Increase in chromogranin A- and serotonin-positive cells in pouch mucosa of patients with ulcerative colitis undergoing proctocolectomy

Abstract

We here demonstrated neuroendocrine cell hyperplasia in pouch mucosa. Further studies are needed to clarify the pathophysiological implication of this finding.

Clinicopathological Correlations Of Neuroendocrine Cell Hyperplasia In Ulcerative Colitis Patients

“…EEC are considered key players in the pathogenesis of inflammatory bowel disease (IBD) and possible therapeutic targets in these patients 5 . NEC hyperplasia has been described by various authors in patients with ulcerative colitis, Crohn's disease, microscopic colitis and irritable bowel syndrome, probably as response to inflammation [6][7][8][9][10][11][12][13][14][15] . Some authors also reported the presence of very small incidental NEC proliferations in ulcerative colitis patients 10,16 .…”

Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands

“…Dysregulation of the 5-HT system has been demonstrated to play a role in the pathophysiology of gut disorders including IBD. Interestingly, expression of mucosal SERT is decreased in experimental colitis [27,28] as well as in IBD patients [29][30][31][32]. Conversely, SERT KO mice which lack high affinity transport of 5-HT into the intracellular compartment are more susceptible to intestinal inflammation [33,34].…”