Increased 99mTc-Sestamibi Washout Reflects Impaired Myocardial Contractile and Relaxation Reserve During Dobutamine Stress Due to Mitochondrial Dysfunction in Dilated Cardiomyopathy Patients

Hayashi, Daisuke; Ohshima, Satoru; Isobe, Satoshi; Cheng, Xian Wu; Unno, Kazumasa; Funahashi, Hidehito; Shinoda, Norihiro; Okumura, Takahiro; Hirashiki, Akihiro; Katô, Katsuhiko; Murohara, Toyoaki

doi:10.1016/j.jacc.2013.01.074

Cited by 46 publications

(45 citation statements)

References 26 publications

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“…99m Tc-MIBI imaging is now accepted as an indicator of radiopharmaceutical accumulation in mitochondria [4][5][6][7][8][9][10][11][12] . However, there is no generally accepted standardized method for measuring mitochondrial function.…”

Section: Discussionmentioning

confidence: 99%

“…Kawamoto et al reported decreased retention of 99m Tc-MIBI in the hearts of patients with heart failure, which is associated with decreased mitochondrial membrane potential 5) . Several studies have reported that decreased retention of 99m Tc-MIBI in the heart reflects impaired myocardial con-*Correspondence: shinjisato2005hawaii@yahoo.co.jp tractility due to mitochondrial dysfunction in patients with cardiomyopathy [6][7] . Moreover, Crane et al demonstrated that mitochondrial retention of 99m Tc-MIBI was not organ specific 7) .…”

Section: Introductionmentioning

confidence: 99%

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Technetium-99m sestamibi retention in skeletal muscles, a potential indicator of mitochondrial function and anaerobic threshold in patients with type 2 diabetes

Sato

Kato

Otsuki

et al. 2015

JPFSM

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In this study, we investigated the retention of technetium-99m sestamibi (MIBI), a radiopharmaceutical that accumulates in mitochondria, in patients with type 2 diabetes. We hypothesized that patients with type 2 diabetes had lower MIBI counts in their legs than nondiabetic volunteers, and that these abnormalities reflected a low anaerobic threshold (AT) during cardiopulmonary exercise testing (CPX). Eight non-diabetic volunteers (Group N) and 11 patients with type 2 diabetes (Group D) underwent CPX. Mitochondrial function was assessed using MIBI imaging of both legs. The MIBI counts in the legs were significantly lower in Group D than in Group N (D vs. N: 74.1 vs. 94.1 counts/pixel, p < 0.05). Similarly, peak oxygen uptake (peakV ・ O 2 ) and AT were lower in Group D than in Group N (peakV ・ O 2 : 19.8 vs. 26.5 ml/kg/min, p < 0.05; AT: 13.1 vs. 17.2 ml/kg/min, p < 0.05). A strong correlation was observed between MIBI counts and the peakV ・ O 2 and AT (peakV ・ O 2 : r = 0.62, p < 0.01; AT: r = 0.76, p < 0.01). After the exclusion of an outlying subject, the correlation between peakV ・ O 2 and MIBI count in the legs was lost (r = 0.28, p = 0.26); however, the AT correlation was maintained (r = 0.59, p = 0.01). Patients with type 2 diabetes had reduced skeletal muscle MIBI counts, indicating reduced mitochondrial function. This abnormality may be linked to a low AT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Technetium-99m sestamibi retention in skeletal muscles, a potential indicator of mitochondrial function and anaerobic threshold in patients with type 2 diabetes

Sato

Kato

Otsuki

et al. 2015

JPFSM

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“…Another potential mechanism that would explain why segments that are viable by 201Tl criteria do not respond to dobutamine relates to tethering of these segments to regions of extensive scar, which would inhibit recovery of systolic function after successful revascularization. Here, viability is not "overestimated" by 201Tl scintigraphy [53]. These tethered segments are indeed viable but cannot respond to an inotropic stimulus with enhanced regional thickening or wall motion.…”

mentioning

confidence: 74%

“…Thus, revascularization may not improve resting function in this situation compared with the situation of severe resting regional asynergy without extensive scar (hibernation) [53]. Another potential mechanism that would explain why segments that are viable by 201Tl criteria do not respond to dobutamine relates to tethering of these segments to regions of extensive scar, which would inhibit recovery of systolic function after successful revascularization.…”

mentioning

confidence: 99%

Differentiation between Clinical and Academic Myocardial Viability. Complementary Myocardial Perfusion SPECT and Low Dose Dobutamine Echocardiography Role vs. Histopathological Study

Wahdan¹,

Elsaban²

2017

J Nucl Med Radiat Ther

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“…WR negatively correlated with LVEF (r 2 = 0.679). Hayashi and colleagues [27] added significant information to these observations. These investigators studied 20 patients with dilated cardiomyopathy (NYHA class I = 8, class II = 10 and class III = 2; mean LVEF = 33 %) divided into two groups on the basis of WR.…”

Section: Mitochondriamentioning

confidence: 97%

Additional applications of approved radiopharmaceuticals for nuclear cardiology

Strausś

Fox

2013

Clin Transl Imaging

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Radionuclide studies of the heart and blood vessels provide information for patient management as well as an understanding of patient-specific pathophysiology. The information gleaned from these studies may be enhanced by using more than a single tracer or by making multiple measurements with a single radiopharmaceutical (similar to measuring thallium redistribution). After more than 40 years of clinical use (Valenta et al., Curr Cardiol Rep 15:344, 2013), the examination with the most clinical value continues to be myocardial perfusion imaging for detection of myocardial ischemia and scar. New techniques, however, are available to expand the application of approved radiopharmaceuticals in patients with heart disease. This manuscript will present recent developments in two areas: (1) Evaluation of mitochondrial function or sympathetic innervation in patients with heart failure (HF). In this case, radionuclide techniques provide data that adds significant predictive value to functional parameters, such as left ventricular ejection fraction, to identify HF patients at high risk of clinical events. (2) Direct evaluation of focal vascular inflammation, microcalcification and calcification in patients with dyslipidemia. Localization and characterization of the intensity of inflammation, or early phases of calcification in atheroma, may permit more personalized therapy than can be obtained from traditional measurements of lipid levels in patients with dyslipidemia. Ultimately, characterizing atheroma, especially in the coronary and carotid arteries, may be the imaging approach of choice to permit effective pharmacologic therapy geared at reducing the incidence and severity of clinical events.

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Increased 99mTc-Sestamibi Washout Reflects Impaired Myocardial Contractile and Relaxation Reserve During Dobutamine Stress Due to Mitochondrial Dysfunction in Dilated Cardiomyopathy Patients

Abstract: Increased (99m)Tc-MIBI washout may predict mitochondrial dysfunction and the impairment of myocardial contractile and relaxation reserves during dobutamine stress in DCM patients.

Cited by 46 publications

References 26 publications

Technetium-99m sestamibi retention in skeletal muscles, a potential indicator of mitochondrial function and anaerobic threshold in patients with type 2 diabetes

Technetium-99m sestamibi retention in skeletal muscles, a potential indicator of mitochondrial function and anaerobic threshold in patients with type 2 diabetes

Differentiation between Clinical and Academic Myocardial Viability. Complementary Myocardial Perfusion SPECT and Low Dose Dobutamine Echocardiography Role vs. Histopathological Study

Additional applications of approved radiopharmaceuticals for nuclear cardiology

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