Increase in superoxide dismutase after cerebrovascular accident

Gruener, Nachman; Gross, Bella; Gozlan, Orly; Barak, Moshe

doi:10.1016/0024-3205(94)90159-7

Cited by 36 publications

(24 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In keeping with previous studies by Gruener et al 35 and Adachi et al, 36 we did not find a significant difference between SOD plasma levels of patients and those of controls. On the other hand, Spranger et al 37 observed significant reduction in SOD activity within 5 days after a stroke, which reverted to control levels later on.…”

Section: Discussionsupporting

confidence: 80%

Oxidative Stress in the Context of Acute Cerebrovascular Stroke

Kossi

Zakhary

2000

Stroke

156

View full text Add to dashboard Cite

Background and Purpose-Free radical generation and consequent oxidative stress in thrombotic cerebrovascular stroke have a distinctive role in the pathogenesis of ischemic brain injury. One of the potential injurious effects of homocyst(e)ine in occlusive vascular diseases is free radical generation. In the current study, we investigated the status of oxidant stress in the acute phase of thrombotic cerebrovascular stroke and the possible role of homocyst(e)ine. Methods-We determined levels of plasma homocyst(e)ine, lipid peroxide, ascorbic acid, superoxide dismutase, and nitric oxide in 30 patients with thrombotic cerebrovascular stroke within 2 days of the onset of the attack as well as in 22 healthy volunteers of comparable age and gender. Results-Statistically significant elevation of homocyst(e)ine (PϽ0.001), lipid peroxide (PϽ0.001), and nitric oxide (PϽ0.001) plasma levels were observed in stroke patients compared with healthy controls. On the other hand, the antioxidant ascorbic acid plasma levels were significantly lower in the patient group compared with healthy control subjects (PϽ0.001). Meanwhile, superoxide dismutase plasma levels were not statistically different in either groups.The study also revealed a significant and strong positive correlation between homocyst(e)ine and lipid peroxide (rϭ0.85, PϽ0.001). Ascorbic acid plasma levels were significantly negatively correlated with both homocyst(e)ine (rϭϪ0.875, PϽ0.001) and lipid peroxide (rϭϪ0.576, PϽ0.001). The nitric oxide level was positively correlated with superoxide dismutase (rϭ0.396, PϽ0.05). Conclusions-We conclude that hyperhomocyst(e)inemia is a possible causal factor in free radical generation during the acute phase of thrombotic cerebrovascular stroke. Pharmacological intervention could potentially be beneficial in this setting and warrants further evaluation.

show abstract

Section: Discussionsupporting

confidence: 80%

Oxidative Stress in the Context of Acute Cerebrovascular Stroke

Kossi

Zakhary

2000

Stroke

156

View full text Add to dashboard Cite

show abstract

“…Stevens, Jakobs, de Jager, Cunningham, and Korf (1999) observed that in 19 patients with acute cerebral embolism, serum NSE levels increased within 4 hr of the attack. Gruener, Gross, Gozlan, and Barak (1994) found that NSE levels in blood and CSF of patients with acute stroke reached peak values after 7 days. Increased levels of NSE have also been reported in a variety of other neurological disorders including Guillain‐Barré syndrome and cerebral trauma as well as specific neuroendocrine tumors (Isgrò et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory factors related to acute isolated vertigo or dizziness and cerebral infarction

et al. 2018

View full text Add to dashboard Cite

ObjectiveTo clarify the relationship of clinical factors with isolated vertigo or dizziness of cerebrovascular origin.MethodsClinical data of patients admitted in East Hospital from Jan. 2015 to Apr. 2016, whose complaint were acute vertigo or dizziness were retrospectively collected. All patients arrived at the emergency department within 24 hr of symptom onset, had no acute ischemic lesion first CT and NIHSS score of 0. Patients were divided into cerebral infarction group and noncerebral infarction group according to subsequent cerebral imaging results and clinical and laboratory factors related to cerebral infarction were analyzed.Result51.6% of patients were female (n = 141). 46 patients (16.8%) were diagnosed with acute cerebral infarction. Baseline demographic data of the two groups was not significantly different. Univariate analysis found that history of smoking (p = 0.009), headache (p = 0.028), unsteadiness (p = 0.009), neuron specific enolase (p = 0.001), and vertebral artery abnormalities found on imaging (p = 0.009) were the significant difference between two groups. Increased neuron specific enolase (p = 0.005) and an abnormal vertebral artery (p = 0.044) were significant on multivariate analysis.Conclusions16.8% of acute isolated vertigo or dizziness presentations were diagnosed with acute cerebral infarction. Increased serum neuron specific enolase and vertebral artery abnormalities were the strongest indicators of acute cerebral infarction.

show abstract

“…Some studies observed an augmentation of SOD concentration in plasma (Gruener et al, 1994) or CSF (Strand, & Marklund, 1992). Strand and Marklund (1992) reported good correlation between the increased Cu,Zn-SOD activity in CSF with the size of the infarct and functional impairment.…”

Section: A S T O E N D O G E N O U S S O D L E V E L O R a C T I V I mentioning

confidence: 99%