Increase in cytokine production (IL-1β, IL-6, TNF-α but not IFN-γ, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis

Zheng, SX; Vrindts, Y; López, Miguel Fraile; Groote, D. De; Zangerle, P. F.; Collette, Julien; Franchimont, Nathalie; Geenen, Vincent; Albert, Adelin; Reginster, Jean‐Yves

doi:10.1016/s0378-5122(96)01080-8

Cited by 137 publications

(84 citation statements)

References 40 publications

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“…In this context, a sufficient load of antioxidants supplied by a diet rich in olive oil may prevent bone loss through the scavenging of free radicals. The anti-inflammatory components present in olive oil may also act by averting the increased plasma concentration of proinflammatory cytokines (interleukin-6, tumour necrosis factor-a) involved in bone resorption among postmenopausal women (Zheng et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Dietary fat intake and the risk of osteoporotic fractures in the elderly

et al. 2007

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Objective: To explore the association between fat intake, serum lipids and the risk of osteoporotic fractures in the elderly. Design: A hospital-based case-control study. Setting: The study was conducted at a tertiary centre and referral hospital for the province of Jaén (Spain). Subjects: Cases (n ¼ 167) were patients aged 65 years or more with a low-energy fracture selected from the population attended at the hospital. Controls (patients without antecedents of any fracture) were 1:1 matched to cases by sex and age (n ¼ 167). Methods: Diet was assessed by a semiquantitative food frequency questionnaire. Serum total cholesterol and high-density lipoprotein (HDL) cholesterol were also measured. Results: Participants in the two upper quartiles of polyunsaturated fat (PUFA) intake showed an increased risk of fracture, with statistically significant differences with respect to the first quartile in the adjusted model (odds ratio (OR) ¼ 3.59; 95% confidence interval (CI) ¼ 1.06-12.1 and OR ¼ 5.88; 95% CI ¼ 1.38-25.02); P ¼ 0.01 for the trend test). A higher ratio of monounsaturated fat (MUFA) to PUFA was associated with a reduced risk of fracture (OR ¼ 0.20; 95% CI ¼ 0.07-0.60 for the fourth quartile; P ¼ 0.002 for the trend test). The intake of omega-6 fatty acids was associated with an elevated risk of fracture (OR ¼ 3.41; 95% CI ¼ 1.05-11.15 for the fourth quartile; P ¼ 0.01 for the trend test). HDL-cholesterol levels were inversely associated with the risk of fracture (test for trend P ¼ 0.03 across quartiles). Conclusions: PUFA intake was associated with an increased risk of osteoporotic fractures in the elderly, whereas a high ratio of MUFA:PUFA was associated with decreased risk.

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Section: Discussionmentioning

confidence: 99%

Dietary fat intake and the risk of osteoporotic fractures in the elderly

et al. 2007

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“…It has been suggested that mechanism of postmenopausal osteoporosis is, at least partly, mediated by modulation of cytokine production due to estrogen deficiency (14). Zheng and colleagues observed increased production of TNF-α, IL-1β and IL-6 in postmenopausal women with osteoporosis (15).…”

Section: Discussionmentioning

confidence: 99%

Possible association of psoriasis and reduced bone mineral density due to increased TNF-α and IL-6 concentrations

Kaštelan

Massari

et al. 2006

Medical Hypotheses

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“…Post-menopausal bone loss is also associated with an increase in IL-6 level, activation of the signalling pathway mediated by glycoprotein (gp)-130 by IL-6 and its soluble receptor is historically known as a pivotal mechanism for the regulation of osteoclastogenesis (Zheng et al, 1997). IL-6 is not essential for bone resorption, however, IL6KO mice are protected against ovariectomy induced bone loss, and this finding, together with the observation of increased level of IL-6 after menopause in women, may suggest a peculiar role for IL-6 in bone loss due to estrogen deprivation.…”

Section: Estrogen Deficiency and Cytokinesmentioning

confidence: 99%

“…Gao et al, 2007;Grewal and Flavell, 1996;Kumru et al, 2004;Li et al, 2010;Porter et al, 2001;Rogers and Eastell, 2001;Roggia et al, 2001;Zheng et al, 1997).…”

Section: Estrogen Deficiency and Cytokinesmentioning

confidence: 99%

The immune system and postmenopausal osteoporosis

D’Amelio

2013

Immunological Investigations

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This is an author version of the contribution published on:Questa è la versione dell'autore dell'opera: The immune system and postmenopausal osteoporosis.D 'Amelio P. Immunol Invest. 2013;42(7):544-54. doi: 10.3109/08820139.2013.822764 AbstractIn the last decay investigators have paid attention to the relation between immune system, estrogen deficiency and bone loss, some of the pathways have been clarified whereas others remain an unexplained challenge. This review summarizes the evidences that link immune cells, estrogen loss and osteoclast formation and activity.

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Increase in cytokine production (IL-1β, IL-6, TNF-α but not IFN-γ, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis

Cited by 137 publications

References 40 publications

Dietary fat intake and the risk of osteoporotic fractures in the elderly

Dietary fat intake and the risk of osteoporotic fractures in the elderly

Possible association of psoriasis and reduced bone mineral density due to increased TNF-α and IL-6 concentrations

The immune system and postmenopausal osteoporosis

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