Increased activity of a new chlorofluoroquinolone, BAY y 3118, compared with activities of ciprofloxacin, sparfloxacin, and other antimicrobial agents against anaerobic bacteria

Aldridge, Kenneth E.

doi:10.1128/aac.38.7.1671

Cited by 9 publications

(1 citation statement)

References 10 publications

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“…Fluoroquinolones have not been recommended for therapy of mixed aerobic-anaerobic infections because of the relatively poor activity of these agents against anaerobes. Newer fluoroquinolones, such as Bay Y3118 and WIN 57273, have increased antianaerobic activity but have not been developed due to toxicity (1,6). The present report details the in vitro activity of trovafloxacin, a new trifluoronaphthyridone agent, against clinical isolates of the Bacteroides fragilis group and other anaerobes compared to those of ciprofloxacin and other antimicrobial agents.…”

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confidence: 98%

Comparative in vitro activities of trovafloxacin (CP 99,219) and other antimicrobials against clinically significant anaerobes

Aldridge

Ashcraft

Bowman

1997

Antimicrob Agents Chemother

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A total of 590 strains of clinically important anaerobes were tested to determine their susceptibility to trovafloxacin. Overall, trovafloxacin had a mode MIC of 0.25 micrograms/ml and a MIC at which 90% of the isolates were inhibited of 1 micrograms/ml and had activity comparable to that of metronidazole. Trovafloxacin was 8-, 8-, 16-, 32-, and 64-fold more active than ampicillin-sulbactam, clindamycin, ciprofloxacin, cefoxitin, and cefotetan, respectively. Of the Bacteroides fragilis group, 97% of the isolates were inhibited by trovafloxacin at 21 micrograms/ml, and trovafloxacin was more active than ciprofloxacin, cefoxitin, cefotetan, ampicillin-sulbactam, and clindamycin against Clostridium, Fusobacterium, Porphyromonas, and Prevotella strains.

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confidence: 98%

Comparative in vitro activities of trovafloxacin (CP 99,219) and other antimicrobials against clinically significant anaerobes

Aldridge

Ashcraft

Bowman

1997

Antimicrob Agents Chemother

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Pseudoflavonifractor

Alauzet

Cailliez‐Grimal

Lozniewski

2023

Bergey's Manual of Systematics of Archaea and Bacteria

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Pseu.do.fla.vo.ni.frac'tor. Gr. adj. pseudês , false; N.L. masc. n. Flavonifractor , a bacterial genus name; N.L. masc. n. Pseudoflavonifractor , a false Flavonifractor. Firmicutes / Clostridia / Clostridiales / Oscillospiraceae / Pseudoflavonifractor Pseudoflavonifractor is a genus in the phylum Firmicutes , class Clostridia , order Clostridiales , family Oscillospiraceae . It currently comprises three species with validly published names. Pseudoflavonifractor capillosus , was proposed in 2010 to reclassify Bacteroides capillosus based on its phylogenetic position, biochemical properties, and DNA G + C content. Two other species, Pseudoflavonifractor gallinarum and Pseudoflavonifractor hominis , were described in 2021. Although phylogenetically linked to typical Gram‐positive bacteria, members of this genus stain Gram‐negative. Cells are strictly anaerobic, nonmotile, and non‐spore‐forming rods, occasionally ovoid ( P. hominis ). Optimal growth is described after at least 48 h of anaerobic incubation in nutrient‐rich broth or on sheep/horse blood agar. Colonies are minute, circular, colorless, smooth, and translucent. Members of the genus Pseudoflavonifractor are asaccharolytic although able to weakly ferment some sugars. They produce acetic and succinic acids when grown in TGY (trypticase/glucose/yeast extract) broth. The dominant fatty acids are C 14:0 and C 16:0 dimethyl acetal (DMA). They are described as members of the human and animal gut microbiota. P. capillosus has also been recovered from clinical samples as an opportunistic pathogen. DNA G + C content (mol%) : 49.22–60 ( T m and HPLC). Type species : Pseudoflavonifractor capillosus Carlier et al. 2010 VP (basonym: Bacteroides capillosus (Tissier 1908) Kelly 1957 AL ).

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Resistance mechanism ofAcinetobacter spp. strains resistant to DW-116, a new quinolone

et al. 1998

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DW-116 is a new fluoroquinolone antimicrobial agent with a broad spectrum. In order to elucidate the resistance mechanism to DW-116 in Acinetobacter spp. bacteria, total chromosomal DNA was isolated from 10 strains of Acinetobacter spp. resistant to DW-116. Quinolone resistance determinant region (QRDR) of DNA gyrase gene was amplified by PCR. The 345 bp nucleotide fragment yielded was inserted into pKF 3 which was used as the vector. Comparisons of the DNA sequences of 8 strains with that of the wild type strain revealed a Ser-83 to Leu mutation in mutants and all ten strains contained one silent mutation(T-->G) in QRDR. From Acinetobacter MB4-8 strain, DNA gyrase was isolated and purified, through no-vobiocin-sepharose, heparin-sepharose affinity column chromatography. The enzyme was composed of two subunits and the molecular mass of subunits A and B were 75.6 and 51.9 kDa, respectively. The supercoiling activity of the reconstituted DNA gyrase composed of subunit A from Acinetobacter MB4-8 and subunit B from E. coli was not inhibited by 128 micrograms/ml of ciprofloxacin. It might be said that one of the resistance mechanisms to DW-116 in A-cinetobacter MB4-8 was subunit A alteration of DNA gyrase.

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Increased activity of a new chlorofluoroquinolone, BAY y 3118, compared with activities of ciprofloxacin, sparfloxacin, and other antimicrobial agents against anaerobic bacteria

Cited by 9 publications

References 10 publications

Comparative in vitro activities of trovafloxacin (CP 99,219) and other antimicrobials against clinically significant anaerobes

Comparative in vitro activities of trovafloxacin (CP 99,219) and other antimicrobials against clinically significant anaerobes

Pseudoflavonifractor

Resistance mechanism ofAcinetobacter spp. strains resistant to DW-116, a new quinolone

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