Increase in head and neck cancer in younger patients due to human papillomavirus (HPV)

Young, David; Xiao, Christopher C.; Murphy, B. A.; Moore, Michael G.; Fakhry, Carole; Day, Terry A.

doi:10.1016/j.oraloncology.2015.03.015

Cited by 196 publications

(157 citation statements)

References 25 publications

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“…Head and neck cancer represents a steadily increasing survivor population, and by 2030, it will represent the third most common group of radiation-treated cancer survivors. The shifting epidemiology in head and neck cancer with increasing numbers of human papilloma virus-related cancers will likely alter the demographics of this survivorship population in the years to come (19,20).…”

Section: Discussionmentioning

confidence: 99%

Trends in Radiation Therapy among Cancer Survivors in the United States, 2000–2030

Bryant

Banegas

Martı́nez

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

109

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Background: Although the number of cancer survivors has increased substantially over the past several decades, the composition of survivors treated with radiotherapy is not well defined. Radiotherapy carries unique long-term toxicity risks for cancer survivors. This study describes the current estimates and future projections of the epidemiology of 5-year cancer survivors who receive radiation therapy.Methods: We used cancer incidence and survival data from the Surveillance, Epidemiology, and End-Results (SEER) database linked to U.S. Census data to estimate the number of 5-year cancer survivors treated with radiation between 2000 and 2030. Future projections assumed continuing incidence and survival trends based on historical rates.Results: In 2016, there were an estimated 3.05 million cancer survivors treated with radiation, accounting for 29% of all

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Section: Discussionmentioning

confidence: 99%

Trends in Radiation Therapy among Cancer Survivors in the United States, 2000–2030

Bryant

Banegas

Martı́nez

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

109

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“…Recently, women are reportedly at risk of this infection apart from much susceptible male in places like Vietnam [9]. Some estimates suggest that 70-90% of new oropharyngeal cancers have evidence of HPV [10]. Viral regulation of miRNA expression in oral cancer diagnosis including that of Epstein-Barr virus apart from HPV has also been stated in India [11].…”

Section: Discussionmentioning

confidence: 99%

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Pal¹,

Raychowdhury²,

Halder³

2016

Otolaryngol (Sunnyvale)

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Objective: The aim is to find out any possible correlation between HPV infection and oral carcinoma along with this metal toxicity. Methods:Ethical clearance for this study was obtained from the Ethics Committee of Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan. Patients attending our hospital were screened for the presence of oral premalignant and malignant lesions. The subjects were administered a standard questionnaire. The buccal swab and hair samples (107 cases and 50 controls) were collected after obtaining informed consent from all the corresponding subjects, and were analysed for detection of HPV 16 DNA and arsenic level analysis, respectively.Results: 22.5% of malignant samples showed the presence of HPV 16 DNA. 80% of cases showed their arsenic count above the safe limit (0.8 µg/g). Conclusion:A considerable percentage of malignant samples showed the presence of HPV16 DNA, indicating that there may be a correlation between HPV infection and oral malignancy in this population. A higher percentage of cases showing an elevated arsenic count states a possible link between arsenic toxicity and the development of this disease. However, a higher population size and statistical analysis are required for a proper conclusion.

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“…5 A infecção pelo vírus humano do papiloma é actualmente considerada um importante fator etiológico para estas neoplasias, especialmente quando localizadas na orofaringe, e quando presentes em indivíduos mais jovens. 5,6 A exposição ao pó de madeira, aos produtos utilizados na curtimenta de cabedais e ao níquel são fatores de risco conhecidos para o desenvolvimento de tumores no nariz e nos seios perinasais, 7 e a infecção pelo vírus Epstein-Barr está relacionada com os tumores localizados na nasofaringe. 8 As características epidemiológicas dos doentes portadores de tumores da cabeça e do pescoço podem variar entre países e entre regiões de um mesmo país.…”

Section: 4unclassified

Características Epidemiológicas e Demográficas dos Doentes Portadores de Tumores da Cabeça e Pescoço no Norte de Portugal: Impacto na Sobrevivência

et al. 2016

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The analyzed variables were the anatomical location of the tumor, staging, gender and age of patients, the district of origin, the alcohol and tobacco consumption, educational level, occupation, marital status and family structure. Results:The 566 patients studied (498 men and 68 women) presented a mean age of 58.1 ± 12.2 years. The majority (80.5%) were referenced in advanced stage of disease (III and IV). Seventy eight per cent of patients had moderate or excessive alcohol consumption and 69% were smokers. The vast majority of patients (82.3%) had only basic education. Patients with tumors of the hypopharynx and excessive drinking habits were referenced in more advanced stages and had a poorer survival (p < 0.001). Married patients were referred at earlier stages (p = 0.020) and patients without family support had poorer survival (p = 0.030). Discussion: Epidemiological data are in agreement with the international literature. The high rate of patients referred with advanced stage of disease can be attributed to the patient´s delay in seeking medical care or by factors inherent to the referral system. Surveillance and family support play a key role in early referral and survival of these patients. Conclusion:This study features a population profile that can benefit from a higher degree of surveillance, awareness campaigns and/ or screenings. Some of the variables can significantly influence the tumor stage and survival.

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Increase in head and neck cancer in younger patients due to human papillomavirus (HPV)

Cited by 196 publications

References 25 publications

Trends in Radiation Therapy among Cancer Survivors in the United States, 2000–2030

Trends in Radiation Therapy among Cancer Survivors in the United States, 2000–2030

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Características Epidemiológicas e Demográficas dos Doentes Portadores de Tumores da Cabeça e Pescoço no Norte de Portugal: Impacto na Sobrevivência

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