Increase of circulating BDNF levels and its relation to improvement of physical fitness following 12 weeks of combined exercise in chronic patients with schizophrenia: A pilot study

Kim, Hee-jae; Song, Bong-kil; So, Byunghun; Lee, On; Song, Wook; Kim, Yeonsoo

doi:10.1016/j.psychres.2014.09.020

Cited by 63 publications

(58 citation statements)

References 34 publications

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“…Also, the increased risk of physical illnesses in patients with mental disorders [6] underlines the great importance of improvements of physical performance in schizophrenia. The finding of increased endurance capacity in patients with schizophrenia after endurance training is in agreement with other studies [21,24,[37][38][39][40][41][42][43][44] though in some studies, the methods are poorly described and the quality of the results cannot be judged properly. Still, to our knowledge no study to date has demonstrated these improvements with the set of outcome parameters used in this study.…”

Section: Discussionsupporting

confidence: 90%

Endurance training in patients with schizophrenia and healthy controls: differences and similarities

Keller-Varady

Hasan

Schneider‐Axmann

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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The aims were to examine the feasibility of and adaptations to endurance training in persons diagnosed with schizophrenia and to address the question whether the principles and beneficial effects of endurance training established in the healthy population apply also to patients with schizophrenia. In this controlled interventional study, 22 patients with schizophrenia and 22 healthy controls performed a standardized aerobic endurance training on bicycle ergometers over 12 weeks. Another group of 21 patients with schizophrenia played table soccer. Endurance capacity was measured with incremental cycle ergometry before and after the intervention and 3 months later. A specific set of outcome parameters was defined. The training stimuli can be assumed to be similar in both endurance groups. Endurance capacity improved significantly in the endurance groups, but not in the table soccer group. Patients and healthy controls showed comparable adaptations to endurance training, as assessed by physical working capacity and maximal achieved power. Differences were found in changes of performance at a lactate concentration of 3 mmol/l. Endurance training was feasible and effective in both groups. The principles and types of training that are usually applied to healthy controls need to be verified in patients with schizophrenia. Nevertheless, patients benefited from endurance training in terms of improvement of endurance capacity and reduction in the baseline deficit in comparison with healthy controls. Therefore, endurance training should be implemented in future therapy programs. These programs need to pay special attention to the differences between patients with schizophrenia and healthy controls.

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Section: Discussionsupporting

confidence: 90%

Endurance training in patients with schizophrenia and healthy controls: differences and similarities

Keller-Varady

Hasan

Schneider‐Axmann

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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show abstract

“…A number of animal studies have shown exercise-dependent changes in BDNF in the brain and upregulation of central BDNF expression in response to activity (Neeper et al, 1995, 1996; Liu et al, 2009; Hopkins et al, 2011; Marlatt et al, 2012; Hong et al, 2015). In humans, physical activity has been shown to increase circulating levels of BDNF—a proxy for central expression (Knaepen et al, 2010; Zoladz and Pilc, 2010; Kim et al, 2014; Leckie et al, 2014). Neurotrophins such as BDNF may promote cognitive benefits in several different ways, including by neural survival (Baydyuk and Xu, 2014) and improved synaptic plasticity (Leal et al, 2014), and also through the stimulation of neurogenesis (i.e., the formation of new neurons) and related changes in brain structure (Binder and Scharfman, 2004).…”

Section: From Activity To Better Cognitive Function: Potential Mechanmentioning

confidence: 99%

A Bidirectional Relationship between Executive Function and Health Behavior: Evidence, Implications, and Future Directions

2016

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Physically active lifestyles and other health-enhancing behaviors play an important role in preserving executive function into old age. Conversely, emerging research suggests that executive functions facilitate participation in a broad range of healthy behaviors including physical activity and reduced fatty food, tobacco, and alcohol consumption. They do this by supporting the volition, planning, performance monitoring, and inhibition necessary to enact intentions and override urges to engage in health damaging behavior. Here, we focus firstly on evidence suggesting that health-enhancing behaviors can induce improvements in executive function. We then switch our focus to findings linking executive function to the consistent performance of health-promoting behaviors and the avoidance of health risk behaviors. We suggest that executive function, health behavior, and disease processes are interdependent. In particular, we argue that a positive feedback loop may exist whereby health behavior-induced changes in executive function foster subsequent health-enhancing behaviors, which in turn help sustain efficient executive functions and good health. We conclude by outlining the implications of this reciprocal relationship for intervention strategies, the design of research studies, and the study of healthy aging.

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“…Studies have demonstrated the efficacy of aerobic exercise in treating the cognitive and biochemical deficits found in SCH patients (Archer and Kostrzewa, 2015). In addition to enhanced expression of insulin-like growth factor (IGF)-1 and BDNF (Kim et al, 2014;Kuo et al, 2013), people suffering from SCH who led an active lifestyle had lower levels of serum CRP when compared to the sedentary control population (Stubbs et al, 2015). It has been proposed that the overproduction of pro-inflammatory cytokines inhibits the release of BDNF (Calabrese et al, 2014), since intraperitoneal injection of IL-1β resulted in a reduction in BDNF gene expression in the hippocampus of rodents (Lapchak et al, 1993).…”

Section: Anti-inflammatory Effects Of Physical Activity and Exercise mentioning

confidence: 99%

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman

Little

Klegeris

2016

Brain Research Bulletin

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Increase of circulating BDNF levels and its relation to improvement of physical fitness following 12 weeks of combined exercise in chronic patients with schizophrenia: A pilot study

Cited by 63 publications

References 34 publications

Endurance training in patients with schizophrenia and healthy controls: differences and similarities

Endurance training in patients with schizophrenia and healthy controls: differences and similarities

A Bidirectional Relationship between Executive Function and Health Behavior: Evidence, Implications, and Future Directions

Physical activity and exercise attenuate neuroinflammation in neurological diseases

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