Increase in Lassa Fever Cases in Nigeria, January–March 2018

Ilori, Elsie; Frank, Christina; Dan-Nwafor, Chioma; Ipadeola, Oladipupo; Krings, Amrei; Ukponu, Winifred; Womi-Eteng, Oboma E.; Adeyemo, Ayodele; Mutbam, Samuel; Musa, Emmanuel; Lasuba, Clement L.P.; Alemu, Wondimagegnehu; Okogbenin, Sylvanus; Ogbaini, Ephraim; Unigwe, Uche; Ogah, Emeka Onwe; Onoh, Robinson Chukwudi; Abejegah, Chukwuyem; Ayodeji, Oladele Oluwafemi; Ihekweazu, Chikwe

doi:10.3201/eid2505.181247

Cited by 40 publications

(49 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1,2] As compared to the only 260 known human pathogenic viruses, the unknown varieties of viruses represent 99.9% of potential zoonoses, which cannot be diagnosed until symptoms are noticed. [3] Moreover, the recent unusual worldwide outbreaks of Nigerian Lassa virus in 2018, [4] Indian Nipah virus in 2018, [5] Brazilian yellow fever in 2017, [6] West African Ebola in 2017, [7] Brazilian Zika virus in 2015 [8] and worldwide coronavirus disease 2019 (COVID-19) [9] took terrible tolls, both on human life and on the global economy.…”

Section: Introductionmentioning

confidence: 99%

Benzothiazoles as potential antiviral agents

Asiri

Alsayari

Muhsinah

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic. Key findings Benzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight into the recent development of benzothiazole-based antiviral agents, with a special focus on their structure-activity relationships and lead optimisation. One hundred and five articles were initially identified, and from these studies, 64 potential novel lead molecules and main findings were highlighted in this review. Summary We hope this review will provide a logical perspective on the importance of improving the future designs of novel broad-spectrum benzothiazolebased antiviral agents to be used against emerging viral diseases. Benzothiazoles as antiviral agents Yahya I. Asiri et al.

show abstract

Section: Introductionmentioning

confidence: 99%

Benzothiazoles as potential antiviral agents

Asiri

Alsayari

Muhsinah

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…LF is predominant in West Africa including Sierra Leone, Liberia and Nigeria (2). It affects 100,000 to 300,000 people every year in this region (3).There have been several LF outbreaks in various parts of Nigeria and the largest outbreak ever reported was in 2018 which shows an increasing trend in the number of cases and deaths (4) . In 2018, a total of 3016 suspected LF cases were reported from 22 states.…”

Section: Introductionmentioning

confidence: 99%

“…All the affected 22 states had at least one confirmed case spreading through 90 Local Government Areas (LGAs). Three of the 22 affected states constituted 83.0% of the confirmed cases: Edo (46%), Ondo (24%) and Ebonyi (13%) states (4). Edo State is one of the states in Nigeria with high burden of LF cases with occurrence all through the year.…”

Section: Introductionmentioning

confidence: 99%

Spatial analysis of confirmed Lassa fever cases in Edo State, Nigeria, 2008 – 2014

Owoicho

Awosanya

Fadugba

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Lassa fever (LF) is endemic and poses public health threats in Edo State. Identification of primary clusters will help prioritize public health interventions in the state. We investigated retrospective cases of LF to identify primary cluster of the disease for household exposure management. Method: We reviewed retrospective data (n = 1400) of LF case-patients at a referral hospital in Edo State from 2008 to 2014 based on World Health Organization case definition for LF.We determined primary cluster of confirmed cases on Bernoulli model and evaluated environmental factors in the primary cluster: presence of rodent deterrents, proximity of households at 2 km radius to rice farm, rice post-harvest storage facility, refuse dump, forest, hospital and main road using Multi-criteria analysis at p < 0.05. Results: Of the reviewed cases, 171 (12.2%) were confirmed casepatients. The median age of confirmed case-patients was 30 years (Q1:16.0 and Q3: 43.5). Of the confirmed case-patients, 101 (59.1%) were male. A primary spatial cluster (4.45 km radius; geographic centre at 6.717900oN, 6.243500oE) was identified in Esan West LGA. Associated environmental factors included presence of rodent deterrents (p < 0.001), proximities of households to refuse dump (p < 0.001), rice post-harvest storage facility (p = 0.01) and rice farm (p = 0.03). Conclusion: Esan WestLGA was identified as a primary cluster for Lassa fever. Presence of rodent deterrents, household proximity to refuse dump sites, rice storage facilities and rice farms were associated environmental factors. We recommend improved rice post-harvest storage and use of rodent deterrents in Edo State, Nigeria.

show abstract

“…LF is predominant in West Africa including Sierra Leone, Liberia and Nigeria (2). It affects 100,000 to 300,000 people every year in this region (3) There have been several LF outbreaks in various parts of Nigeria and the largest outbreak ever reported was in 2018 which shows an increasing trend in the number of cases and deaths (4). In 2018, a total of 3016 suspected LF cases were reported from 22 states.…”

Section: Introductionmentioning

confidence: 99%

“…All the affected 22 states had at least one confirmed case spreading through 90 Local Government Areas (LGAs). Three of the 22 affected states constituted 83.0% of the confirmed cases: Edo (46%), Ondo (24%) and Ebonyi (13%) states (4). This study, therefore, aimed at identifying primary spatial cluster for confirmed LF cases in Edo State, an endemic LF state, and its' associated environmental factors in the primary cluster…”

Section: Introductionmentioning

confidence: 99%

Spatial analysis of confirmed Lassa fever cases in Edo State, Nigeria, 2008 – 2014

Owoicho

Awosanya

Fadugba

et al. 2019

Preprint

View full text Add to dashboard Cite

Spatial analysis of confirmed Lassa fever cases in Edo State, Nigeria, 2008 – 2014 S. Owoicho 1 , E. Awosanya 2 , D. Fadugba 2 , M. S. Balogun 1 ,P. Nguku 1 , W. S. Ajisegiri 1 , O. Eugene 2 , B. Olugasa 2 1 Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria; 2 Centre for Control and Prevention of Zoonoses, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria . Background: Lassa fever (LF) is endemic and poses public health threats in Edo State. Identification of primary clusters will help prioritize public health interventions in the state. We investigated retrospective cases of LF to identify primary cluster of the disease for household exposure management. Method: We reviewed retrospective data (n = 1400) of LF case-patients at a referral hospital in Edo State from 2008 to 2014 based on World Health Organization case definition for LF. We determined primary cluster of confirmed cases on Bernoulli model and evaluated environmental factors in the primary cluster: presence of rodent deterrents, proximity of households at 2 km radius to rice farm, rice post-harvest storage facility, refuse dump, forest, hospital and main road using Multi-criteria analysis at p < 0.05. Results : Of the reviewed cases, 171 (12.2%) were confirmed case-patients. The median age of confirmed case-patients was 30 years (IQR: 27.5). Of the confirmed case-patients, 101 (59.1%) were male. A primary spatial cluster (4.45 km radius; geographic centre at 6.717900 o N, 6.243500 o E) was identified in Esan West LGA. Associated environmental factors included presence of rodent deterrents (p < 0.001), proximities of households to refuse dump (p < 0.001), rice post-harvest storage facility (p = 0.01) and rice farm (p = 0.03). Conclusion : Esan West LGA was identified as a primary cluster for Lassa fever. Presence of rodent deterrents, household proximity to refuse dump sites, rice storage facilities and rice farms were associated environmental factors. We recommend improved rice post-harvest storage and use of rodent deterrents in Edo State, Nigeria.

show abstract

Increase in Lassa Fever Cases in Nigeria, January–March 2018

Cited by 40 publications

References 1 publication

Benzothiazoles as potential antiviral agents

Benzothiazoles as potential antiviral agents

Spatial analysis of confirmed Lassa fever cases in Edo State, Nigeria, 2008 – 2014

Spatial analysis of confirmed Lassa fever cases in Edo State, Nigeria, 2008 – 2014

Contact Info

Product

Resources

About