Increased adhesiveness of white blood cells in patients with unstable angina: Additional evidence for an involvement of the immune‐inflammatory system

Abstract

SummaryBackground: Data are being accumulated on the presence of inflammatory response in patients with acute coronary syndromes.Hypothesis: The study was undertaken to confirm that the adhesive state ofthe peripheral blood leukocytes can provide information on an inflammatory process in patients with unstable angina pectoris.Methods: The study included 21 patients with unstable angina, 32 patients with stable angina, and 13 patients with chest pain and no evidence of coronary artery disease.Results: The percentage of aggregated leukocytes in patients with unstable angina (5.8 2 3.2%) was significantly (~~0 . 0 2 ) increased compared with that of patients with no evidence of active coronary disease (3.2 f 2.6%).Conclusion: Additional evidence for an existing smoldering inflammatory process in unstable angina pectoris can be provided by testing the percentage of aggregated leukocytes in peripheral blood.

Role of Infectious and Immune Factors in Coronary and Cerebrovascular Arteriosclerosis

“…9,2002 MINIREVIEWS 209 the development of coronary heart disease, did not find an association between leukocyte count and development of coronary heart disease (18). The percentage of aggregated leukocytes in patients with unstable angina is significantly increased compared to that of patients with no evidence of active coronary artery disease (54). This aggregation may be mediated by cellular adhesion molecules (CAMs).…”

COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation

“…Lastly, coronary artery disease (CAD) pathogenesis also has an established immunological component [31]. Higher levels of C-reactive protein (CRP) [32], leukocytes [33], and cytokines [34] are associated with both CAD and severe COVID-19 patients [35][36][37]. Moreover, excessive pro-inflammatory cytokine production is associated with vascular damage that induces uncontrolled blood clotting [38].…”