1997
DOI: 10.1152/ajpregu.1997.273.4.r1557
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Increase in muscle IGF-I protein but not IGF-I mRNA after 5 days of endurance training in young rats

Abstract: Five days of treadmill training in rats leads to increased muscle size and running time. This was used to examine the effect of exercise on circulating insulin-like growth factor I [IGF-I; radioimmunoassay (RIA)], local muscle (hindlimb) IGF-I (by RIA), and muscle IGF-I mRNA (by ribonuclease protection assay). Eight-week-old female Sprague-Dawley rats were divided into three groups: control ( n = 10); single-exercise test ( n = 10), untrained but with one maximal exercise test at the end of the study; and trai… Show more

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Cited by 54 publications
(47 citation statements)
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“…Similar increases in protein synthesis in the absence of a concomitant increase in mRNA synthesis have been previously described for ferritin and insulin-like growth factor-1. 61,62 Hb released from ruptured erythrocytes is a molecule with toxic and proinflammatory properties and consequently requires immediate clearance from the circulation and areas of tissue damage. 63 In the present study, the strong expression of CD163 on macrophages and microglia in encephalitic brain may enable these phagocytic cells to clear Hb/Hp complexes and in doing so perform an anti-inflammatory role.…”
Section: Discussionmentioning
confidence: 99%
“…Similar increases in protein synthesis in the absence of a concomitant increase in mRNA synthesis have been previously described for ferritin and insulin-like growth factor-1. 61,62 Hb released from ruptured erythrocytes is a molecule with toxic and proinflammatory properties and consequently requires immediate clearance from the circulation and areas of tissue damage. 63 In the present study, the strong expression of CD163 on macrophages and microglia in encephalitic brain may enable these phagocytic cells to clear Hb/Hp complexes and in doing so perform an anti-inflammatory role.…”
Section: Discussionmentioning
confidence: 99%
“…In endurance training studies, IGFBP-3 has been shown to be independent of IGF-I responses and potentially to have its own biological activity at the level of the cell (Jones and Clemmons 1995). Eliakim et al (Eliakim et al 1997) showed that in rat, muscle IGF-I concentrations can increase with relatively shortduration endurance training, despite lack of change in muscle IGF-I mRNA or serum IGF-I. These authors proposed that the mechanisms through which muscle IGF-I concentrations post-training could alter with no concurrent changes in muscle IGF-I mRNA nor indeed serum IGF-I levels may either involve (a) translational and/or post-translational-mediated events, (b) exerciseinduced increase in total blood volume or (c) modulated characteristics of the IGF binding proteins in the muscle tissue.…”
Section: Molecular Background Of the Observed In Vivo Muscle Charactementioning
confidence: 99%
“…Exercise training as a natural form of stretch exposure has similar effects on skeletal muscle IGF-1 expression. In a model of treadmill exercise in young rats, Eliakim et al [133] described a significant increase in skeletal muscle IGF-1 protein levels after 6 days with no change in systemic IGF-1 serum concentrations. Similarly, a greater than a two times increase in local IGF-1 expression after 6 months of exercise training was found in patients with stable CHF [134,135].…”
Section: Igf-1 and Exercisementioning
confidence: 99%