Increased ACE in extrahepatic cholangiocarcinoma as a clue for activated RAS in biliary neoplasms

Beyazıt, Yavuz; Pürnak, Tuğrul; Suvak, Burak; Kurt, Mevlüt; Sayılır, Abdurrahim; Turhan, Turan; Taş, Adnan; Torun, Serkan; Çelik, Tuğrul; İbi̇ş, Mehmet; Haznedaroğlu, İbrahim C.

doi:10.1016/j.clinre.2011.06.008

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…It plays a key role in the RAS mainly via two seven transmembrane domain receptors termed AT1R and Ang-II type 2 receptor (AT2R), showing a complicated pattern of regulation and function [11,20]. The majority of Ang-II effects are mediated by AT1R.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to these physiologic effects, recent trials have proposed the concept of a local tissue RAS in a variety of organ systems and its activation under tumoural conditions [10,11]. In tumor-related RAS, angiotensin II (Ang-II) is abundantly generated from angiotensin I (Ang-I) by angiotensin-converting enzyme (ACE), and type 1 angiotensin II receptor expression (AT1R) is generally upregulated [10].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

Beyazıt

Ayhan

Çelik

et al. 2015

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

Beyazıt

Ayhan

Çelik

et al. 2015

Arch Gynecol Obstet

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“…Renin levels are elevated in patients with liver cirrhosis and HCC and have been positively correlated with α-fetoprotein 54. The overexpression of ACE has been reported in extra-hepatic cholangio-carcinoma,55 leukemic myeloid blast cells,56 and macrophages in the lymph nodes of Hodgkin’s disease patients 57. AT II receptors were also shown to be expressed in all human gastric cancer lines,58 premalignant and malignant prostate cells,59 human lung cancer xenografts,60 and ovarian cancer 61.…”

Section: Genetic Factors That Relate To β-Adrenergic Inhibition and Cmentioning

confidence: 95%

The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms

Lương

Nguyễn²

2012

CMAR

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Cancer is the leading cause of death in the USA, and the incidence of cancer increases dramatically with age. Beta-adrenergic blockers appear to have a beneficial clinical effect in cancer patients. In this paper, we review the evidence of an association between β-adrenergic blockade and cancer. Genetic studies have provided the opportunity to determine which proteins link β-adrenergic blockade to cancer pathology. In particular, this link involves the major histocompatibility complex class II molecules, the renin–angiotensin system, transcription factor nuclear factor-kappa-light-chain-enhancer of activated B cells, poly(ADP-ribose) polymerase-1, vascular endothelial growth factor, and the reduced form of nicotinamide adenine dinucleotide phosphate oxidase. Beta-adrenergic blockers also exert anticancer effects through non-genomic factors, including matrix metalloproteinase, mitogen-activated protein kinase pathways, prostaglandins, cyclooxygenase-2, oxidative stress, and nitric oxide synthase. In conclusion, β-adrenergic blockade may play a beneficial role in cancer treatment. Additional investigations that examine β-adrenergic blockers as cancer therapeutics are required to further elucidate this role.

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“…Moreover, the patient with CCA was found to high ACE level. That is why it will be vital to understand the interaction of CCA and RAS in developing new strategies for cancer therapy to improve the patient's life and life quality as well [40].…”

Section: The Local Renin-angiotensin System In Liver and Cholangiocarmentioning

confidence: 99%

Local Renin-Angiotensin System at Liver and Crosstalk with Hepatic Diseases

Taşkın¹,

Güven²

2017

Renin-Angiotensin System - Past, Present and Future

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The systemic renin-angiotensin system mainly regulates blood pressure and maintains kidney function. Recent studies have realized that renin-angiotensin system (RAS) has been found in many tissues, such as heart, liver, and kidney. Although RAS in heart and kidney has been well documented, the RAS in the liver has been evaluated in a few studies. Therefore, this chapter will be assessed it. Based on findings, RAS in the liver has presented almost all of its components, such as angiotensin-I (Ang-I), angiotensin-II (Ang-II), angiotensin-converting enzyme (ACE), angiotensin type-1 receptor (AT1), angiotensin type-2 receptor (AT2), named as classical RAS. Expect these components, the local RAS has had alternative pathway components, including angiotensin-converting enzyme 2 (ACE2) and chymase. Classical RAS has an opposite effect of alternative RAS.Although these local RAS might not be such a crucial for the tissue, it could be a more vital function under pathophysiologic conditions. The chapter the local RAS in the liver the under both physiologic and pathophysiologic conditions is highlighted.

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Increased ACE in extrahepatic cholangiocarcinoma as a clue for activated RAS in biliary neoplasms

Cited by 18 publications

References 25 publications

Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms

Local Renin-Angiotensin System at Liver and Crosstalk with Hepatic Diseases

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