Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula‐fed preterm infants

Knol, Jan; Boehm, Günther; Lidestri, M; Negretti, F; Jelínek, J; Agosti, Massimo; Stahl, Bernd; Marini, Antonio; Mosca, Fabio

doi:10.1111/j.1651-2227.2005.tb02152.x

Cited by 68 publications

(55 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most notable dietrelated differences in bacterial assemblages were the greater intensities for the T-RF 233 and 583-bp bands in the distal SI of the FORM pigs. The T-RF 233-bp band corresponds with Clostridium perfringens, which has been implicated as a causative agent of NEC (19), and the greater band intensity is consistent with the higher clostridial densities associated with formula feeding (25). The 583-bp band includes several Streptococcus species, with some considered as potential pathogens (38), whereas others have probiotic properties (9).…”

Section: Discussionmentioning

confidence: 95%

Elective cesarean delivery affects gut maturation and delays microbial colonization but does not increase necrotizing enterocolitis in preterm pigs

Siggers¹,

Thymann²,

Jensen³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 95%

Elective cesarean delivery affects gut maturation and delays microbial colonization but does not increase necrotizing enterocolitis in preterm pigs

Siggers¹,

Thymann²,

Jensen³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Preliminar y studies show increased Bifidobacterium stool colonization and decreased pathogenic bacterial colonization in preterm infants fed with formula containing prebiotics (90% short chain galacto-oligosaccharide, 10% long chain fructo-oligosaccharide) compared with infants fed control formula [167] . Furthermore, prebiotic treatment may have a positive effect on host immune function [168] .…”

Section: Prebioticsmentioning

confidence: 99%

Necrotizing enterocolitis: A multifactorial disease with no cure

Schnabl

Aerde²,

Thomson³

et al. 2008

WJG

163

120

View full text Add to dashboard Cite

INTRODUCTIONNecrotizing enterocolitis (NEC) is an inflammatory bowel disease of neonates and remains one of the most common gastrointestinal emergencies in newborn infants [1] . Onset of NEC is often within the first three months of life and neonates who are of extremely low birth weight (< 1000 g) and under 28 wk gestation are the most susceptible [2] . Full term neonates account for 10% of all NEC cases while premature infants account for 90% [3] . With an incidence rate of 1%-5% for all newborns admitted to the NICU [1] , a prevalence of 7%-14% of very low birth weight infants (VLBW, 500-1500 g) [4] and a mortality rate approaching 20%-50% [5] , NEC continues to represent a significant clinical problem. In Canada, the incidence rate is 1.8 per 100 live births with a prevalence of 7% of VLBW infants [1] . Advances in obstetric and neonatal care have improved survival rates for smaller, more immature infants, and as more VLBW preterm infants survive the neonatal period, the population at risk for NEC increases [1] .No consistent association between sex, race, and rates of NEC has been identified. However, male VLBW infants and black infants are at greater risk of death [6] . Due to inadequate treatments and no effective preventative strategy, an estimated 20%-40% of babies with NEC require surgery [1] and 10%-30% experience significant morbidity including neurodevelopmental impairment, vision and hearing impairment, failure to thrive, feeding abnormalities, diarrhea, bowel obstruction, and short bowel syndrome [1,2,7] . The case fatality rate with surgical intervention is as high as 50% [1] . NEC is also a financial burden to the health care system with yearly hospital charges reported to be as high as $6.5 million in the US [8] . Thus, NEC continues to be an important health issue for preterm neonates. DIAGNOSIS Clinical signs and symptomsThe onset of NEC can occur suddenly within a few AbstractNecrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature of the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events, formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear. Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Development of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics.

show abstract

“…Some studies have reported that the addition of prebiotics to the diet results in increased levels of bifidobacteria and lactobacilli in the intestinal flora (30,31). The effects of prebiotics, including inulin, have been extensively investigated in infant nutrition studies; stool properties of infants receiving prebiotics are similar to those of breastfed infants (32).…”

Section: Placebo Groupmentioning

confidence: 99%

The role of Bifidobacterium lactis B94 plus inulin in the treatment of acute infectious diarrhea in children

İşlek

Sayar²,

Yılmaz³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: In contrast to many other studies of probiotic species, the number of publications evaluating Bifidobacterium lactis and its combinations with prebiotics as treatments for acute infectious diarrhea is limited. We investigated the synbiotic effects of B. lactis B94 plus inulin on acute infectious diarrhea. Materials and Methods: The study was conducted on children with acute diarrhea between the ages of 2 and 60 months. The patients were administered 5×10 10 colony-forming units (CFU) of B. lactis B94 plus 900 mg inulin or placebo, once a day for five days. Stools were examined for Rotavirus, Adenovirus, Entamoeba histolytica, Salmonella, Shigella, Campylobacter, Clostridium difficile, Cryptosporidium, and parasites. Results: We examined 79 patients in the synbiotic group and 77 patients in the placebo group. The duration of diarrhea was significantly reduced in the synbiotic group in comparison with the placebo group (3.9±1.2 days vs. 5.2±1.3 days, respectively; p<0.001). Moreover, the number of diarrheal stools on the third day was significantly lower in the synbiotic group than in the placebo group (5.5±2.9 vs. 8.3±3.01, respectively; p<0.001). Diarrhea in the synbiotic-group patients with rotavirus infection was of a significantly shorter duration (3.2±1.3 days vs. 5.2±1.3 days, respectively; p=0.001). Duration of diarrhea in patients who started the synbiotic treatment within the first 24 h was shorter than that in the patients who started the treatment later (3.9±1.1 days vs. 4.8±1.8 days, respectively; p=0.002). Conclusion: Treatment with 5 × 10 10 CFU of B. lactis B94 plus 900 mg inulin shortened the duration of acute watery diarrhea by an average of 31 h. This decrease was most pronounced in cases of Rotavirus diarrhea.

show abstract

Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula‐fed preterm infants

Cited by 68 publications

References 3 publications

Elective cesarean delivery affects gut maturation and delays microbial colonization but does not increase necrotizing enterocolitis in preterm pigs

Elective cesarean delivery affects gut maturation and delays microbial colonization but does not increase necrotizing enterocolitis in preterm pigs

Necrotizing enterocolitis: A multifactorial disease with no cure

The role of Bifidobacterium lactis B94 plus inulin in the treatment of acute infectious diarrhea in children

Contact Info

Product

Resources

About