Increased activation in Broca's area after cognitive remediation in schizophrenia

Vianin, Pascal; Urben, Sébastien; Magistretti, Pierre J.; Marquet, Pierre; Fornari, Eleonora; Jaugey, Laure

doi:10.1016/j.pscychresns.2014.01.004

Cited by 43 publications

(39 citation statements)

References 18 publications

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“…Seventeen studies assessed changes in functional brain activity related to APM (33, 43-58), 5 studies measured the effects of rTMS (59-63), 10 studies evaluated the effects of CRT (42, 64-72), two studies measured functional brain changes following CBTp (73, 74), and two studies measured functional brain changes following tDCS (41, 75). To our knowledge, there are no studies examining the effects of avatar therapy on brain function using fMRI.…”

Section: Resultsmentioning

confidence: 99%

“…The CRT group showed an activation increase in L IFG, R IPL, R precentral gyrus, L middle occipital cortex, L middle cingulate cortex and L SPL after treatment. The CRT group also showed a better post treatment performance in the Color-Word Stroop Test and in the Matrix Reasoning Test (72). …”

Section: Resultsmentioning

confidence: 99%

“…The remaining studies reported activity increases in frontal areas. Five studies reported activity increase in IFG (64-66, 68, 72), 3 studies reported in PFC (67, 70, 71) and 3 reported changes in cingulate gyrus (65, 67, 72). Other frontal regions, which showed activity increase, were: MFG (65, 66), precentral gyrus (69, 72), DLPFC and frontopolar cortex (67), VLPFC (65) and SMA (72).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Kani

Shinn

Lewandowski

et al. 2017

Journal of Psychiatric Research

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Objectives A variety of treatment options exist for schizophrenia, but the effects of these treatments on brain function are not clearly understood. To facilitate the development of more effective treatment strategies, it is important to identify how brain function in schizophrenia patients is affected by the diverse therapeutic approaches that are currently available. The aim of the present article is to systematically review the evidence for functional brain changes associated with different treatment modalities for schizophrenia. Methods We searched PubMed for longitudinal functional MRI (fMRI) studies reporting on the effects of antipsychotic medications (APM), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), cognitive remediation therapy (CRT) and cognitive behavioral therapy for psychosis (CBTp) on brain function in schizophrenia. Results Thirty six studies fulfilled the inclusion criteria. Functional alterations were observed in diverse brain regions. Across intervention modalities, changes in fMRI parameters were reported most commonly in frontal brain regions including prefrontal cortex, anterior cingulate and inferior frontal cortex. Conclusions We conclude that current treatments for schizophrenia commonly induce functional brain alterations in frontal brain regions. However, interpretability is limited by inconsistency in task and region of interest selection, and failures to replicate. Further task independent fMRI studies examining treatment effects with whole brain analysis are needed to deepen our insights.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Kani

Shinn

Lewandowski

et al. 2017

Journal of Psychiatric Research

View full text Add to dashboard Cite

show abstract

“…Vianin et al (64) provided patients with 14 weeks of CRT training or treatment as usual and measured neural changes using a verbal fluency task during fMRI. For the CRT patients, the authors reported increased activation in the inferior parietal lobule, precentral gyrus, inferior frontal gyrus (Broca’s area), middle occipital cortex, middle cingulate cortex, and superior parietal lobule, compared to the control group after treatment.…”

Section: Resultsmentioning

confidence: 99%

Neurobiology of Cognitive Remediation Therapy for Schizophrenia: A Systematic Review

2014

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Cognitive impairment is an important aspect of schizophrenia, where cognitive remediation therapy (CRT) is a promising treatment for improving cognitive functioning. While neurobiological dysfunction in schizophrenia has been the target of much research, the neural substrate of cognitive remediation and recovery has not been thoroughly examined. The aim of the present article is to systematically review the evidence for neural changes after CRT for schizophrenia. The reviewed studies indicate that CRT affects several brain regions and circuits, including prefrontal, parietal, and limbic areas, both in terms of activity and structure. Changes in prefrontal areas are the most reported finding, fitting to previous evidence of dysfunction in this region. Two limitations of the current research are the few studies and the lack of knowledge on the mechanisms underlying neural and cognitive changes after treatment. Despite these limitations, the current evidence suggests that CRT is associated with both neurobiological and cognitive improvement. The evidence from these findings may shed light on both the neural substrate of cognitive impairment in schizophrenia, and how better treatment can be developed and applied.

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“…Computerized cognitive training could restore brain activity in the medial prefrontal cortex in a reality monitoring task and improve social functioning of schizophrenia patients (Subramaniam et al, 2012). In another study, brain activations were increased in the right precentral gyrus and the angular gyrus when performing a verbal fluency task after 14 weeks of executive function training (Vianin et al, 2014). On the other hand, the striatum also showed activation changes with WM training.…”

Section: Implications For Schizophrenia Rehabilitationmentioning

confidence: 97%

The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation

Xiao

Zhao

et al. 2015

Neuropsychologia

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Increased activation in Broca's area after cognitive remediation in schizophrenia

Cited by 43 publications

References 18 publications

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Neurobiology of Cognitive Remediation Therapy for Schizophrenia: A Systematic Review

The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation

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