1987
DOI: 10.1159/000215574
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Increase of Nonplasmin Fibrinolytic Activity in the Lung and Spleen of Streptozotocin-Induced Diabetic Rats

Abstract: In streptozotocin-induced diabetes in rats, nonplasmin fibrinolytic activity was found to be significantly increased in the lung and spleen, but not in the liver and kidney. The plasminogen-activator activities, either soluble or insoluble, were almost simultaneously increased in the lung, suggesting the possible release of plasminogen-activator from the lung to the blood. It seems likely that plasminogen-activator of the usual type and nonplasmin protease are also involved in thrombotic disorders in the exper… Show more

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Cited by 1 publication
(2 citation statements)
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“…The first one is about the spleen fibrinolytic proteinase, which is the unique proteinase in the spleen and capable of degrading fibrin and fibrinogen at neutral pH [16] . The second one reported increased nonplasmin fibrinolytic activity in the spleen and lungs in response to increase in coagulation activity in streptozotocin-induced diabetic rats [17] . The third reported an increase in anticoagulant activity of the blood perfused through the spleen taken out of the body by splenectomy; the increase was not associated with platelet count, heparin or prothrombin [18] .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The first one is about the spleen fibrinolytic proteinase, which is the unique proteinase in the spleen and capable of degrading fibrin and fibrinogen at neutral pH [16] . The second one reported increased nonplasmin fibrinolytic activity in the spleen and lungs in response to increase in coagulation activity in streptozotocin-induced diabetic rats [17] . The third reported an increase in anticoagulant activity of the blood perfused through the spleen taken out of the body by splenectomy; the increase was not associated with platelet count, heparin or prothrombin [18] .…”
Section: Discussionmentioning
confidence: 99%
“…The burden of spleen in clearing fibrin degradation products and MPs is increased in patients experiencing several thrombotic events. In patients experiencing repetitive thrombotic events, there might be a need for the spleen to exert more anticoagulant and fibrinolytic activity [16][17][18][19] .…”
Section: Discussionmentioning
confidence: 99%