Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte

Naruse, Katsuhiko; Yamasaki, Yui; Tsunemi, Taihei; Onogi, Akira; Noguchi, Taketoshi; Sado, Toshiyuki; Oi, Hidekazu; Kobayashi, Hiroshi

doi:10.1016/j.preghy.2011.07.004

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Serum leptin was significantly increased only in PIH patients compared to that in normal pregnant subjects. These trends in HMW adiponectin, leptin, and MCP-1 are similar to those in our former report that included subjects with BMIs greater than 25 kg/m 2 [17]; however, the trends in total adiponectin and HMW-to-total adiponectin ratio differ from those in our previous report.…”

Section: Resultssupporting

confidence: 88%

“…We recently reported that increased brain-type natriuretic peptide (BNP) correlated with increased adiponectin in PIH [17], similar to the findings in acute coronary syndrome [20] and cardiomyopathy [21]. We also showed that BNP induced the release of adiponectin from cultured adipocytes in vitro [17]. In this respect, further research is needed to reveal the conditions of adipose tissue in PIH patients without obesity.…”

Section: Discussionmentioning

confidence: 66%

“…It is now well accepted that the insulin-resistant state induces the mitogen-activated protein kinase pathway and increases MCP-1 secretion from adipocytes [11, 12], indicating that MCP-1 potentiates the pathology of insulin resistance. Increased MCP-1 was observed in pregnant women with severe obesity [22, 23] and preeclampsia [17, 24]. Additionally, MCP-1 secretion was reported from the human early invasive trophoblast [25].…”

Section: Discussionmentioning

confidence: 99%

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Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation

Naruse

Noguchi²,

Sado³

et al. 2012

Mediators of Inflammation

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Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy. To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; corrected with albumin to estimate unbound FFA), monocyte chemoattractant protein (MCP)-1, and high-molecular weight (HMW) adiponectin were measured in severe PIH patients with a BMI less than 25 kg/m2 and were measured 3 times during the course of pregnancy in women with normal pregnancies. FFA/albumin, MCP-1, and HMW adiponectin concentrations were significantly higher in PIH patients than in women with normal pregnancies. The 3 measurements of FFA/albumin showed a significant increase through the course of uncomplicated pregnancies. In contrast, MCP-1 and HMW adiponectin were significantly decreased during the course of pregnancy. These results suggest that the reduced MCP-1 concentration in normal pregnancy may be a pathway to inhibit the induction of pathological features from physiological insulin resistance and homeostatic inflammation.

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Section: Resultssupporting

confidence: 88%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation

Naruse

Noguchi²,

Sado³

et al. 2012

Mediators of Inflammation

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“…Emerging evidence has revealed the regulatory effects of cardiokines on adipokine synthesis and secretion. NPs increase the synthesis and secretion of adipokines in adipocytes [ 80 , 81 ], indicating metabolic potency of cardiokines in adipose tissue. Both ANP and BNP enhanced the expression of adiponectin transcripts and it secretion in dose-dependent manners [ 82 ], and the high molecular-weight (HMW)-adiponectin levels in healthy subjects were elevated by ANP infusion [ 83 ].…”

Section: Cardiokines-mediated Physiological and Pathological Communic...mentioning

confidence: 99%

Cardiac-to-adipose axis in metabolic homeostasis and diseases: special instructions from the heart

Tang,

Li,

et al. 2023

Cell Biosci

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Adipose tissue is essential for maintaining systemic metabolic homeostasis through traditional metabolic regulation, endocrine crosstalk, and extracellular vesicle production. Adipose dysfunction is a risk factor for cardiovascular diseases. The heart is a traditional pump organ. However, it has recently been recognized to coordinate interorgan cross-talk by providing peripheral signals known as cardiokines. These molecules include specific peptides, proteins, microRNAs and novel extracellular vesicle-carried cargoes. Current studies have shown that generalized cardiokine-mediated adipose regulation affects systemic metabolism. Cardiokines regulate lipolysis, adipogenesis, energy expenditure, thermogenesis during cold exposure and adipokine production. Moreover, cardiokines participate in pathological processes such as obesity, diabetes and ischemic heart injury. The underlying mechanisms of the cardiac-to-adipose axis mediated by cardiokines will be further discussed to provide potential therapeutic targets for metabolic diseases and support a new perspective on the need to correct adipose dysfunction after ischemic heart injury.

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Obesity, Adipokines, and Lipokines

Naruse

2018

Preeclampsia

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Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte

Cited by 4 publications

References 26 publications

Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation

Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation

Cardiac-to-adipose axis in metabolic homeostasis and diseases: special instructions from the heart

Obesity, Adipokines, and Lipokines

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