Increased Accumulation of Regulatory Granulocytic Myeloid Cells in Mannose Receptor C Type 1-Deficient Mice Correlates with Protection in a Mouse Model of Neurocysticercosis

Mishra, Pramod Kumar; Morris, Elizabeth G.; Garcia, Jenny A.; Cardona, Astrid E.; Teale, Judy M.

doi:10.1128/iai.01176-12

Cited by 11 publications

(15 citation statements)

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“…An analysis of MDSCs subsets in the liver and spleen revealed that the number of G-MDSCs was higher in infected BALB/c with respect to B6 mice, suggesting a protective role for G-MDSCs in the resolution of inflammation. In agreement with this concept, an increased accumulation of G-MDSCs has been correlated with reduced tissue injury in various experimental models of inflammation [30][31][32]. In cancer, the frequency of each MDSCs subset appears to be influenced by the type of tumor [2].…”

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confidence: 57%

Myeloid‐derived suppressor cells are key players in the resolution of inflammation during a model of acute infection

et al. 2013

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Myeloid-derived suppressor cells (MDSCs Keywords: Inflammation r MDSCs r Nitric oxide r ROS r Trypanosoma cruziAdditional supporting information may be found in the online version of this article at the publisher's web-site IntroductionMyeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population consisting of immature macrophages, granulocytes, and dendritic cells as well as myeloid progenitor cells. They are considered to be one of the major components of the immune suppressive network responsible for suppressing T-cell responses in pathological conditions [1,2] as well as in the regulation of the immune response in healthy individuals [3]. These Correspondence: Dr. Susana Gea e-mail: sgea@fcq.unc.edu.ar myeloid cells are commonly identified in mice by the co-expression of the surface markers CD11b and Gr1 (Ly6G/Ly6C) and have been divided into two subsets: granulocytic (G) MDSCs with a CD11b + LY6G + LY6C low phenotype and monocytic (M) MDSCs with CD11b + LY6G − LY6C high phenotype [3,4]. Despite their morphological similarities, G-MDSCs and neutrophils are functionally and phenotypically different. G-MDSCs, but not neutrophils, are immunosuppressive and express higher levels of arginase-1 and myeloperoxidase than neutrophils, and also have increased production of reactive oxygen species (ROS) [5,6]. Although * These authors contributed equally to this work.www.eji-journal.eu Eur. J. Immunol. 2014. 44: 184-194 Immunomodulation 185 M-MDSCs and inflammatory monocytes share the same phenotype and morphology, these cells are functionally distinct since M-MDSCs are highly immunosuppressive and they express high levels of both iNOS and arginase-1. Furthermore, although iNOS expression is a hallmark of a tumoricidal/microbicidal phenotype in M1 macrophages, iNOS promotes suppressive activities in M-MDSCs. This shift in iNOS activity most likely reflects the crosstalk of iNOS with other enzymes such as NADPH oxidase to promote the production of peroxynitrites, which inhibits the proliferation and effector function of T cells [2]. MDSCs use several mechanisms in addition to the production of ROS and NO, such as triggering apoptosis of activated T cells by depleting of L-arginine, via arginase [7][8][9][10]. There is also evidence that MDSCs may suppress immune activation by inducing T regulatory cell expansion [11]. Other suppressive mechanisms that have recently been proposed include the production of TGF-β [12,13], depletion of cysteine [8], induction of COX2 and prostaglandin E2 [1,[14][15][16].Trypanosoma cruzi an obligate intracellular protozoan, is the causative agent of Chagas disease. This disease affects about 20 million people in Latin America, with 120 million persons at risk. In the past decades, mainly as a result of increased migrations, the diagnosed cases have also increased in nonendemic countries such as Canada, United States of America, and Europe. This has led to an increased risk of transmission of the infection, mainly through blood transfusion and organ transplantation [17]. Pa...

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Myeloid‐derived suppressor cells are key players in the resolution of inflammation during a model of acute infection

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“…Helicobacter pylori Lactobacillus spp. Gringhuis et al, 2007;Konstantinov et al, 2008;Geijtenbeek and Gringhuis, 2009;Mesman et al, 2012;Avota et al, 2013;Chen et al, 2013;Harman et al, 2013;Hillaire et al, 2013 SIGNR3 High mannose and fucose L. infantum SEA Powlesland et al, 2006;Meevissen et al, 2012;Lefevre et al, 2013;Prasanphanich et al, 2013 SIGNR1 High mannose and fucose SEA Galustian et al, 2004;Meevissen et al, 2012;Prasanphanich et al Kang et al, 2005;Deschoolmeester et al, 2009;Geijtenbeek and Gringhuis, 2009;Everts et al, 2012;Meevissen et al, 2012;Mishra et al, 2013;Prasanphanich et al, 2013;Salazar et al, 2013 DEC-205 (CD205) PLA Y. pestis Zhang et al, 2008 Relevant references are indicated in text. HDM, house dust mite; HIV, human immunodeficiency virus; JEV, Japanese encephalitis virus ManLam, mannosylated lipoarabinomannan; PLA, plasminogen activator; SEA, schistosoma egg antigen; SlpA, surface layer A protein; TDM, trehalose-6,6′-dimycolate.…”

Section: C-type Lectin Receptors: General Overviewmentioning

confidence: 99%

Signalling C ‐Type lectin receptors, microbial recognition and immunity

2014

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Signalling C-type lectin receptors (CLRs) are crucial in shaping the immune response to fungal pathogens, but comparably little is known about the role of these receptors in bacterial, viral and parasitic infections. CLRs have many diverse functions depending on the signalling motifs in their cytoplasmic domains, and can induce endocytic, phagocytic, antimicrobial, pro-inflammatory or anti-inflammatory responses which are either protective or not during an infection. Understanding the role of CLRs in shaping anti-microbial immunity offers great potential for the future development of therapeutics for disease intervention. In this review we will focus on the recognition of bacterial, viral and parasitic pathogens by CLRs, and how these receptors influence the outcome of infection. We will also provide a brief update on the role of CLRs in antifungal immunity.

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“…MDSCs accumulate in large numbers during many pathological conditions such as cancer, infectious diseases, trauma, autoimmune diseases, and transplantation. [2][3][4][5] Our review will elucidate the molecular pathways responsible for the induction and function of MDSCs.…”

Section: Introductionmentioning

confidence: 99%

Phenotype, development, and biological function of myeloid-derived suppressor cells

et al. 2015

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Increased Accumulation of Regulatory Granulocytic Myeloid Cells in Mannose Receptor C Type 1-Deficient Mice Correlates with Protection in a Mouse Model of Neurocysticercosis

Cited by 11 publications

References 71 publications

Myeloid‐derived suppressor cells are key players in the resolution of inflammation during a model of acute infection

Myeloid‐derived suppressor cells are key players in the resolution of inflammation during a model of acute infection

Signalling C ‐Type lectin receptors, microbial recognition and immunity

Phenotype, development, and biological function of myeloid-derived suppressor cells

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