1982
DOI: 10.1530/acta.0.0990018
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Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man

Abstract: Abstract. Arginine aspartate was administered orally (250 mg/kg/day) for one week to 5 healthy male human volunteers aged 20–35. After this period, the 24 h patterns of growth hormone (GH) and prolactin (Prl) secretion were determined by radioimmunoassay on blood samples withdrawn every 20 min and correlated with the polygraphic recordings of electroencephalogram, electromyogram and electrooculogram. The results were compared to data obtained in identical conditions with the same subjects but after a week of p… Show more

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Cited by 40 publications
(12 citation statements)
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“…In our study, we did not find any changes in endocrine parameters with l-arginine therapy, which might have altered arterial physiology. Other investigators, however, have demonstrated that oral l-arginine may enhance insulin and prolactin secretion (39)(40)(41), and may influence the immune system, altering plasma interleukin and T lymphocyte responses (42,43). It is uncertain if any or all of these changes might contribute to the beneficial effects of oral l-arginine on vascular physiology in hypercholesterolemic subjects.…”
Section: Discussionmentioning
confidence: 99%
“…In our study, we did not find any changes in endocrine parameters with l-arginine therapy, which might have altered arterial physiology. Other investigators, however, have demonstrated that oral l-arginine may enhance insulin and prolactin secretion (39)(40)(41), and may influence the immune system, altering plasma interleukin and T lymphocyte responses (42,43). It is uncertain if any or all of these changes might contribute to the beneficial effects of oral l-arginine on vascular physiology in hypercholesterolemic subjects.…”
Section: Discussionmentioning
confidence: 99%
“…Arginine has shown some promise in relation to GH release,44 with evidence for GH stimulation in human subjects known for many years 18. Orally administered arginine aspartate (250 mg · kg −1 · day −1 ) for one week in healthy men, increased the slow wave sleep related GH secretion by at least 24% in a sample of five subjects 45. A combination of acetyl-L-carnitine and L-ornithine have been hypothesized to stimulate GH, noted in a case-study report;46 however, we are unaware of clinically controlled investigations with regards to these agents, either individually or in combination.…”
Section: Discussionmentioning
confidence: 99%
“…[12] did not find any increase in GH secretion after a 15‐day administration of the low dose of 3 g of arginine per day in older subjects. On the contrary, a 1‐week oral administration of 250 mg/kg/day arginine, corresponding to approximately half the dose we used, has been shown to increase GH concentration [13]. The single oral administration of 8 or 10 g arginine increased GH secretion in response to GHRH in aged subjects [14].…”
Section: Discussionmentioning
confidence: 99%