Increase in endogenous thrombopoietin in healthy donors after automated plateletpheresis

Dettke, Markus; Hlousek, M.; Kurz, Martin; Leitner, Gerda; Rosskopf, Konrad; Stiegler, G; Stohlawetz, Petra; Worel, Nina; Höcker, P; Panzer, Sarah E.

doi:10.1046/j.1537-2995.1998.38598297213.x

Cited by 28 publications

(34 citation statements)

References 20 publications

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“…37 Indeed, prior studies have shown that serum thrombopoietin levels are increased after plateletpheresis procedures for platelet donation. 38,39 In turn, increased thrombopoietin levels might lead to enhanced CD34 ϩ responses because of expansion of the marrow progenitor pool. 40 It is also possible that the relative lymphopenia produced after lymphapheresis might have resulted in a positive effect on mobilization through a process similar to homeostatic recycling and peripheral expansion, which has been reported to occur for T cells in lymphopenic states.…”

Section: Discussionmentioning

confidence: 99%

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population

Vasu¹,

Leitman²,

Tisdale

et al. 2008

Blood

114

123

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Section: Discussionmentioning

confidence: 99%

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population

Vasu¹,

Leitman²,

Tisdale

et al. 2008

Blood

114

123

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“…Among females, this decrease tends to be greater [32,33]. Interestingly, the fall in platelet count does not correlate with the yield of the plateletpheresis procedure as more platelets are collected than anticipated due to the mobilization of platelets from the spleen during collection [29].…”

Section: Bleeding Thrombocytopeniamentioning

confidence: 93%

“…Interestingly, the fall in platelet count does not correlate with the yield of the plateletpheresis procedure as more platelets are collected than anticipated due to the mobilization of platelets from the spleen during collection [29]. Dettke et al found the time required for a donor to return to baseline following a platelet donation to be four days in males with a delay in increase of thrombopoietin levels and a corresponding delay in return to normal platelet counts in females [33]. In donors undergoing alternate day collections, platelet count and apheresis yields have been shown to return to baseline levels by day 10 of collection with stabile counts and yields with subsequent collections [34].…”

Section: Bleeding Thrombocytopeniamentioning

confidence: 99%

Complications of donor apheresis

Winters

2006

J. Clin. Apheresis

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A decreasing blood donor pool in the presence of increasing blood transfusion demands has resulted in the need to maximally utilize each blood donor. This has led to a trend in the increasing use of automated blood collections. While apheresis donation shares many reactions and injuries with whole blood donation, because of the differences, unique complications also exist. Overall, evidence in the literature suggests that the frequency of reactions to apheresis donation is less than that seen in whole blood donation, though the risk of reactions requiring hospitalization is substantially greater. The most common apheresis-specific reaction is hypocalcemia due to citrate anticoagulation, which, while usually mild, has the potential for severely injuring the donor. Other reactions to apheresis donation are uncommon (e.g., hypotension) or rare (e.g., air embolism). More worrisome, and in need of additional study, are the long-term effects of apheresis donation. Recent evidence suggests that repeated apheresis platelet donations may adversely effect thrombopoiesis as well as bone mineralization. Granulocyte donation has also been implicated in unexpected long-term consequences.

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“…This finding might be the result of increased serum levels of hematopoietic growth factors, which were stimulated by the number of cells removed during the leukapheresis procedure. Several publications have reported that serum levels of thrombopoietin (TPO) were significantly increased up to 7 days after plateletpheresis [19,20,21]. Furthermore, Dettke et al [19] detected a decline in serum TPO levels as PLT counts increased.…”

Section: Discussionmentioning

confidence: 99%

“…Several publications have reported that serum levels of thrombopoietin (TPO) were significantly increased up to 7 days after plateletpheresis [19,20,21]. Furthermore, Dettke et al [19] detected a decline in serum TPO levels as PLT counts increased. Weisbach et al [21], who focused on systemic levels of diverse hematopoietic growth factors, found likewise a significantly increased erythropoietin level after plateletpheresis, whereas the stem cell factor levels decreased significantly.…”

Section: Discussionmentioning

confidence: 99%

Low-Volume Leukapheresis in Non-Cytokine-Stimulated Donors for the Collection of Mononuclear Cells

Anyanwu

Sitzmann

Hetjens

et al. 2018

Transfus Med Hemother

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Background: There is an increasing demand for products containing mononuclear cells (MNCs) for cellular immune therapy. Hence, leukapheresis is increasingly performed in healthy volunteer donors. Methods: We evaluated 147 low-volume leukapheresis procedures from 77 healthy non-cytokine-stimulated donors. Complete blood counts (CBCs) of the donors were measured before and directly after the procedures as well as from the MNC products. Follow-up CBCs were collected from donors within 21 days. Results: The product hematocrit within a range from 1.2 to 6.0% did not correlate with the collection efficiency of any cell population or the granulocyte and platelet yield. There was a strong correlation between the CBC values before leukapheresis and the cell yield of lymphocytes and monocytes as well as a perfect negative correlation between cell recruitment and cell loss in all cell populations. Furthermore, we observed a significant decrease in the CBC values in all cell populations directly after leukapheresis, which recovered within a mean of 16.1 days (SD ± 2.1 days) and even showed a significant increase in granulocytes and platelets. Conclusion: Low-volume leukapheresis is feasible for the collection of MNCs in which the product hematocrit is negligible for the collection efficiency, cell yield, or contamination of residual cells under operational settings recommended by the manufacturer. Our data suggests that cell recruitment is regulated by the number of cells removed, which may also be the stimulus to induce granulo- and thrombopoiesis within the first days after leukapheresis.

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Increase in endogenous thrombopoietin in healthy donors after automated plateletpheresis

Abstract: Single-donor plateletpheresis results in a temporary increase in serum TPO levels in healthy platelet donors, which may be part of a compensatory response-boosting megakaryocytopoiesis after platelet collection.

Cited by 28 publications

References 20 publications

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population

Complications of donor apheresis

Low-Volume Leukapheresis in Non-Cytokine-Stimulated Donors for the Collection of Mononuclear Cells

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