Increase in complement component C3 is an early response to experimental magnesium deficiency in rats

Bussière, Françoise; Tridon, A.; Zimowska, Wioletta; Mazur, Andrzej; Rayssiguier, Yves

doi:10.1016/s0024-3205(03)00291-1

Cited by 33 publications

(25 citation statements)

References 11 publications

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“…CRP production by liver is regulated by TNF- α and IL-6(9). A well-documented link between Mg deficiency and acute inflammatory response in animal models characterized by leukocyte and macrophages activation, release of inflammatory cytokines and acute phase proteins, and excessive production of free radicals has also been reported in experimental settings(35, 36). Studies based on infrared spectrometry techniques have also demonstrated substantial alteration in secondary structures of human CRP in presence of Mg ions(37).…”

Section: Discussionmentioning

confidence: 92%

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review

2014

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Objectives To quantitatively summarize the association of dietary magnesium (Mg) intake with serum C-reactive protein (CRP) levels in the general population. Methods Observational and experimental studies through February 2013 were reviewed in PubMed and EMBASE. Additional information was retrieved through Google or hand search of related reference lists. The main outcome is either adjusted geometric mean of CRP or odds ratio (OR) of having serum CRP≥3 mg/L. Meta-regression was used to determine the linear association of dietary Mg intake and adjusted geometric means of CRP levels. A fixed-effects model was used to pool ORs of interest, comparing those in the lowest with those in the highest group of dietary Mg intake. Results A dataset derived from seven cross-sectional studies including 32,918 participants was quantitatively assessed. A weighted inverse association between Mg intake and serum CRP levels was observed[β coefficient: −0.0028; 95% CI, −0.0043 to −0.0013; P for trend=0.001] from four cross-sectional studies. The pooled OR (95%CI) of having CRP≥3 mg/L was 1.49(1.18 to 1.89) comparing the lowest to the highest group of Mg intake from three studies with data available. Qualitative assessment among five intervention studies also showed a potential beneficial effect of Mg intake on serum CRP levels. Conclusion This meta-analysis and systematic review indicate that dietary Mg intake is significantly and inversely associated with serum CRP levels. The potential beneficial effect of Mg intake on chronic diseases may be, at least in part, explained by inhibiting inflammation.

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Section: Discussionmentioning

confidence: 92%

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review

2014

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“…In animals, several studies have shown that magnesium deprivation causes excessive production and release of proinflammatory molecules such as tumor necrosis factor (TNF)-␣, IL-1␤, IL-6, vascular cell adhesion molecule (VCAM)-1, and plasminogen activator inhibitor (PAI)-1; increased circulating inflammatory cells (leukocyte and macrophage activation), and an increased hepatic production and release of acute phase proteins (i.e. complement, ␣2-macroglobulin, fibrinogen) [29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease

Barbagallo

Belvedere²,

Bella³

et al. 2011

Magnesium Research

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Magnesium deficiency is present in several chronic, age-related diseases, including cardiovascular, metabolic and neurodegenerative diseases. Alzheimer's disease (AD) is the most common cause of dementia. The aim of the present study was to study magnesium homeostasis in patients with mild to moderate AD. One hundred and one elderly (≥65 years) patients were consecutively recruited (mean age: 73.4±0.8 years; M/F: 42/59). In all patients, a comprehensive geriatric assessment was performed including cognitive and functional status. Admission criteria for the AD group (diagnosed according to the DSM-IV and the NINCDS-ADRDA criteria) included: mild to moderate cognitive impairment (MMSE score: 11-24/30, corrected for age and education). Blood samples were analyzed for serum total magnesium (Mg-tot) and serum ionized magnesium (Mg-ion). AD patients had significantly lower MMSE scores (20.5±0.7 vs 27.9±0.2; p<0.001), and for the physical function tests. Mg-ion was significantly lower in the AD group as compared to age-matched control adults without AD (0.50±0.01 mmol/L vs 0.53±0.01 mmol/L; p<0.01). No significant differences were found in Mg-tot between the two groups (1.91±0.03 mEq/L vs 1.95±0.03 mEq/L; p=NS). For all subjects, Mg-ion levels were significantly and directly related only to cognitive function (Mg-ion/MMSE r=0.24 p<0.05), while no significant correlations were found in this group of patients between magnesium and ADL or IADL. Our results show the presence of subclinical alterations in Mg-ion in patients with mild to moderate AD.

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“…Ca deficiency has protective effect for Mg deficiency-induced inflammation [80] , and abnormal Ca hemostasis that occurred during magnesium deficiency may exacerbate immune stress response at body level [81] . Another study indicated that at high Mg concentration (up to 8.0 mmol/L) in vitro , the leukocyte activation was diminished, probably due to the antagonist relationship between magnesium and calcium [82] . Taken together, the effect of Mg on inflammation is likely to be exerted by Mg/Ca antagonism.…”

Section: Bio-adaptation Between Mg Stent and Local Microenvironmentmentioning

confidence: 99%

Bio-Adaption between Magnesium Alloy Stent and the Blood Vessel: A Review

Zhao

Betts

et al. 2016

Journal of Materials Science & Technology

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Biodegradable magnesium (Mg) alloy stents are the most promising next generation of bio-absorbable stents. In this article, we summarized the progresses on the in vitro studies, animal testing and clinical trials of biodegradable Mg alloy stents in the past decades. These exciting findings led us to propose the importance of the concept “bio-adaption” between the Mg alloy stent and the local tissue microenvironment after implantation. The healing responses of stented blood vessel can be generally described in three overlapping phases: inflammation, granulation and remodeling. The ideal bio-adaption of the Mg alloy stent, once implanted into the blood vessel, needs to be a reasonable function of the time and the space/dimension. First, a very slow degeneration of mechanical support is expected in the initial four months in order to provide sufficient mechanical support to the injured vessels. Although it is still arguable whether full mechanical support in stented lesions is mandatory during the first four months after implantation, it would certainly be a safety design parameter and a benchmark for regulatory evaluations based on the fact that there is insufficient human in vivo data available, especially the vessel wall mechanical properties during the healing/remodeling phase. Second, once the Mg alloy stent being degraded, the void space will be filled by the regenerated blood vessel tissues. The degradation of the Mg alloy stent should be 100% completed with no residues, and the degradation products (e.g., ions and hydrogen) will be helpful for the tissue reconstruction of the blood vessel. Toward this target, some future research perspectives are also discussed.

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Increase in complement component C3 is an early response to experimental magnesium deficiency in rats

Cited by 33 publications

References 11 publications

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review

Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease

Bio-Adaption between Magnesium Alloy Stent and the Blood Vessel: A Review

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