Increase in the levels of chaperone proteins by exposure to β-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor α cDNA

Kita, K; Jin, Yuan-Hu; Sun, Zhuo; Chen, Shiping; Sumiya, Y U; Hongo, Tetsuro; Suzuki, Nobuo

doi:10.1016/j.tiv.2009.02.011

Cited by 19 publications

(7 citation statements)

References 44 publications

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“…Studies regarding BPA have focused on hormone-like activity (38). BPA concentrations >0.01 mmol/L was noted to have an estrogen-like effect by Kita et al (39). Studies regarding cytotoxic doses of other monomers released from composite resins have shown that the toxic doses of UDMA, BISGMA, and TEGDMA on human oral mucosa membrane cells were 0.27 mmol/L, 0.11 mmol/L, and 3.7 mmol/L, respectively (32).…”

Section: Discussionmentioning

confidence: 99%

Monomer release from nanohybrid composites after bleaching

et al. 2019

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The evaluation of the effect of bleaching on monomer release from two composite resins was performed by bleaching two nanohybrid composite resins Filtek Z550 and Tetric N-Ceram using two bleaching products Whiteness HP Maxx and Vivastyle. In total, 20 samples were made from each composite resin from which four groups were fabricated (two for each bleaching product). The samples were stored in a 75% ethanol solution, and the solutions were renewed after 1, 7, and 28 days. The monomer release was analyzed using high performance liquid chromatography. The data were analyzed using repeated measures analysis of variance and least significant difference multiple comparison test (α = 0.05). Monomers were found to be released from both composite resins. The amounts of monomer released were found to decrease over time (P < 0.05); however, the resins were not affected by bleaching, and the released monomers were well below toxic doses.

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Section: Discussionmentioning

confidence: 99%

Monomer release from nanohybrid composites after bleaching

et al. 2019

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“…A dramatic upregulation of GRP78 by E 2 has been observed in the uteri of ovariectomized mice in vivo and in uterine stromal murine cells in vitro, via an estrogen receptor (ESR) independent mechanism [ 34 , 35 , 36 ]. Upregulation of HSPs, including GRP78 by estrogen and estrogenic chemicals, such as Bisphenol A (BPA), has also been described in mouse uteri and fibroblast cells in an estrogen receptor-dependent way [ 37 , 38 , 39 ]. The modulation of GRP78 upon E 2 stimulation must be related to the complex functions of endometrial cells and the spatiotemporal physiological changes that are required during the estrous cycle and embryo implantation.…”

Section: The Role Of Sex Steroids On Grp78 Expression and Functionmentioning

confidence: 99%

The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System

Hebert-Schuster

Rotta

Kirkpatrick

et al. 2018

IJMS

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The glucose-regulated protein 78 (GRP78) is a molecular chaperone that is responsible for protein folding, which belongs to the heat shock protein 70 kDa (HSPA/HSP70). Because of the conjunction of GRP78 transcription with endoplasmic reticulum stress, the chaperone plays an important role in the unfolded protein response (UPR), which is induced after the accumulation of misfolded proteins. In the last years, a significant body of research concentrated on interplay between GRP78 and sexual steroid hormones. Throughout this review, we describe the mechanisms by which GRP78 regulates steroidogenesis at multiple levels and how steroids modulate GRP78 expression in different mammalian reproductive organs. Finally, we discuss the cooperation between GRP78 and steroids for cell survival and proliferation in the context of reproduction and tumorigenesis. This new paradigm offers significant opportunities for future exploration.

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“…In an ex vivo uterine contraction study using rat uterine tissue, the presence of prostaglandin F2ɑ or oxytocin in spite of BPA exposure restores the force of contraction in a dose-dependent manner [ 103 ]. Purportedly, GPR30 activation may also be involved through an increase in oxytocin responsiveness and promotion of actin polymerization through hsp27 and MAPK phosphorylation [ 107 , 108 ]. Genes related to smooth muscle contractility and MAPK signaling have been also found to be upregulated in the presence of uterotonins in an ER-independent manner, although the exact molecular switch remains to be discovered [ 109 , 110 ].…”

Section: Resultsmentioning

confidence: 99%

Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth

Vidal

Menon

et al. 2022

IJMS

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Preterm birth remains to be one of the most prevalent obstetric complications worldwide. Since there are multiple etiological factors associated with this disease process, an integrative literature search in PubMed and Scopus databases on possible mechanism of action and effect of bisphenols on exposure on human or animal placental samples in preterm birth was conducted. From 2332 articles on initial literature search, 63 studies were included for full data extraction. Altogether, several pathways were shown to be possibly affected by bisphenols, leading to dysregulations in structural and endocrine foundation in the placenta, potential induction of senescence and failure of decidualization in the decidua, and possible propagation of inflammation in the fetal membranes. Combined, these actions may eventually counteract bisphenol-induced relaxation of the myometrium and promote contractility alongside fetal membrane weakening. In totality, these individual impairments in gestation-critical processes may lead to failure of maintenance of pregnancy, and thus effecting preterm birth.

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Increase in the levels of chaperone proteins by exposure to β-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor α cDNA

Cited by 19 publications

References 44 publications

Monomer release from nanohybrid composites after bleaching

Monomer release from nanohybrid composites after bleaching

The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System

Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth

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