Increase in Incidental Renal Cell Carcinoma in the Northern Part of the Netherlands

Does overweight impact on the prognosis of patients with renal cell carcinoma? A single center experience of 683 patients

“…About 80% of tumors originate from renal parenchyma. The incidence has recently increased both in North America [1] and in Europe [2,3]. Many risk-factors may play a role in this increase, including nutritional [4][5][6] or hormonal [7] parameters, hypertension [8], family history of renal cell carcinoma (RCC) not related to von-Hippel-Lindau disease [9] as well as smoking or coffee drinking [8,[10][11][12].…”

Contralateral Adrenal Metastasis After Renal Cell Carcinoma Treatment

“…In approximately half of the patients, the metastatic disease was diagnosed. However, with the existence of advanced imaging technologies such as USG, CT, and magnetic resonance (MR), the ratio of coincidentally diagnosed RCC cases varies between 15% and 60% [3,4], with one-third of the patients suffering from the metastatic disease and despite sufficient treatment in one-third of the diagnoses cases metastases will occur [1]. Whereas the high grade of the primary tumor increases metastasis risk, the histopathological subtype (clear cell type mostly to the lungs, papillary to the lymph nodes, and chromophobe to the liver) provides a clue to which sites metastases will occur [5].…”

Clinical Aspects of Renal Cell Carcinoma

“…It is generally postulated that the increased incidence rates reflect earlier diagnosis at an earlier stage, largely due to more liberal use and better quality of modern radiological imaging techniques such as ultrasonography, computerized tomography (CT) and magnetic resonance imaging (MRI) [4,[7][8][9][10]. An interesting observation is that a higher proportion of women and elderly are noted within the incidentally detected cohorts [4,[11][12][13]. This can be explained, at least in part, by more frequent physician visits by females and the elderly [11].…”