Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status

Myśliwska, Jolanta; Bryl, Ewa; Foerster, Jerzy; Myśliwski, Andrzej

doi:10.1016/s0047-6374(97)00154-1

Cited by 103 publications

(61 citation statements)

References 38 publications

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“…Values could increase in women. 31 We only found variations in offspring. Metabolic pathways underlying the age-related variation in IL-6 are still under investigation.…”

Section: Discussionmentioning

confidence: 72%

Biological variations, genetic polymorphisms and familial resemblance of TNF-α and IL-6 concentrations: STANISLAS cohort

et al. 2004

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Cytokines are involved in the development of several inflammatory diseases and atherosclerosis. Their variations in healthy individuals are not well defined. The aims of this study were: firstly, to identify factors affecting biological variation of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-a); secondly, to study their family resemblance; and thirdly, to evaluate the effect of two TNF-a (À308G/A and À238G/A) and two IL-6 polymorphisms (174G/C and À572G/C) on their corresponding circulating levels. A total of 171 healthy families selected from the STANISLAS cohort were studied. Age was negatively related to TNFa concentrations in offspring only (both sons and daughters). Additionally, IL-6 and TNF-a levels were differently influenced by gender, white blood cells, tobacco consumption, and HDL-cholesterol level. A weak significant familial resemblance for TNF-a concentration was observed in siblings only. There was no significant familial resemblance for IL-6 levels. The TNF-a À308A allele was associated with decreased TNFa concentrations in both offspring aged less than 18 and males without overweight (BMIo25 kg/m 2 ). Fathers carrying the IL-6 À174CC genotype had higher IL-6 levels than those with the IL-6 À174G allele. Parents with the IL-6 À572GG genotype had higher IL-6 concentrations than the C allele carriers. In this sample of healthy families, plasma levels of IL-6 and TNF-a were differently affected by biological parameters including age, gender and smoking, and the impact of their respective polymorphisms was influenced by gender, age and BMI.

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“…Values could increase in women. 31 We only found variations in offspring. Metabolic pathways underlying the age-related variation in IL-6 are still under investigation.…”

Section: Discussionmentioning

confidence: 72%

Biological variations, genetic polymorphisms and familial resemblance of TNF-α and IL-6 concentrations: STANISLAS cohort

et al. 2004

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“…It was therefore suggested that subclinical infections may have been responsible for this even in apparently healthy elderly donors (253). Indeed, the production of factors such as IL 6 is clearly influenced by health status, even in "near-SENIEUR" donors (254). In fact, as mentioned above, it has been proposed that IL 6 levels may be a good overall biomarker of general health in aging because plasma levels are correlated with functional status (216).…”

Section: Cytokine Production and Responsementioning

confidence: 99%

T cells and aging update February 1999

Pawelec¹

1999

Front Biosci

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T cell immunosenescence 218effects of dysregulated immune responses in the elderly by supplementation or other approaches may result in an enhancement of their quality of life, and significant reductions in the cost of medical care in old age. FACTORS CONTRIBUTING TO IMMUNO-SENESCENCE HematopoiesisDysregulated hematopoiesis is seen in elderly individuals, raising the possibility that this could contribute to altered immune function in the aged. Hematopoiesis in man may be compromised because of a severely reduced capacity to produce colony stimulating factors (44) and increased production of pro-inflammatory factors such as IL 6 (45), because lower numbers of progenitor cells are present in the BM (46) and because of an age-related decline in proliferative potential of putative haematopoietic stem cells (HSC) (47). In mice, the repopulating potential of murine fetal liver-derived HSC is higher than that of adult BM-derived stem cells (48), suggesting possible aging of the HSC themselves. Normal cells with shorter telomeres possess less remaining replicative capacity than those with longer telomeres (see section 5.2). Accordingly, HSC from adult BM were found to have shorter telomeres than fetal liver-derived or umbilical cord-derived stem cells, consistent with aging of HSC (49). Telomere lengths decreased on culture despite low level expression of telomerase in these cells (50,51), although the rate of basepair loss per population doubling of cells in culture was lower during the first two weeks, when telomerase was upregulated, than in the next two, when it was downregulated (52). The telomerase expressed is therefore functionally active but may not be able to completely maintain telomere length in aging HSC cells. True embryonic stem cells (ESC), on the other hand, which may really be immortal, do retain high levels of telomerase activity (53). On the other hand, ESC from telomerase-knockout mice show gradual telomere shortening over many population doublings (PD) resulting in slowing and eventual cessation of growth (54). Certain animals which do not downregulate telomerase manifest a permanent growth phase and little or no senescence (55,56).

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“…Another study shows that high basal IL-6 had a better predictive value for mortality than TNF and that both cytokines were associated with classical risk factor like smoking, physical inactivity and body mass index (Bruunsgaard et al, 2003). A study confirmed increased serum IL-6, TGF and s-ICAM in the older people but IL-6 increased also with poor health status (comparing SENIEUR, OCTO and NONA elderly) (Forsey et al, 2003;Mysliwska et al, 1998). Serum IP-10 and CXCL9 levels have also been reported with increasing age, in contrast to IL-10 and IL-12p40.…”

Section: Toll-like Receptorsmentioning

confidence: 97%

“…With age, human and murine T cells tend to secrete less IL-2, an observation linked to important alterations in the proximal TCR signalling pathway (Boren & Gershwin, 2004;Fulop et al, 2007;Chakravarti & Abraham, 1999). Peripheral blood lymphocytes from aged individuals also display decreased NFAT expression, a key transcription factor implicated in IL-2 gene activation (Rink et al, 1998;Mysliwska et al, 1998;Wikby et al, 1994;Desai et al, 2010;DiPenta et al, 2007). However, when only "healthy older" people are considered (SENIEUR protocol), production of IL-2 was not different from that observed in younger individuals CD4 T lymphocytes from aged mice display decreased CD40L expression.…”

Section: T Lymphocytesmentioning

confidence: 99%