4% UVB transmittance, respectively …”

Section: Polymeric Materials For Ocular Surface Applicationsmentioning

confidence: 99%

“…93.1%, 13.8%, and 5.9% UVA transmittance, and 89.1%, 4.2%, and 0.4% UVB transmittance, respectively. 81 Water-soluble cerium oxide nanoparticles (ceria, CeNPs) were incorporated in PHEMA-based CLs for reactive oxygen species (ROS) scavenging on the ocular surface (Figure 5). ROS (e.g., superoxide anions, singlet oxygen, hydroxyl radicals, and hydrogen peroxide) 82,83 can be generated under physiological conditions; however, excessive ROS amounts can cause many eye diseases, including cataracts, uveitis, and ocular surface diseases (e.g., dry eye syndrome) because of oxidative damage to DNA, proteins, and lipids.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric Materials for Eye Surface and Intraocular Applications

Karayilan

Clamen²,

Becker

2021

Biomacromolecules

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Ocular applications of polymeric materials have been widely investigated for medical diagnostics, treatment, and vision improvement. The human eye is a vital organ that connects us to the outside world so when the eye is injured, infected, or impaired, it needs immediate medical treatment to maintain clear vision and quality of life. Moreover, several essential parts of the eye lose their functions upon aging, causing diminished vision. Modern polymer science and polymeric materials offer various alternatives, such as corneal and scleral implants, artificial ocular lenses, and vitreous substitutes, to replace the damaged parts of the eye. In addition to the use of polymers for medical treatment, polymeric contact lenses can provide not only vision correction, but they can also be used as wearable electronics. In this Review, we highlight the evolution of polymeric materials for specific ocular applications such as intraocular lenses and current state-of-the-art polymeric systems with unique properties for contact lens, corneal, scleral, and vitreous body applications. We organize this Review paper by following the path of light as it travels through the eye. Starting from the outside of the eye (contact lenses), we move onto the eye’s surface (cornea and sclera) and conclude with intraocular applications (intraocular lens and vitreous body) of mostly synthetic polymers and several biopolymers. Initially, we briefly describe the anatomy and physiology of the eye as a reminder of the eye parts and their functions. The rest of the Review provides an overview of recent advancements in next-generation contact lenses and contact lens sensors, corneal and scleral implants, solid and injectable intraocular lenses, and artificial vitreous body. Current limitations for future improvements are also briefly discussed.

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“…For instance, 100 μm thick PHEMA gels loaded with 0, 0.5, and 0.63 wt % showed ca. 93.1%, 13.8%, and 5.9% UVA transmittance, and 89.1%, 4.2%, and 0.4% UVB transmittance, respectively …”

Section: Polymeric Materials For Ocular Surface Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymeric Materials for Eye Surface and Intraocular Applications

Karayilan

Clamen²,

Becker

2021

Biomacromolecules

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“…Since long‐term UV exposure can cause ocular complications, such as cataracts and retinal damage, it is necessary to develop new methods for embedding UV‐blockers into contact lenses. Gause and Chauhan [49] proposed the addition of UV‐absorbing nanoparticles (NPs) to contact lenses to block UV rays. By polymerising a mixture of monomers and NPs, the UV‐absorbing NPs are added to ethyl methacrylate (HEMA) and a silicone gel, and the NPs are well dispersed in the HEMA monomer to form a completely transparent gel that provides excellent UV protection.…”

Section: Anti‐uv Hydrogelmentioning

confidence: 99%

Environment adaptive hydrogels for extreme conditions: a review

Jiang

2019

Biosurface and Biotribology

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Hydrogels have attracted extensive attention due to their excellent swellability, permeability, and biocompatibility. In recent years, the demand for multifunctional hydrogels has been on the increase; there is also an increased need to utilise hydrogels in more varied and extreme applications, such as low temperature, anoxic environment, ultraviolet damage, burns, and the marine environment. Furthermore, traditional hydrogel materials cannot meet the requirements of the application in extreme environments. Therefore, it is necessary to design and develop hydrogels that are adaptable to certain extreme conditions. This review summarises recent advances in hydrogels that meet application requirements under extreme conditions, particularly in the biomedical field and prospects for their future development.

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“…Therefore, UV-blocking films have attracted increased attention from researchers for applications in diverse fields, such as electronics, food packaging, and windshields (Babaei-Ghazvini et al 2018;Gause and Chauhan 2016;Shen et al 2020;Yun et al 2010). Nowadays, a variety of UV-blocking films have been developed with great properties (Bahramian 2020;Cohen et al 2017b;Guo et al 2017;Hu et al 2020;Wang et al 2012;Zhou et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Biodegradable and transparent films with tunable UV-blocking property from Lignocellulosic waste by a top-down approach

Song

Chen

et al. 2021

Cellulose

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As over exposure of the earth to ultraviolet (UV) light and increased amount of petroleum-based plastic waste, biodegradable UV-blocking materials are desired for diverse sustainable applications. Xylose residue, as the byproduct of xylitol production from corn cobs, is mainly composed of cellulose and lignin. Here, we develop a series of xylose residue films through a top-down approach (i.e., tunable delignification and regeneration) without any additional additives. The treated xylose residues with lignin content of 4.4-29.7% are used to prepare regenerated films, which exhibit excellent UV-blocking capability: 68.6-99.2% for UVB (290-320 nm) and 47.1-98.2% for UVA (320-400 nm). Moreover, these films remain a great optical transparency (50.6-86.6%) and show enhanced water vapor permeability (2.17-2.76 ×10 -11 g•cm•cm -2 •s -1 •mmHg -1 ), surface hydrophobicity (water contact angle=72.3-86.4°), and thermal stability. Overall, our sustainable UV-blocking films have potential applications in the fields of electronics, food packaging, and windshields, etc. This study provides new insights into converting xylose residue directly to high value-added functional bioproducts.

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Incorporation of ultraviolet (UV) absorbing nanoparticles in contact lenses for Class 1 UV blocking

Abstract: UV blocking nanoparticles 10 to 1000 nm in diameter have been created by polymerization of emulsions and loaded into contact lens materials.

Cited by 23 publications

References 13 publications

Polymeric Materials for Eye Surface and Intraocular Applications

Polymeric Materials for Eye Surface and Intraocular Applications

Environment adaptive hydrogels for extreme conditions: a review

Biodegradable and transparent films with tunable UV-blocking property from Lignocellulosic waste by a top-down approach

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