Increase of Incidence and Mortality of Ovarian Cancer during 2003–2012 in Jiangsu Province, China

Abstract

PurposeThe objective of this study is to investigate and analyze the epidemiologic characteristics and time trends of ovarian cancer incidence and mortality in Jiangsu Province of China during 2003–2012.MethodData were collected from eligible cancer registries in Jiangsu Province. Crude rates, age-specific rates, truncated age-standardized rate, and proportions of ovarian cancer were calculated. The Segi’s World Population was used to calculate age-standardized rates for world (ASW). Poisson distribution was used to analyze the differences between urban and rural areas. Joinpoint regression was performed to estimate the annual percent change (APC) of ovarian cancer incidence/mortality.ResultsA total number of 4,401 new cases and 1,918 deaths were identified during period 2003–2012. The incidence and mortality ASW was 3.64/100,000 and 1.52/100,000, respectively. ASW of incidence was 4.48/100,000 in urban areas, while 3.04/100,000 in rural areas. The mortality of ASW was slight higher in urban areas than in rural areas. Age-specific incidence showed a peak at the age group of 60–64 years, whereas mortality peaked at age group of 65–69 years. A significant increase of incidence was observed from 2003 to 2006, with an APC of 34.0% (95% CI: 9.7, 63.7), the increasing rate declined since 2006 (APC = 3.3%, 95% CI: −3.5, 10.5). The mortality showed a gentle upward trend as compared with incidence, with an APC of 9.9% (95% CI: 7.7, 12.2) per year, continuously from 2003 to 2012. It is apparent that both incidence and mortality presented a rising trend in all areas, but urban were higher than that in rural areas.ConclusionOvarian cancer is a highly lethal disease which is becoming a significant public health problem in Chinese women. It is vital to improve the understanding of current status of ovarian cancer. Moreover, prevention and control policies should be formulated to reduce the disease burden of ovarian cancer in China.

The lncRNA SNHG15/miR‐18a‐5p axis promotes cell proliferation in ovarian cancer through activating Akt/mTOR signaling pathway

“…OC, a gynecologic malignancy, is the sixth most common type of cancer and a well-known silent killer in females over the world. 1 A large percentage of patients with OC are diagnosed at their advanced stages, due to the obscure symptoms of early-stage OC, as well as the lack of effective diagnostic methodologies. 18 Previous studies have shown that the development of OC is closely involved with genetic alternation.…”

“…Ovarian cancer (OC) is one of the most dangerous gynecologic malignancy and the sixth most common cancer in females over the world. 1 Researchers have paid many efforts and promoted the development in diagnostics and cytotoxic therapies. However, the 5-year survival rate of patients with advanced-stage ovarian cancer is still as low as 30%.…”

Epidemiology of ovarian cancer: a review

“…Conversely, historically less developed countries with recent economic growth and lifestyle changes have seen increases in incidence and mortality rates. In China, the increase is apparent only among rural women rather than those in more developed, urban regions 2,41 . …”

MiR-203a-3p regulates the biological behaviors of ovarian cancer cells through mediating the Akt/GSK-3β/Snail signaling pathway by targeting ATM

“…Of all primary ovarian tumors, approximately 90% are epithelial ovarian cancer, which can be classified pathologically into different types, such as serous, mucinous, endometrioid, clear-cell and transitional-cell carcinomas [2]. In recent years, nearly 70% of patients have been diagnosed with ovarian cancer when they are in the middle or advanced stage due to the lack of effective screening strategies [3], resulting in a relatively low5-year survival rate [4]. Given the above, a thorough understanding of the mechanism of ovarian cancer would be beneficial for the early diagnosis and clinical treatment of ovarian cancer.…”