Increase of Serotonin Levels in the Specific Serotonergic Neurons of Rat Brain Caused by Phenelzine

Inhibition of Monoamine Oxidase in the Rat Brain Neurons Exerted by Isocarboxazid

“…Compared with phenelzine [1], tranylcypromine [2] and phcniprazine [3], however, i. turns out to be somewhat weaker in action under the same experimental conditions.…”

“…It has been shown recently that phenelzine [1] and tranylcy promine [2] are potent monoamine oxidase (MAO) inhibitors and responsible for the increase in 5-hydroxy try ptamine (5-IIT) in the neurons of the rat's lower brain stem. In the present study an attempt is made to investigate the action of another MAO inhibitor, isocarboxazid (i., 1-benzyl 2 (5-methyl 3-isoxazoly carbonyl) hydra zine, Marplan® at the neuronal level.…”