Increase of myocardial performance by Rhodiola–ethanol extract in diabetic rats

Cheng, Yung-Ze; Chen, Li‐Jen; Lee, Wei-Jing; Chen, Mei-Fen; Lin, Hung Jung; Cheng, Juei‐Tang

doi:10.1016/j.jep.2012.08.029

Cited by 37 publications

(37 citation statements)

References 37 publications

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“…Furthermore, activation of PPAR δ using ginseng enhanced cardiac contractility in the isolated hearts and the hemodynamic dP / dt max⁡ in the rats. Both actions of ginseng were inhibited by GSK0660 at a concentration sufficient to block PPAR δ [27, 28]. The enhancement of cardiac contractility by ginseng through an activation of PPAR δ is then characterized.…”

Section: Discussionmentioning

confidence: 99%

Ginseng Is Useful to Enhance Cardiac Contractility in Animals

Lin

Cherng

Chen

et al. 2014

BioMed Research International

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Ginseng has been shown to be effective on cardiac dysfunction. Recent evidence has highlighted the mediation of peroxisome proliferator-activated receptors (PPARs) in cardiac function. Thus, we are interested to investigate the role of PPARδ in ginseng-induced modification of cardiac contractility. The isolated hearts in Langendorff apparatus and hemodynamic analysis in catheterized rats were applied to measure the actions of ginseng ex vivo and in vivo. In normal rats, ginseng enhanced cardiac contractility and hemodynamic dP/dt max significantly. Both actions were diminished by GSK0660 at a dose enough to block PPARδ. However, ginseng failed to modify heart rate at the same dose, although it did produce a mild increase in blood pressure. Data of intracellular calcium level and Western blotting analysis showed that both the PPARδ expression and troponin I phosphorylation were raised by ginseng in neonatal rat cardiomyocyte. Thus, we suggest that ginseng could enhance cardiac contractility through increased PPARδ expression in cardiac cells.

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Section: Discussionmentioning

confidence: 99%

Ginseng Is Useful to Enhance Cardiac Contractility in Animals

Lin

Cherng

Chen

et al. 2014

BioMed Research International

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“…Rats with streptozotocin (STZ)-induced DM experienced heart failure caused by increased PPARd expression. The ethanol extract of Rhodiola increased PPARd expression and cardiac output in [84] j o u r n a l o f f o o d a n d d r u g a n a l y s i s x x x ( 2 0 1 5 ) 1 e1 1 STZ-diabetic rats [94]. Salidroside administered to mice daily (50 mg/kg, 100 mg/kg, and 200 mg/kg for 28 days) was demonstrated to cause hypoglycemic activity and have protective effects against DM-induced oxidative stress, including significantly reduced fasting blood glucose, total cholesterol, triglyceride, and MDA levels [95].…”

Section: Dmmentioning

confidence: 99%

Rhodiola plants: Chemistry and biological activity

Chiang

Chen

et al. 2015

Journal of Food and Drug Analysis

158

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Rhodiola is a genus of medicinal plants that originated in Asia and Europe and are used traditionally as adaptogens, antidepressants, and anti-inflammatory remedies. Rhodiola plants are rich in polyphenols, and salidroside and tyrosol are the primary bioactive marker compounds in the standardized extracts of Rhodiola rosea. This review article summarizes the bioactivities, including adaptogenic, antifatigue, antidepressant, antioxidant, anti-inflammatory, antinoception, and anticancer activities, and the modulation of immune function of Rhodiola plants and its two constituents, as well as their potential to prevent cardiovascular, neuronal, liver, and skin disorders.

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“…Moreover, Rhodiola has been described as antioxidant [21][22][23], anti-tumour [24,25], antidepressive [26,27], neuroprotective [28,29], cardioprotective [30,31] hepatoprotective [32,33], and immunostimulating [34][35][36]. Recently, many other benefits from the use of RR has been found including its ability to regulate blood sugar levels for diabetics and to activate the lipolytic processes [37], mobilizing lipids from adipose tissue to the natural fat burning system of body for weight reduction [8].…”

Section: Editorialmentioning

confidence: 99%

“…RR is known to induce PPARδ expression in cardiomyocytes [31]. PPARδ is an homologue of PPARγ, and it plays a role in many tissues such as brain, skin, muscles and adipocytes [44].…”

Section: Editorialmentioning

confidence: 99%

Rhodiola Rosea: From the Adaptogenic Role to the Anti-Adipogenic Effect?

Colitti¹

2014

Endocrinol Metab Syndr

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EditorialMany natural phytonutrients have beneficial effects on health [1,2]. In addition, several botanicals have received positive attention, based on their relative safety and the accumulation of evidence of their antiadipogenic and metabolic effects in animals and humans [3]. Natural products can decrease of lipid absorption, energy intake, lipogenesis, pre-adipocyte differentiation and proliferation or increase of energy expenditure, and lipolysis [4]. These properties exist in specific flavonoids [5], chlorogenic acid from green coffee bean [6], and carnosic acid in rosemary [7]. Extracts from Rhodiola rosea (RR) root is poorly characterized for its properties on adipocytes and only recently it has been proposed for a the adjuvant treatment of obesity against obesity [8].RR is a popular plant in traditional medical systems in the Nordic countries, Eastern Europe and Asia. It belongs to the family of Crassulaceae with a notoriety for stimulating physical endurance, attention span, memory, and work productivity [9][10][11]. The genus Rhodiola contains more than 100 different species, and at least 20 of these are used in traditional Asian medicine [12,13]. However, the most of all animal and human studies has been conducted on RR, so whether other species confer the same health benefits is unknown [14,15].Researches on the RR root phytochemistry has revealed the presence of six distinct groups of chemical compounds: phenylpropanoids (rosavin, rosin, rosarin), phenylethanol derivatives (salidroside, tyrosol); flavonoids (rodiolin, rodionin, rodiosin, acetylrodalgin, tricin), monoterpernes (rosiridol, rosaridin), triterpenes (daucosterol, beta-sitosterol) and phenolic acids (chlorogenic and hydroxycinnamic, gallic acids) [9,16].According to the Soviet Pharmacopeia [17,18], the extracts of RRprimarily in the form of water/alcohol tinctures or dried root extractare standardized for both rosavins and salidroside. RR extracts used in most human clinical studies were standardized to minimum 3% rosavins and 0.8-1% salidroside, because the naturally occurring ratio of these compounds in RR root is approximately 3:1 [14].The main effects of genus Rhodiola described are adaptogenic that means 'natural herbal products which are non-toxic in normal doses, produce a non-specific response, and have a normalizing physiologic influence' and stress protective [19,20]. Moreover, Rhodiola has been described as antioxidant [21][22][23] [32,33], and immunostimulating [34][35][36]. Recently, many other benefits from the use of RR has been found including its ability to regulate blood sugar levels for diabetics and to activate the lipolytic processes [37], mobilizing lipids from adipose tissue to the natural fat burning system of body for weight reduction [8]. In combination with Citrus aurantium, RR has been found to decrease visceral fat weight by 30% of rats fed with high fat diet, having a direct effect on sympathetic tone and on hypothalamic norepinephrine secretion [8]. Although detailed molecular mechanism of the lipid loweri...

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Increase of myocardial performance by Rhodiola–ethanol extract in diabetic rats

Cited by 37 publications

References 37 publications

Ginseng Is Useful to Enhance Cardiac Contractility in Animals

Ginseng Is Useful to Enhance Cardiac Contractility in Animals

Rhodiola plants: Chemistry and biological activity

Rhodiola Rosea: From the Adaptogenic Role to the Anti-Adipogenic Effect?

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