Increase in plasma thrombomodulin in systemic lupus erythematosus with antiphospholipid antibodies

Karmochkine, Marina; Cacoub, P.; Aillaud, M F; Juhan, I; Harlé, Jean‐Robert; Piette, Jean‐Charles; Boffa, MC

doi:10.1016/0049-3848(92)90552-l

Cited by 9 publications

(12 citation statements)

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“…Increased sTM levels have recently been demonstrated in patients with thrombotic thrombocytopenic purpura and in a selected group of SLE patients with antiphospholipid antibody syndrome (13)(14)(15). In our investigations of unselected SLE patients in all stages of disease, we found a very close correlation between sTM levels and clinical activity of disease.…”

Section: Discussionsupporting

confidence: 63%

Serum thrombomodulin

Boehme

Nawroth

Kling

et al. 1994

Arthritis & Rheumatism

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Objective. Soluble thrombomodulin (sTM), a proposed serum marker of endothelial cell injury, was investigated as a parameter of disease activity in patients with systemic lupus erythematosus (SLE).Methods. Levels of sTM were determined by enzyme-linked immunosorbent assay. Disease activity was assessed using 3 established scoring systems: the American College of Rheumatology (ACR), the New York Hospital for Special Surgery (NYHSS), and the Systemic Lupus Activity Measure (SLAM) systems.Results. A close correlation was found between sTM levels and disease activity as assessed with all 3 scoring systems: r = 0.52 by the ACR, 0.75 by the NYHSS, and 0.82 by the SLAM.Conclusion. We found that sTM is a sensitive serologic marker of organ involvement in patients with SLE. Furthermore, sTM may prove to be an important marker for vasculitis in general.Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology which is

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Section: Discussionsupporting

confidence: 63%

Serum thrombomodulin

Boehme

Nawroth

Kling

et al. 1994

Arthritis & Rheumatism

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“…In SLE, TM appeared to be associated with vasculitis, nephritis and central nervous system (CNS) lupus [8]. However, there was controversial data from previous small studies whether TM was associated with antiphospholipid antibodies and laboratory markers of in¯ammatory activity such as complement consumption, anti-dsDNA antibodies or lymphocytopenia [8,9,21,22].…”

Section: Discussionmentioning

confidence: 99%

Thrombomodulin in systemic lupus erythematosus: association with clinical and laboratory parameters

Witte

Hartung

Sachse³

et al. 1999

Rheumatology International

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Thrombomodulin is an endothelial cell membrane glycoprotein and is detected in plasma and serum after endothelial injury. In our study comprising 311 patients with systemic lupus erythematosus (SLE) clinical and laboratory associations of elevated thrombomodulin serum concentrations were examined. Elevated thrombomodulin concentrations were detected in 7.1% of the SLE patients and were associated with nephritis including the laboratory parameters proteinuria and erythrocyte casts, vasculitis and neurological involvement of the central nervous system. These correlations remained significant after consideration of the influence of renal function. In SLE, the serum thrombomodulin concentration may become a marker to monitor damage of endothelial cells and involvement of the central nervous system.

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“…,thrombomodulin Ag has been shown to be a marker of endothelial damage in vitro [22] and previous clinical studies have shown that plasma levels of ,thrombomodulin Ag are increased in various diseases associated with endothelial cell damage or proteolytic activity on the endothelial cell surface (DIC [23,24], adult respiratory distress syndrome (ARDS) [24], thromboembolic disease [23,24], thrombotic thrombocytopenic purpura [25,26], diabetes mellitus with microangiopathy [23,27], systemic lupus erythematosus (SLE) [28], and chronic myelogenous leukemia [29]). …”

Section: Discussionmentioning

confidence: 99%

Thrombomodulin: A marker for endothelial damage during orthotopic liver transplantation

Himmelreich¹,

Riewald²,

Rosch³

et al. 1994

American J Hematol

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Thrombomodulin is a surface protein of vascular endothelial cells. A smaller form of thrombomodulin in blood and urine, the soluble (s)thrombomodulin, appears to be derived from injured endothelial cells or to be proteolytically cleaved from thrombomodulin by proteases. Several in vitro and in vivo studies have suggested (s)thrombomodulin as a marker of endothelial damage. In orthotopic liver transplantation, platelet and leukocyte activation as well as prothrombin activation are suspected of being caused by damaged endothelial cells in the graft liver. We determined (s)thrombomodulin antigen as well as thrombin-antithrombin III complexes, protein C, and antithrombin III activities in the course of 23 orthotopic liver transplantations. Samples were taken at 7 different time-points intraoperatively, as well as out of the perfusate released from the graft liver vein during the flushing procedure with arterial blood prior to the opening of the hepatocaval anastomosis. Levels of (s)thrombomodulin antigen and thrombin-antithrombin III complexes showed a significant increase with reperfusion of the graft liver and levels in the perfusate were higher (both: P = 0.0001) than the corresponding systemic levels. In parallel, antithrombin III decreased significantly with reperfusion and perfusate levels of antithrombin III and protein C activities were lower in the systemic circulation (both: P = 0.0001). In conclusion, high levels of (s)thrombomodulin antigen in the early reperfusion phase and in the perfusate strongly indicate endothelial damage to the graft liver vascular bed, paralleled and followed by signs of prothrombin activation.

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Increase in plasma thrombomodulin in systemic lupus erythematosus with antiphospholipid antibodies

Cited by 9 publications

References 0 publications

Serum thrombomodulin

Serum thrombomodulin

Thrombomodulin in systemic lupus erythematosus: association with clinical and laboratory parameters

Thrombomodulin: A marker for endothelial damage during orthotopic liver transplantation

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