Increased airway smooth muscle cells in asthma: mechanisms and therapeutic prospects

Beaufils, F; Berger, Patrick

doi:10.21037/atm-22-3973

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…The thickening of the smooth muscle layer in the airway wall is among the most significant characteristics of bronchial remodeling. Moreover, numerous studies have linked increased smooth muscle mass to asthma severity in both adults and children [ 98 ]. Consequently, novel asthma treatments such as bronchial thermoplasty aim to target the smooth muscle cells of the airway.…”

Section: Epithelial Influence On Airway Smooth Muscle Cellsmentioning

confidence: 99%

Bronchial epithelial and airway smooth muscle cell interactions in health and disease

Abohalaka

2023

Heliyon

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Section: Epithelial Influence On Airway Smooth Muscle Cellsmentioning

confidence: 99%

Bronchial epithelial and airway smooth muscle cell interactions in health and disease

Abohalaka

2023

Heliyon

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“…Increased smooth muscle layer thickness in the airway wall is one of the most critical features of bronchial remodeling. In addition, many studies associated asthma severity in adults and children with increased smooth muscle mass (41). Hence, innovative asthma therapies such as bronchial thermoplasty target the airway's smooth muscle cells.…”

Section: The Effects Of Epithelium On Airway Smooth Muscle Cell Proli...mentioning

confidence: 99%

Crosstalk of Airway Smooth Muscle and Epithelial Cells in Chronic Lung Diseases

Abohalaka¹

2022

Preprint

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Chronic pulmonary diseases such as asthma, COPD, and Idiopathic pulmonary fibrosis are significant causes of mortality and morbidity worldwide. Currently, there is no radical treatment for many chronic pulmonary diseases, and the treatment options focus on relieving the symptoms and improving lung function. Therefore, efficient therapeutic agents are highly needed. Bronchial epithelial cells and airway smooth muscle cells and their crosstalk play a significant role in the pathogenesis of these diseases. Thus, targeting the interactions of these two cell types could open the door to a new generation of effective therapeutic options. However, the studies on how these two cell types interact and how their crosstalk adds up to respiratory diseases are not well established. With the rise of modern research tools and technology, such as lab-on-chip, organoids, co-culture techniques, and advanced immunofluorescence imaging, a substantial degree of evidence about these cell interactions emerged. Hence, this contribution aims to review the growing evidence of bronchial epithelial cells and airway smooth muscle cells crosstalk under normal and pathophysiological conditions. The review first deliberates the effects of both healthy and stressed epithelial cells on airway smooth muscle cells, taking into account three themes; contraction, migration, and proliferation. Then, it discusses the impact of airway smooth muscle cells on the epithelium in inflammatory settings. Later, it examines the role of airway smooth muscle cells in the early development of bronchial epithelial cells and their recovery after injury.

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Airway epithelial cells promote in vitro airway smooth muscle cell proliferation by activating the Wnt/β-catenin pathway

Liu,

Li,

Chen

et al. 2025

Respiratory Physiology & Neurobiology

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Increased airway smooth muscle cells in asthma: mechanisms and therapeutic prospects

Cited by 4 publications

References 26 publications

Bronchial epithelial and airway smooth muscle cell interactions in health and disease

Bronchial epithelial and airway smooth muscle cell interactions in health and disease

Crosstalk of Airway Smooth Muscle and Epithelial Cells in Chronic Lung Diseases

Airway epithelial cells promote in vitro airway smooth muscle cell proliferation by activating the Wnt/β-catenin pathway

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