Increased 18F-ALF-NOTA-FAPI and 18F-FDG Uptake in Renal Angiomyolipoma

Guo, Yue-Hong; Yang, Min-Fu

doi:10.1097/rlu.0000000000004022

Cited by 10 publications

(12 citation statements)

References 9 publications

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“…Currently, fibroblast activating protein (FAP)-specific PET tracers have been reported for imaging various types of renal malignant and benign diseases. [8][9][10][11][12][13][14][15][16] In this case, renal leiomyoma showed intense 68 Ga-FAPI uptake, which may be due to the activation of pathological interstitial tissue causing increased expression of FAP. In this case, low glucose transporter but high FAP may be expressed in the renal leiomyoma; thus, this lesion demonstrated a slight 18 F-FDG but intense 68 Ga-FAPI uptake.…”

mentioning

confidence: 67%

“…18 F-FDG PET/CT imaging findings for leiomyomas of the nasal, 3 duodenal, 4 rectal, 5 uterine, 6 esophageal, and genital 7 have been reported in some previous literature, and these leiomyomas demonstrated varying degrees of 18 F-FDG uptake. Currently, fibroblast activating protein (FAP)–specific PET tracers have been reported for imaging various types of renal malignant and benign diseases 8–16 . In this case, renal leiomyoma showed intense 68 Ga-FAPI uptake, which may be due to the activation of pathological interstitial tissue causing increased expression of FAP.…”

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confidence: 87%

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Comparison of 18F-FDG and 68Ga-FAPI PET/CT in a Rare Renal Leiomyoma

Liu,

Zhang,

Lan

et al. 2023

Clin Nucl Med

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Renal leiomyoma is a rare benign mesenchymal tumor of the kidney, which mainly originates from the renal capsule or pelvis. We described 18F-FDG and 68Ga-FAPI PET/CT findings in a case of renal leiomyoma. The PET/CT findings showed that the left renal leiomyoma demonstrated intensively increased 68Ga-FAPI uptake, whereas only inhomogeneously slightly increased 18F-FDG uptake. This case illustrates that 68Ga-FAPI PET/CT may be an effective tool for detecting renal leiomyoma.

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confidence: 67%

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confidence: 87%

Comparison of 18F-FDG and 68Ga-FAPI PET/CT in a Rare Renal Leiomyoma

Liu,

Zhang,

Lan

et al. 2023

Clin Nucl Med

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“…31 Guo et al showed that angiogenesis correlated positively with 18F-FDG uptake in lung adenocarcinomas. 32 Kaira et al showed that the metabolic activity of primary tumors as evaluated by PET study with 18F-FMT and 18F-FDG was related to tumor angiogenesis and the proliferative activity in non-small cell lung cancer. 33 Studies had also shown that 18F-FDG kinetics were modulated by angiogenesis-related gene.…”

Section: Discussionmentioning

confidence: 99%

Apatinib Combined With Radiotherapy Enhances Antitumor Effects in an In Vivo Nasopharyngeal Carcinoma Model

Liu

Zhang

et al. 2020

Cancer Control

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Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are highly expressed in nasopharyngeal carcinoma; therefore, blocking the binding of VEGF and VEGFR may be a potential way to treat nasopharyngeal carcinoma. Apatinib inhibits tumor angiogenesis. Previous studies have suggested that treatment with apatinib has an antitumor effect on nasopharyngeal carcinoma. This study will investigate the effect of apatinib combined with radiotherapy. In this study, nude mice injected with CNE-2 nasopharyngeal carcinoma cells were randomly divided into 6 groups. Therapeutic effects were assessed by evaluating tumor inhibition rate, phosphorylation of VEGFR-2, CD31, partial oxygen pressure, and tumor metabolism. We found that the tumor inhibition of mice in the treated groups was better compared to that of the control group. In mice treated with apatinib alone, angiogenesis was prevented, and the tumor tissue partial oxygen pressure was reduced, thereby achieving an antitumor effect. Moreover, the tumor inhibitory effect of combined treatment was stronger than treatment with either apatinib or radiotherapy alone. Compared with monotherapy treatment, combined treatment better resisted angiogenesis. Apatinib combined with radiotherapy to treat nasopharyngeal carcinoma has synergistic effects, which may be related to enhanced antiangiogenesis.

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“…A few case reports showed intense FAPI uptake in renal angiomyolipomas of the patients without tuberous sclerosis complex. [12][13][14]…”

Section: Figurementioning

confidence: 99%

68Ga-FAPI-04 PET/MRI in a Case of Tuberous Sclerosis Complex With Extrarenal Retroperitoneal Angiomyolipoma

Dong

Yang

et al. 2023

Clin Nucl Med

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Extrarenal retroperitoneal angiomyolipomas are rare benign tumors that may mimic other benign or malignant retroperitoneal tumors. We describe 68 Ga-FAPI-04 PET/MRI findings in a case of tuberous sclerosis complex with an extrarenal retroperitoneal angiomyolipoma and multiple angiomyolipomas involving bilateral kidneys. The extrarenal retroperitoneal angiomyolipoma and most of the renal angiomyolipomas were 68 Ga-FAPI-04-avid. One left renal angiomyolipoma with extensive hemorrhage and fibrosis had no significant 68 Ga-FAPI-04 uptake. Angiomyolipoma should be included in the differential diagnosis of FAPI-avid renal or extrarenal retroperitoneal lesions.

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Increased 18F-ALF-NOTA-FAPI and 18F-FDG Uptake in Renal Angiomyolipoma

Abstract: Angiomyolipoma is a common benign tumor in the kidney. Previous publication reported that renal angiomyolipoma had very low to low uptake of 18 F-FDG. We report a case of pathologically proven angiomyolipoma in the left kidney with intense 18 F-FDG and 18 F-ALF-NOTA-FAPI uptake.

Cited by 10 publications

References 9 publications

Comparison of 18F-FDG and 68Ga-FAPI PET/CT in a Rare Renal Leiomyoma

Comparison of 18F-FDG and 68Ga-FAPI PET/CT in a Rare Renal Leiomyoma

Apatinib Combined With Radiotherapy Enhances Antitumor Effects in an In Vivo Nasopharyngeal Carcinoma Model

68Ga-FAPI-04 PET/MRI in a Case of Tuberous Sclerosis Complex With Extrarenal Retroperitoneal Angiomyolipoma

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